F. Li¹, X. Wang¹, X. Liao¹, C. Niyibizi¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 167-168, 2006, DOI:10.32604/mcb.2006.003.167

Abstract This article has no abstract. More >

X. Edward Guo^∗,†,‡, Erica Takai^∗,‡, Xingyu Jiang^§, Qiaobing Xu^§, George M. Whitesides^§, James T. Yardley^¶, Clark T. Hung^*, Eugene M. Chow^||, Thomas Hantschel^∗∗, Kevin D. Costa^∗

Molecular & Cellular Biomechanics, Vol.3, No.3, pp. 95-108, 2006, DOI:10.3970/mcb.2006.003.095

Abstract In this study, bone cells were successfully cultured into a micropatterned network with dimensions close to that of in vivo osteocyte networks using microcontact printing and self-assembled monolyers (SAMs). The optimal geometric parameters for the formation of these networks were determined in terms of circle diameters and line widths. Bone cells patterned in these networks were also able to form gap junctions with each other, shown by immunofluorescent staining for the gap junction protein connexin 43, as well as the transfer of gap-junction permeable calcein-AM dye. We have demonstrated for the first time, that the intracellular More >

H. Schulte-Baukloh, F. Thalau, B. Stürzebecher, H. H. Knispel

Canadian Journal of Urology, Vol.12, No.2, pp. 2581-2587, 2005

Abstract Objective: The opponents of the In-Tac™ bone anchor system note the risk of a high rate of wound infection and osteitis pubis. We evaluated whether there is a difference in the outcome of the use of two different sling materials – polyethylene and fascia lata – with regard to wound infection, and analyzed the incidence of osteitis pubis further in a larger series.
Material and methods: A total of 61 women (mean age = 65.4 years) were treated for stress urinary incontinence (SUI) type II and III using the In-Tac™ bone anchor system. In 15 of 61… More >

LILIAN BARRIOS, OSCAR HÉCTOR POLETTI

BIOCELL, Vol.29, No.1, pp. 7-14, 2005, DOI:10.32604/biocell.2005.29.007

Abstract We have evaluated the effect of filgrastim on proliferation and differentiation activity of granulopoietic cells in mice pretreated with methotrexate. Filgrastim was injected daily, from day 8 to 28 after cytotoxic agent administration. The granulopoiesis changes were measured by assessment of GM-CFU cells content, marrow and spleen granuloid cells pool as well as circulating neutrophils. In MTX pretreated mice, bone marrow GM-CFU oscillating values were higher than normal values, but these changes were not followed by high proliferative activity in granuloid precursor cell compartment. After MTX treatment, filgrastim administration was unable to stimulate marrow granulopoiesis… More >

X. Neil Dong^1,2, Xiaohui Zhang¹, X. Edward Guo¹

Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 63-68, 2005, DOI:10.3970/mcb.2005.002.063

Abstract In human cortical bone, cement lines (or reversal lines) separate osteons from the interstitial bone tissue, which consists of remnants of primary lamellar bone or fragments of remodeled osteons. There have been experimental evidences of the cement line involvement in the failure process of bone such as fatigue and damage. However, there are almost no experimental data on interfacial properties of cement lines in human cortical bone. The objective of this study is to design and assemble a precision and computer controlled osteon pushout microtesting system, and to experimentally determine the interfacial strength of cement… More >

J. Bahen¹, O. Gaber¹, K. Behdinan², J. De Beer³, P. Zalzal⁴, M. Papini¹, M. Z. Saghir¹

FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.4, pp. 343-352, 2005, DOI:10.3970/fdmp.2005.001.343

Abstract The penetration of the reamer into the medullary cavity can be compared to a piston entering a cylinder filled with viscous fluid. When the flutes of the reamer are clogged with bone debris, fat and marrow, the piston effect is magnified and larger pressures are usually obtained. This paper considers a reamer with clogged flutes and investigates whether the rotation speed of the reamer has a significant influence on the pressure within the intramedullary cavity. The effect of reamer rotation speed on the pressure distribution within the bone is investigated numerically by solving the full More >

Fred Saad¹, Kim Chi², Neil Fleshner³

Canadian Journal of Urology, Vol.11, No.5, pp. 2376-2382, 2004

Abstract Bone metastases are associated with significant skeletal-related morbidity that negatively correlates with quality of life and survival in patients with prostate cancer. Once prostate cancer has metastasized to bone, the median survival of patients is approximately 30 to 53 months; therefore, the chronic consequences of bone complications must be taken into consideration when developing long-term therapeutic strategies in this patient population. In addition to the bone-damaging effects of metastases, bone loss related to long-term hormonal therapy, as well as age-related bone loss, further compromise bone integrity in patients with advanced prostate cancer.
This article reviews the More >

Victor H. Hartanto, David DiPiazza, Murali K. Ankem, Carmen Baccarini, Nancy J. Lobby

Canadian Journal of Urology, Vol.10, No.1, pp. 1759-1763, 2003

Abstract Materials and methods: A total of 64 women (mean age = 57) were treated for stress urinary incontinence secondary to intrinsic sphincter deficiency or hypermobility between March 1998 to August 2000. Group I (SPWS) consisted of 30 patients who underwent in situ vaginal wall sling with suprapubic placement of bone anchors in the pubic tubercle utilizing the Vesica system. Group II (TVCS) consisted of 34 patients who underwent cadaveric fascia sling with transvaginal placement of bone anchors behind the symphysis pubis utilizing the Precision-TAC system. Phone interviews were conducted by a third party who was blinded… More >

M.C. Ho Ba Tho¹

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 489-496, 2003, DOI:10.3970/cmes.2003.004.489

Abstract The objective of the paper is to address the methodology developed to model bone and joints with individualised geometric and material properties from medical image data. An atlas of mechanical properties of human bone has been investigated demonstrating individual differences. From these data, predictive relationships have been established between mechanical properties and quantitative data derived from measurements on medical images. Subsequently, geometric and numerical models of bones with individualised geometrical and mechanical properties have been developed from the same source of image data. The advantages of this modelling technique are its ability to study the More >

K.J. Fischer^1,2, J.A. Bastidas³, H.J. Pfaeffle², J.D. Towers²

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 397-404, 2003, DOI:10.3970/cmes.2003.004.397

Abstract The two bones of the forearm, the radius and the ulna, have been shown to bear different proportions of the overall forearm load at the wrist and the elbow. This biomechanical data suggests load transfer between the bones occurs through the soft tissues of the forearm. Load transfer from radius to ulna through passive soft tissues such as the interosseous ligament (IOL) has been experimentally measured. Ex vivo studies of the forearm, however, cannot account for the effect of internal loads generated by the muscles and, in some cases, external forces acting directly on the… More >