Hanna Bialkowska-Hobrzanska, David K. Driman, Robert Fletcher, Vimla Harry, Hassan Razvi

Canadian Journal of Urology, Vol.13, No.1, pp. 2967-2974, 2006

Abstract Background: The variable clinical behavior displayed by prostate cancer (PCa) warrants investigation of potential PCa-specific biomarkers that could identify more aggressive tumor types and therefore provide prognostic value. Upregulation of expression of human telomerase reverse transcriptase (hTERT), Survivin, DD3 and PCGEM1 mRNAs in PCa lesions has recently been described. The purpose of this study was to evaluate the clinical value of detection of overexpression of these biomarkers in the diagnosis and prognosis of PCa.
Material and methods: Archival formalin-fixed, paraffin-embedded (FFPE) prostatectomy tissue from 26 patients with PCa (Gleason score 3-9, mean 7) and 14 patients with… More >

Graeme G. Duncan¹, Tom Corbett², Himu Lukka², Padraig Warde³, Tom Pickles¹

Canadian Journal of Urology, Vol.13, No.1, pp. 2962-2966, 2006

Abstract The majority of GU radiation oncologists in Canada attended a consensus meeting in November 2004. The topic of osteoporosis in men receiving androgen deprivation therapy (ADT) for prostate cancer was identified as a key theme. A chaired session with keynote speakers and review of the evidence took place followed by open debate. Participants were provided with background information.
Osteoporosis was defined as a T-score <= -2.5, but the importance of risk factors and clinical findings is noted. Dual DEXA is the current standard for assessment of bone density and relates well to fracture risk. The… More >

Gerald Brock¹, Edson D. Moreira Jr², Dale B. Glasser³, Clive Gingell⁴

Canadian Journal of Urology, Vol.13, No.1, pp. 2953-2961, 2006

Abstract Objectives: To study sexual activity, the prevalence of sexual difficulties and related help-seeking behaviors among mature adults in Canada.
Materials and methods: A telephone survey (random digit dialed) was conducted in Canada in 2001 to 2002. Interviews were based on a standardized questionnaire, including demographics, general health, relationships, and sexual behaviors, attitudes and beliefs. The survey was completed by a total of 1007 individuals (500 men and 507 women) aged 40 to 80 years in Canada.
Results: Overall, 83% of men and 71% of women had engaged in sexual intercourse during the 12 months preceding the interview, and… More >

Joseph L. Chin

Canadian Journal of Urology, Vol.13, No.1, pp. 2949-2952, 2006

Abstract This article has no abstract. More >

Scott Manatt¹, Jeffrey B. Campbell¹, Faridali Ramji², Ann Kuhn³, Dominic Frimberger¹

Canadian Journal of Urology, Vol.13, No.2, pp. 3057-3058, 2006

Abstract Inguinal herniation of the bladder is an uncommon finding with fewer than 200 cases reported in the literature. It is found most commonly in older, obese men with lower urinary tract symptoms. We report a case of inguinal herniation of the bladder in a premature infant. More >

Peter John Pommerville¹, Paul Zakus¹, Nicholas van der Westhuizen², Pamela Catherine Kibsey³

Canadian Journal of Urology, Vol.13, No.2, pp. 3044-3046, 2006

Abstract Tuberculous (TB) infections are usually limited to the pulmonary system but the hematogenous spread of TB can result in secondary infections in any part of the body. Genitourinary TB is uncommon and follows hematogenous spread from a primary pulmonary infection to the kidneys. A rare case of a TB infection of the bladder without renal involvement is described. More >

George J. Assaf

Canadian Journal of Urology, Vol.13, No.2, pp. 3034-3038, 2006

Abstract Objectives: To report our experience in the management of patients with non-palpable lesions of the testis with a review of published studies. Even though radical orchiectomy remains the golden standard treatment for solid testicular masses there is an increasing role for testes-sparing surgery in a select group of patients with non-palpable tumors.
Patients and methods: Between April 2000 and October 2004, a non-palpable testicular lesion was discovered on ultrasonography in six patients. Ultrasonography was performed for infertility in two patients, for testicular pain in three patients, and in one case for previous history of seminoma in the More >

Gilles Karsenty, Abdulaziz Baazeem, Ehab Elzayat, Jacques Corcos

Canadian Journal of Urology, Vol.13, No.2, pp. 3027-3033, 2006

Abstract The first application of botulinum toxin type A (BTA) in urology was its injection into the urinary sphincter to treat neurogenic detrusor-sphincter dyssynergia (DSD) in quadriplegic men. Since that first report in the eighties, the results of focal BTA injections into the sphincter, the bladder wall and lately into the prostate, have raised the interest of the urology community in this promising new therapeutic modality. An evidence-based review is presented of current indications, techniques and outcome of BTA injections into the urethral sphincter. More >

Kavitha Passaperuma¹, Robert Ash², Varugar Venkatesan², George Rodrigues², Eric Winquist³

Canadian Journal of Urology, Vol.13, No.2, pp. 3009-3015, 2006

Abstract Objective: Consolidative radiotherapy has improved local control in other tumors with high local recurrence rates but has not been well studied in urothelial cancer. We hypothesized that pelvic chemoradiotherapy (PCRT) given after systemic chemotherapy for metastatic bladder cancer (MTCC) might alter the pattern of disease recurrence, and reduce the complications and morbidity of intrapelvic disease relapse. A 74% locoregional relapse rate has been observed in MTCC patients with intrapelvic nodal disease after response to chemotherapy. To explore this hypothesis further, we performed a retrospective analysis and report the efficacy, toxicity and pattern of failure with this… More >

Walid A. Farhat^1,2, Jun Chen¹, Christopher Sherman³, Lisa Cartwright¹, Andre Bahoric³, Herman Yeger⁴

Canadian Journal of Urology, Vol.13, No.2, pp. 3000-3008, 2006

Abstract Purpose: Urinary bladder tissue engineering utilizing autologous cell-seeded scaffolds requires enough bladder cells to populate a large surface area which may be difficult to obtain from abnormal bladders. We evaluated whether a fibrin glue spray technique enhances cell seeded acellular matrix (ACM) repopulation in a porcine bladder model.
Materials and methods: Porcine urothelial and smooth muscle cells cultured from open bladder biopsy were sprayed with or without fibrin glue onto porcine bladder ACM. After 10 days in vitro, constructs were implanted onto porcine bladders (4/group) and harvested after 1 or 6 weeks for H&E and immunohistochemical staining.
Results: More >