Rafael Martins de OLIVEIRA, Carolina Bernardi STEFANI, Angélica Aparecida Antoniellis SILVEIRA, Marcelo Lima RIBEIRO, José PEDRAZZOLI Jr., Alessandra GAMBERO^*

BIOCELL, Vol.39, No.2-3, pp. 5-8, 2015, DOI:10.32604/biocell.2015.39.005

Abstract Adenosine acts as a gastroprotective factor decreasing inflammation and reducing gastric acid secretion. Quantitative RT-PCR was used to determine the expression of the adenosine receptor genes (A1AR, A2AAR, A2BAR and A3AR) and that of the gastrin receptor B gene (CCKBR) in isolated, short-term cultured enterochromaffin-like (ECL) cells. Both the A1AR and the CCKBR genes were expressed at a level higher than the other genes. Also, the effect of 2-chloroadenosine, a stable agonist of A1 and A2A receptors, was explored on ECL cells, with a resulting inhibition of both basal and gastrin-stimulated histamine release. Also, dipropylcyclopentylxanthine (DPCPX), a More >

Zhengzheng Cao¹, Yuejin Zhou^1,2

CMC-Computers, Materials & Continua, Vol.48, No.2, pp. 77-90, 2015, DOI:10.3970/cmc.2015.048.077

Abstract Reasonable width design of narrow coal pillar is the key for ensuring stability of surrounding rock in the roadway driving along next goaf. Based on movement characteristics of overlying strata in gob-side entry, the paper establishes the mechanical model of surrounding rock structure for roadway driving along next goaf, and analyzes the interaction mechanism between key blocks and coal pillar. Besides, in allusion to the mechanical equilibrium of key block B in basic roof, the stability coefficients K₁ and K₂ of key block B and sensitive coefficient of influencing factor are introduced. When the stability coefficient K₁ is… More >

Cao Zhengzheng¹, Zhou Yuejin^1,2, Zhang Qi¹, Wang Erqian¹

CMC-Computers, Materials & Continua, Vol.47, No.3, pp. 203-215, 2015, DOI:10.3970/cmc.2015.047.203

Abstract Gas fracturing technology is the key to the exploration for unconventional petroleum resources and other engineering industries, so the research on the coupled gas-solid-thermal model during rock damage has the important significance to the development of gas fracturing technology. By introducing rock damage variable, the coupled gas-solid-thermal model during rock damage is established in this paper, besides, the rock damage constitutive is written with MATLAB software, which is embedded in the multi-physics coupling software COMSOL in the process of numerical computation. Based on this, the damage rule of rock mass around drilling under high pressure… More >

M. Dehghan¹, M. Abbaszadeh², A. Mohebbi³

CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.6, pp. 481-516, 2015, DOI:10.3970/cmes.2015.107.481

Abstract In the current paper the two-dimensional time fractional Klein-Kramers equation which describes the subdiffusion in the presence of an external force field in phase space has been considered. The numerical solution of fractional Klein-Kramers equation is investigated. The proposed method is based on using finite difference scheme in time variable for obtaining a semi-discrete scheme. Also, to achieve a full discretization scheme, the Kansa's approach and meshless local Petrov-Galerkin technique are used to approximate the spatial derivatives. The meshless method has already proved successful in solving classic and fractional differential equations as well as for… More >

Jianhang Du^1,2,3, Liang Wang⁴

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249

Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was… More >

Maryam Jazayeri¹, Mohammad Ali Shokrgozar¹, Nooshin Haghighipour^1,2, Reza Mahdian³, Mehdi Farrokhi¹, Shahin Bonakdar¹, FereshtehMirahmadi¹, Tannaz Nourizadeh Abbariki

Molecular & Cellular Biomechanics, Vol.12, No.3, pp. 197-213, 2015, DOI:10.3970/mcb.2015.012.197

Abstract The osseous tissue repair and regeneration have great importance in orthopedic and maxillofacial surgery. Tissue engineering makes it possible to cure different tissue abnormalities using autologous grafts. It is now obvious that mechanical loading has essential role in directing cells to differentiation. In this study, the influence of cyclic uniaxial loading and its combination with chemical factors on expression of osteogenic markers was investigated. Rat bone marrow-derived stem cells were isolated and cultured. In one group cells were maintained in chemical induction medium. In another group cells were subjected to cyclic uniaxial strain with 3%… More >

Tushar Kulkarni^1,2, Rashmi Uddanwadiker¹

Molecular & Cellular Biomechanics, Vol.12, No.3, pp. 147-195, 2015, DOI:10.3970/mcb.2015.012.147

Abstract Continuous growth in industrialization and lack of awareness in safety parameters the cases of amputations are growing. The search of safer, simpler and automated prosthetic arms for managing upper limbs is expected. Continuous efforts have been made to design and develop prosthetic arms ranging from simple harness actuated to automated mechanisms with various control options. However due the cost constraints, the automated prosthetic arms are still out of the reach of needy people. Recent data have shown that there is a wide scope to develop a low cost and light weight upper limb prosthesis. This… More >

Heng Zuo^*, Dalin Tang^*,†,‡, Chun Yang^*,§, Glenn Gaudette^¶, Kristen L. Billiar^¶, Pedro J. del Nidok^II

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 67-85, 2015, DOI:10.3970/mcb.2015.012.067

Abstract Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. Myocardial tissue regeneration techniques are being developed for the potential that viable myocardium may be regenerated to replace scar tissues in the heart or used as patch material in heart surgery. 3D computational RV/LV/Patch models with fluid-structure interactions (FSI) were constructed based on data from a healthy dog heart to obtain local fluid dynamics and structural stress/strain information and identify optimal conditions under which tissue regeneration techniques could… More >

Tong Li^∗, Prasad KDV Yarlagadda^∗, Adekunle Oloyede^∗, Namal Thibbotuwawa^∗, YuanTong Gu^∗,†

Molecular & Cellular Biomechanics, Vol.12, No.1, pp. 17-35, 2015, DOI:10.3970/mcb.2015.012.017

Abstract Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance More >

E-N.G. Grylonakis¹, C.K. Filelis-Papadopoulos¹, G.A. Gravvanis¹

CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.6, pp. 505-517, 2015, DOI:10.3970/cmes.2015.109.505

Abstract A new transform method for solving boundary value problems in two dimensions was proposed by A.S. Fokas, namely the unified transform. This approach seeks a solution to the unknown boundary values by solving a global relation, using the known boundary data. This relation can be used to characterize the Dirichlet to Neumann map. For the numerical solution of the global relation, a collocation-type method was recently introduced. Hence, the considered method is used for solving the 2D Laplace equation in several irregular convex polygons. The linear system, resulting from the collocation-type method, was solved by More >