Costas D. Lallas¹, Yomi Fashola¹, Robert B. Den², Francisco Gelpi-Hammerschmidt¹, Anne E. Calvaresi¹, Peter McCue³, Ruth Birbe³, Leonard G. Gomella¹, Edouard J. Trabulsi¹

Canadian Journal of Urology, Vol.21, No.5, pp. 7479-7486, 2014

Abstract Introduction: To identify and assess predictive factors for positive surgical margins (PSM) in patients undergoing radical prostatectomy (RP).
Materials and methods: An Institution Review Board (IRB) approved retrospective review of 1751 patients that underwent RP from March 2000 to June 2013 was performed. Identified were 1740 patients whom had not received neoadjuvant therapy; these were used for the purpose of this analysis. Univariate and multivariate analysis were performed to determine factors associated with and predictive of PSMs, divided into preoperative and pathological. Variables analyzed include age, body mass index (BMI), race, surgeon, surgical modality, pathologic T-stage and… More >

F. S. Tabatabaei^∗, M. Jazayeri^†, P. Ghahari^‡, N. Haghighipour^§

Molecular & Cellular Biomechanics, Vol.11, No.3, pp. 209-220, 2014, DOI:10.3970/mcb.2014.011.209

Abstract During orthodontic treatments, applied mechanical forces create strain and result in tooth movement through the alveolar bone. This response to mechanical strain is a fundamental biological reaction. The present study evaluated the effect of equiaxial strain within the range of orthodontic forces on the osteogenic differentiation of human dental pulp stem cells (hDPSCs). Following isolation and culture of hDPSCs, 3rd passage cells were transferred on a silicone membrane covered with collagen. Cell adhesion to the membrane was evaluated under scanning electron microscope (SEM). Cells were divided into three groups: the first group was placed in… More >

Bradley C. Carthon^1,2, David M. Marcus^2,3, Lindsey A. Herrel⁴, Ashesh B. Jani^2,3,4, Peter J. Rossi^2,3,4, Daniel J. Canter^2,4

Canadian Journal of Urology, Vol.20, No.3, pp. 6748-6755, 2013

Abstract Introduction: Radical prostatectomy is an effective primary treatment for clinically localized prostate cancer. While many patients are cured of their disease after surgery, there are still a significant proportion of men who will develop a biochemical recurrence (BCR). In this review, we detail existing treatment algorithms for this group of patients as well as future therapies that show great promise.
Materials and methods: A review of the literature was performed, and relevant, high-impact articles were identified and reviewed focusing on the treatment of men with BCR after surgery for prostate cancer. Wherever possible, we used data from… More >

Mark S. Soloway, Viacheslav Iremashvili, Michael A. Gorin, Ahmed Eldefrawy, Ramgopal Satyanarayana, Murugesan Manoharan

Canadian Journal of Urology, Vol.19, No.3, pp. 6280-6286, 2012

Abstract Introduction: The objective of this report is to describe the oncologic outcomes of men with margin-positive prostate cancer who were managed expectantly following radical prostatectomy.
Materials and methods: Between January 1992 and January 2011, 2166 men underwent an open radical prostatectomy by a single surgeon. Of these patients, 1592 (74%) had complete data and met the inclusion criteria of negative lymph nodes and no history of neoadjuvant or adjuvant therapy. This cohort was dichotomized by the presence or absence of at least one positive surgical margin. Groups were compared for differences in recurrence-free and overall survival.
Results: In… More >

Hong Qian^∗, Hao Ge^†

Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 1-30, 2012, DOI:10.3970/mcb.2012.009.001

Abstract Biochemical reaction systems in mesoscopic volume, under sustained environmental chemical gradient(s), can have multiple stochastic attractors. Two distinct mechanisms are known for their origins: (a) Stochastic single-molecule events, such as gene expression, with slow gene on-off dynamics; and (b) nonlinear networks with feedbacks. These two mechanisms yield different volume dependence for the sojourn time of an attractor. As in the classic Arrhenius theory for temperature dependent transition rates, a landscape perspective provides a natural framework for the system's behavior. However, due to the nonequilibrium nature of the open chemical systems, the landscape, and the attractors More >

