Eva Villamón1, Daniel Gozalbo1, Patricia Roig1, Celia Murciano1, José Enrique O’Connor2, Didier Fradelizi3, M. Luisa Gil1
European Cytokine Network, Vol.15, No.3, pp. 263-271, 2004
Abstract We have studied the role of myeloid differentiation factor 88 (MyD88), the universal Toll-like
receptor (TLR) adaptor protein, in murine defenses against We have studied the role of myeloid differentiation factor 88 (MyD88), the universal Toll-like
receptor (TLR) adaptor protein, in murine defenses against Candida albicans. MyD88-deficient mice, experimen-tally
infected in vivo, had a very significant impaired survival, and a higher tissue fungal burden when compared
with control mice. The recruitment of neutrophils to the site of infection was also significantly diminished in
MyD88-/- mice. In vitro production of proinflammatory cytokines such as TNF-α, IFN-γ and… More >