YaJie Cui^*†, Kai’e She^‡, Defu Tian^§, Peilian Zhang^†, Xiaoyan Xin^*

Oncology Research, Vol.23, No.6, pp. 275-282, 2015, DOI:10.3727/096504016X14562725373798

Abstract Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, accounting for 90% of all ovarian cancer. Dysregulation of miRNAs is associated with several types of EOC. In the current research, we aimed to study the role of abnormal expression of miR-146a in the development of EOC and to elucidate the possible molecular mechanisms. Compared with control samples, mRNA expression of miR-146a was significantly decreased in EOC tissues and cell lines. Overexpression of miR-146a prohibited cell proliferation, enhanced apoptosis, and increased sensitivity to chemotherapy drugs in EOC cells. In contrast, downregulation of miR-146a promoted cell… More >

Meng Lu¹, Yi Miao¹, Lan Qi, Mingzhu Bai, Jiarong Zhang, Youji Feng

Oncology Research, Vol.23, No.6, pp. 267-274, 2015, DOI:10.3727/096504016X14549667333963

Abstract FKBP14 belongs to the family of FK506-binding proteins (FKBPs). Altered expression of FKBPs has been reported in several malignancies. This study aimed to reveal the expression profile of FKBP14 in ovarian cancer and evaluate whether FKBP14 is a molecular target for cancer therapy. We found that the FKBP14 mRNA level was significantly higher in ovarian cancer tissues than in normal tissues. FKBP14 expression was then knocked down in two ovarian cancer cell lines, SKOV3 and HO8910 cells, by a lentiviral short hairpin RNA (shRNA) delivery system. Reduced expression of FKBP14 markedly impaired the proliferative ability More >

Emmanuel Maurice Arthur^*, Timothy Ayando, Yakubu Ibrahim Seini

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-10, 2015, DOI:10.5098/hmt.6.21

Abstract The combined effects of chemical reaction and viscous dissipation on hydromagnetic mixed convective flow towards a vertical plate embedded in a highly porous medium with radiation and internal heat generation has been examined. The governing boundary layer equations have been transformed to a two-point boundary value problem using a local similarity approach and solved numerically using the Newton Raphson shooting method alongside the Fourth-order Runge - Kutta algorithm. The effects of various embedded parameters on fluid velocity, temperature and concentration have been presented graphically whilst the skin friction coefficient and the rates of heat and More >

Benjamin Lepers^a,∗, Thomas Seitz^a, Guido Link^a, John Jelonnek^a,b, Mark Zink^c

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-6, 2015, DOI:10.5098/hmt.6.20

Abstract A compact 10 kW microwave applicator operating at 2.45 GHz for fast volumetric heating and thermal cracking of lignite briquettes has been successfully designed and tested. In this paper, the applicator design and construction are presented together with a sequentially coupled electromagnetic, thermal-fluid and mechanical Comsol model. In a first step, this model allows us to calculate the power density inside the lignite material and the temperature distribution in the applicator for different water flow rates. In a second step, the total stress due to the thermal dilatation, the internal pressure inside the ceramic and More >

D. Srinivasacharya^a,*, A.J. Chamkha^b, O. Surender^a, A.M. Rashad^c,d

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-7, 2015, DOI:10.5098/hmt.6.19

Abstract The aim of the present article is to analyze the influence of thermal and mass stratification on natural convection heat and mass transfer over a porous vertical plate with uniform and constant wall temperature and concentration in porous medium. The Brinkman-Forchheimer based model is employed to describe the flow in the porous medium. The nonlinear governing equations and their associated boundary conditions are initially cast into dimensionless forms by pseudo-similarity variables. The resulting system of nonlinear, coupled partial differential equations is then solved numerically. The influence of pertinent parameters on the dimensionless velocity, temperature, concentration, More >

Yaqing Liu^a,*, Jinyu Ma^b

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-5, 2015, DOI:10.5098/hmt.6.17

Abstract This paper presents an exact solution for the magnetohydrodynamic (MHD) flow of an incompressible generalized Oldroyd-B fluid due to an infinite accelerating plate. The fractional calculus approach is introduced to establish the constitutive relationship of the Oldroyd-B fluid. The solutions in terms of Fox H-function are obtained by using the Laplace transform. When N = 0 the solutions corresponds to the generalized Oldroyd-B fluids, while θ → 0 and λ → 0 describes the Maxwell fluid and the generalized second fluid, as limiting cases of our general results, respectively. More >

Zhuohuan Hu^a,*, Lulu Wang^a, Hui Wang^b, Mo Yang^a

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-8, 2015, DOI:10.5098/hmt.6.16

Abstract A numerical investigation was conducted to study the heat transfer in an aircraft cabin and the effects of air distribution under different angle and inlet velocity conditions. The Reynolds-averaged Navier–Stokes equations and the low Reynolds number turbulence model were used to simulate the airflow in the cabin. Mathematical statistics was used to process the relevant data, and statistical results revealed that different inlet angles and velocities significantly affect air temperature and flow field. The study also determined a set of optimum matching inlet vane angles and inlet velocities that result in an environment which meets More >

Withada Jedsadaratanachai^a, Amnart Boonloi^b,*

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-19, 2015, DOI:10.5098/hmt.6.13

Abstract Numerical investigations on flow topology, heat transfer behavior and thermal performance evaluation in a circular tube heat exchanger with the punched delta winglet vortex generators (PDWVG) inserted in the middle of the test section are presented. The effects of the flow attack angles that converging to the center of the tube; α = 0°, 5°, 10°, 15°, 20°, 25°, and flow directions; winglet tips pointing downstream and upstream, are investigated for the Reynolds numbers; Re = 100 – 2000. The finite volume method and SIMPLE algorithm are used for the current study. The results are presented… More >

Biswajit De^*, Rajsekhar Panua

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-6, 2015, DOI:10.5098/hmt.6.11

Abstract An incorporated arithmetical model has been urbanized and investigated for CFD replication of a solitary cylinder, four stroke, straight inoculation, compressed ignition diesel engine of 3.5 kW for in-cylinder combustion analysis and authenticated under engine simulations at full load functioning conditions with foundation fuel diesel and 10% JME (volume basis) blend with diesel at invariable speed of 1500 rpm. For advancing the exactness of the exertion, a number of sub models, such as species transport model explaining the actual biodiesel energy content and molecular structure as soon as fuel blend is initiated, spray break-up model, More >

Junjie Chen^*, Xuhui Gao, Deguang Xu

Frontiers in Heat and Mass Transfer, Vol.6, pp. 1-13, 2015, DOI:10.5098/hmt.6.10

Abstract Effect of wall thermal conductivity on hydrogen self-ignition and hydrogen-assisted ignition of propane-air mixtures in different feeding modes from ambient cold-start conditions were investigated numerically with chemical kinetic model in Pt/γ-Al2O3 catalytic micro-combustors. For the steady and transient state, effect of wall thermal conductivity on self-ignition characteristics of lean hydrogen-air mixtures was presented, and hydrogenassisted combustion of propane-air mixtures was investigated numerically in the co-feed mode and the sequential feed mode. The computational results indicate the large thermal inertia of the micro-combustor solid structure leads to slow temperature dynamics, and transient response is dominated by… More >