Daniel Taussky^1,2, Felix Preisser^3,4, Pierre I. Karakiewicz^1,5, Derya Tilki^3,4, Carole Lambert^1,2, Jean-Paul Bahary^1,2, Guila Delouya^1,2, Robert Wistaff^2,6, Mikhael Laskine^2,6, Paul Van Nguyen^2,6, Madeleine Durand^2,6, Fred Saad⁵

Canadian Journal of Urology, Vol.25, No.5, pp. 9509-9515, 2018

Abstract Introduction: Conflicting data exists on the influence of metformin on prostate cancer. We investigated the importance of metformin in patients treated with radiotherapy or brachytherapy.
Materials and methods: All patients from a large institutionalized database, treated for primary localized prostate cancer with either brachytherapy or external-beam radiotherapy ± androgen deprivation therapy were identified. Groups were compared by Kaplan–Meier analyses and Cox regression models. Multivariate analysis was adjusted for CAPRA-Score, type of treatment, and age.
Results: A total of 2441 patients with complete data was identified. Among them, 382 patients (16% of total) were diabetic. Two hundred eighty-one of… More >

Abud-Archila M¹, AK Espinosa-Arrioja¹, T González-Soto², VF Gutiérrez-Oliva¹, V Ruíz-Valdiviezo¹, D González-Mendoza², L Rodríguez-Hernández³, FA Gutiérrez-Miceli¹

Phyton-International Journal of Experimental Botany, Vol.87, pp. 209-215, 2018, DOI:10.32604/phyton.2018.87.209

Abstract The aim of this investigation was to analyze the effect of vermicompost and phosphate rock on plant growth and biochemical responses of Moringa oleifera exposed to water deficit and waterlogging conditions. Treatments included 152 g of vermicompost (V) and 1.3 g of phosphate rock (PR) added to each cultivation bag. Control was prepared with 2.3 g of urea. All treatments were irrigated under different watering conditions [water deficit: irrigated at 20% water holding capacity (WHC); control (40% WHC) and waterlogging (60% WHC)]. The overall average in plant height was 90, 86 and 68 cm, whereas chlorophyll… More >

Qayyum S¹, SA Majid¹, A Bibi², A Ulfat¹, K Khanum¹, A Munir¹, S Nisar¹, S Aziz¹, N Mumtaz¹

Phyton-International Journal of Experimental Botany, Vol.87, pp. 191-197, 2018, DOI:10.32604/phyton.2018.87.191

Abstract Maize (Zea mays L., the third most important cereal crop after wheat and rice, is the major kharif (summer) crop of rainfed areas in Pakistan. The yield per hectare and total production of maize in Pakistan is low versus an exponentially increasing population. The objective of this work was to study the interactive effects of phytohormones [Gibberellic acid (GA), Sodium nitroprusside (SNP), Abscicic acid (ABA) and kinetin (KIN)] on morphological, physiological and biochemical parameters during the germination of maize seeds. Seeds were presoaked in different hormones, separately or in combinations. Priming with GA+SNP+ABA+KIN enhanced the total More >

Virginia Aragon Sanabria¹, Cheng Dong^*

Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 1-19, 2018, DOI:10.3970/mcb.2018.015.001

Abstract Endothelial barrier function is critical for tissue homeostasis throughout the body. Disruption of the endothelial monolayer leads to edema, vascular diseases and even cancer metastasis among other pathological conditions. Breakdown of the endothelial barrier integrity triggered by cytokines (e.g.IL-8,IL-1β) and growth factors (e.g.VEGF) is well documented. However, endothelial cells are subject to major biomechanical forces that affect their behavior. Due to their unique location at the interface between circulating blood and surrounding tissues, endothelial cells experience shear stress, strain and contraction forces. More than three decades ago, it was already appreciated that shear flow caused More >

Daniel R. Jeske^1,2, Jenifer A. Linehan^3,4, Timothy G. Wilson^3,4, Mark H. Kawachi³, Kristina Wittig³, Katarzya Lamparska³, Camille Amparo³, Rosa Mejia³, Fang Lai⁵, Dimitra Georganopoulou⁵, Steven S. Smith³

Canadian Journal of Urology, Vol.24, No.6, pp. 9089-9097, 2017

Abstract Introduction: Early biochemical recurrence after prostate cancer surgery is associated with higher risk of aggressive disease and cancer specific death. Many new tests are being developed that will predict the presence of indicators of aggressive disease like early biochemical recurrence. Since recurrence occurs in less than 10% of patients treated for prostate cancer, validation of such tests will require expensive testing on large patient groups. Moreover, clinical application of the validated test requires that each new patient be tested. In this report we introduce a two-stage classifier system that minimizes the number of patients that must… More >

