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  • Open Access

    ARTICLE

    Effects of filgrastim on granulopoietic cells of mice pretreated with methotrexate

    LILIAN BARRIOS, OSCAR HÉCTOR POLETTI

    BIOCELL, Vol.29, No.1, pp. 7-14, 2005, DOI:10.32604/biocell.2005.29.007

    Abstract We have evaluated the effect of filgrastim on proliferation and differentiation activity of granulopoietic cells in mice pretreated with methotrexate. Filgrastim was injected daily, from day 8 to 28 after cytotoxic agent administration. The granulopoiesis changes were measured by assessment of GM-CFU cells content, marrow and spleen granuloid cells pool as well as circulating neutrophils. In MTX pretreated mice, bone marrow GM-CFU oscillating values were higher than normal values, but these changes were not followed by high proliferative activity in granuloid precursor cell compartment. After MTX treatment, filgrastim administration was unable to stimulate marrow granulopoiesis… More >

  • Open Access

    ARTICLE

    Interfacial Strength of Cement Lines in Human Cortical Bone

    X. Neil Dong1,2, Xiaohui Zhang1, X. Edward Guo1

    Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 63-68, 2005, DOI:10.3970/mcb.2005.002.063

    Abstract In human cortical bone, cement lines (or reversal lines) separate osteons from the interstitial bone tissue, which consists of remnants of primary lamellar bone or fragments of remodeled osteons. There have been experimental evidences of the cement line involvement in the failure process of bone such as fatigue and damage. However, there are almost no experimental data on interfacial properties of cement lines in human cortical bone. The objective of this study is to design and assemble a precision and computer controlled osteon pushout microtesting system, and to experimentally determine the interfacial strength of cement… More >

  • Open Access

    ARTICLE

    Computational Fluid Dynamics Modeling of the Effect Of Rotation During Reaming into the Intramedullary Canal of a Long Bone

    J. Bahen1, O. Gaber1, K. Behdinan2, J. De Beer3, P. Zalzal4, M. Papini1, M. Z. Saghir1

    FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.4, pp. 343-352, 2005, DOI:10.3970/fdmp.2005.001.343

    Abstract The penetration of the reamer into the medullary cavity can be compared to a piston entering a cylinder filled with viscous fluid. When the flutes of the reamer are clogged with bone debris, fat and marrow, the piston effect is magnified and larger pressures are usually obtained. This paper considers a reamer with clogged flutes and investigates whether the rotation speed of the reamer has a significant influence on the pressure within the intramedullary cavity. The effect of reamer rotation speed on the pressure distribution within the bone is investigated numerically by solving the full More >

  • Open Access

    ARTICLE

    Bone and Joints Modelling with Individualized Geometric and Mechanical Properties Derived from Medical Images

    M.C. Ho Ba Tho1

    CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 489-496, 2003, DOI:10.3970/cmes.2003.004.489

    Abstract The objective of the paper is to address the methodology developed to model bone and joints with individualised geometric and material properties from medical image data. An atlas of mechanical properties of human bone has been investigated demonstrating individual differences. From these data, predictive relationships have been established between mechanical properties and quantitative data derived from measurements on medical images. Subsequently, geometric and numerical models of bones with individualised geometrical and mechanical properties have been developed from the same source of image data. The advantages of this modelling technique are its ability to study the More >

  • Open Access

    ARTICLE

    A Method for Estimating Relative Bone Loads from CT Data with Application to the Radius and the Ulna

    K.J. Fischer1,2, J.A. Bastidas3, H.J. Pfaeffle2, J.D. Towers2

    CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 397-404, 2003, DOI:10.3970/cmes.2003.004.397

    Abstract The two bones of the forearm, the radius and the ulna, have been shown to bear different proportions of the overall forearm load at the wrist and the elbow. This biomechanical data suggests load transfer between the bones occurs through the soft tissues of the forearm. Load transfer from radius to ulna through passive soft tissues such as the interosseous ligament (IOL) has been experimentally measured. Ex vivo studies of the forearm, however, cannot account for the effect of internal loads generated by the muscles and, in some cases, external forces acting directly on the… More >

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