Mohamed A. Elshaikh¹, Dina R. Ibrahim¹, Hans Stricker², James O. Peabody²

Canadian Journal of Urology, Vol.18, No.2, pp. 5592-5600, 2011

Abstract Introduction: Prostate cancer is the second most common cause of cancer death in American men. For patients with adverse pathologic features, postoperative radiotherapy to prostate bed after radical prostatectomy has been shown in randomized studies to improve many important clinical endpoints including overall survival. In this review article, we distinguish adjuvant radiation treatment (ART) from salvage radiation treatment (SRT), discuss the evidences for ART and its potential side effects focusing on the debate concerning the optimal timing of post prostatectomy radiation treatment (RT).
Material and methods: A comprehensive literature search was conducted in MEDLINE including pre-MEDLINE.
Conclusion: For More >

Abrameto MA, CM Pozzo Ardizzi, MI Gil, LM Molina

Phyton-International Journal of Experimental Botany, Vol.79, pp. 123-132, 2010, DOI:10.32604/phyton.2010.79.123

Abstract Costly investments in storage and transport of onion bulbs makes it increasingly important to identify cultivars with the best chance of long-term storage. This paper discusses our own and other researchers’ results and laboratory procedures on onion’s pungency, soluble solids, dry matter, respiration rate, carbohydrates and catabolism-related enzymes under different storage conditions. The variability in parameters such as carbohydrate composition, pungency, soluble solids and soluble uronic acid concentration in water is growth dependent, and defines the quality of onion bulbs at harvest time. During storage, these parameters can be modified by environmental conditions, presence of More >

Gary W. Bong, Thomas E. Keane

Canadian Journal of Urology, Vol.14, Suppl.6, pp. 2-9, 2007

Abstract Despite excellent success rates with radical prostatectomy and radiotherapy for the treatment of prostate cancer, a significant number of patients will experience a rise in their serum prostate specific antigen (PSA) level. A variety of salvage options in this scenario have been investigated and the choice to pursue surveillance, single therapy or combination therapy depends on clinical assessment of risk and location of tumor recurrence. After radical prostatectomy, for example, patients with low risk local disease may not require secondary therapy or may benefit from salvage radiotherapy. Those with higher risk disease, based on PSA More >

Eric Berthelet¹, Tom Pickles², Pauline T. Truong¹, Mitchell Liu³, Howard H. Pai¹, Winkle B. Kwan³, Jan T.W. Lim¹

Canadian Journal of Urology, Vol.14, No.4, pp. 3621-3627, 2007

Abstract Purpose: To evaluate the optimal duration of androgen deprivation therapy (ADT) in patients with prostate cancer treated with external beam radiotherapy (EBRT), who present with PSA levels >20 ng/mL.
Materials and methods: A total of 307 patients presenting with a PSA >20 ng/ml were treated with EBRT and ADT. The cohort was divided into four groups according to the duration of ADT: Group 1 received <6 months (n=71), group 2 received 6-12 months (n=80), group 3 received 12-24 months (n=72), and group 4 received >24 months (n=84) of ADT. The endpoints analyzed were biochemical control (bNED), overall… More >

WALTER MANUCHA

BIOCELL, Vol.31, No.1, pp. 1-12, 2007, DOI:10.32604/biocell.2007.31.001

Abstract Congenital obstructive nephropathy is the primary cause of end-stage renal disease in children. Rapid diagnosis and initiation of the treatment are vital to preserve function and/or to slow down renal injury. Obstructive uropathy effects -decline in the plasmatic renal flow and glomerular filtration rate, interstitial infiltrate of leukocytes, significant decrease of the urine concentration, loss of the capacity to concentrate urine as well as fibrosis and apoptosis- are a consequence of a variety of factors that work in complex ways and are still not fully understood. Mediators as angiotensin II, transforming growth factor-β (TGF-β) and… More >