Valle-Rodríguez CM¹, S Valdés-Rodríguez², NL Vasco-Méndez¹, C Garcidueñas-Piña¹, RE Soria-Guerra³, JF Morales-Domínguez¹

Phyton-International Journal of Experimental Botany, Vol.86, pp. 143-150, 2017, DOI:10.32604/phyton.2017.86.143

Abstract The natriuretic peptides (NP) are vertebrate hormones involved in the regulation of ion and water homeostasis in the cell. In plants, natriuretic peptides (PNP) have been identified by molecular and biochemical methods. It has been suggested that PNPs, have similar functions to the PN, since they mediate (1) ion transport through the cell, (2) the opening and closing of Na⁺ and K⁺ channels through the stimulation and synthesis of a second messenger such as cGMP, and (3) the aperture of stomata. In this study, a PNPs gene was partially identified by PCR in garlic (Allium sativum L.),… More >

Sinagawa-García SR¹, A Gutiérrez-Díez¹, A Mora-Olivo², MC Juárez-Aragón², JA Torres-Castillo²

Phyton-International Journal of Experimental Botany, Vol.84, No.2, pp. 358-367, 2015, DOI:10.32604/phyton.2015.84.358

Abstract A general biochemical description of an aqueous extract obtained from Ibervillea sonorae root was reported; furthermore, a histological description for the root is included. A bromatological analysis was carried out, and it indicated that the study nutritional variables were similar to those reported in other edible tuberous roots including sweet potatoe, mandioca, bean yam and arracacha. For the first time, the presence of an active proteinase at alkaline pH and the inhibitory activity of trypsin were reported for this root. Several medical and bioactive properties have been attributed to the wereke root. Nevertheless, deeper studies are More >

Guan Z-J^1,3,4*, S-B Lu^2*,Y-L Huo⁵, B Guo³, Z-P Guan⁶, Y-H Wei³

Phyton-International Journal of Experimental Botany, Vol.84, No.2, pp. 351-357, 2015, DOI:10.32604/phyton.2015.84.351

Abstract Leaf explants of the HBsAg-transgenic cherry tomato (Solanum lycopersicum) mutant were cultured on Murashige and Skoog (MS) basal medium, supplemented with 1.0 mg/L 6-BA and 0.05 mg/L IAA for callus induction, to clarify the physiological and biochemical characteristics of morphogenesis development. Therefore, the physiological and biochemical changes during the development of organogenic shoots and somatic embryos in the mutant were studied. Superoxide dismutase (SOD) activities of the mutant had only one peak value on the 21st day. Peroxidase (POD) activities of the mutant declined less sharply since the explants were cultured. IAA oxidase activity of… More >

Yun-Sok Ha^1,2, Dong Il Kang³, Jeong Hyun Kim⁴, Jae Young Joung⁵, Jihyeong Yu⁶, Jaspreet S. Parihar¹, Amirali Hassanzadeh Salmasi¹, Shigeo Horie⁷, Wun-Jae Kim⁸, Isaac Yi Kim¹

Canadian Journal of Urology, Vol.21, No.3, pp. 7290-7297, 2014

Abstract Introduction: Positive surgical margin (PSM) has classically been associated with biochemical recurrence (BCR) following radical prostatectomy (RP) and immediate adjuvant radiotherapy has been advocated based on two large randomized prospective clinical studies. However, a significant percentage of patients with PSM never experience BCR. This study evaluated factors potentially affecting risk of BCR among the patients with PSM after robot-assisted radical prostatectomy (RARP).
Materials and methods: From a prospectively maintained database, 699 patients with localized prostate cancer who underwent a RARP without any adjuvant therapy were identified. Median follow up was 46.0 months. To determine the pathologic and… More >

Costas D. Lallas¹, Yomi Fashola¹, Robert B. Den², Francisco Gelpi-Hammerschmidt¹, Anne E. Calvaresi¹, Peter McCue³, Ruth Birbe³, Leonard G. Gomella¹, Edouard J. Trabulsi¹

Canadian Journal of Urology, Vol.21, No.5, pp. 7479-7486, 2014

Abstract Introduction: To identify and assess predictive factors for positive surgical margins (PSM) in patients undergoing radical prostatectomy (RP).
Materials and methods: An Institution Review Board (IRB) approved retrospective review of 1751 patients that underwent RP from March 2000 to June 2013 was performed. Identified were 1740 patients whom had not received neoadjuvant therapy; these were used for the purpose of this analysis. Univariate and multivariate analysis were performed to determine factors associated with and predictive of PSMs, divided into preoperative and pathological. Variables analyzed include age, body mass index (BMI), race, surgeon, surgical modality, pathologic T-stage and… More >