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  • Open Access

    ARTICLE

    Overexpression of SASH1 Inhibits TGF-β1-Induced EMT in Gastric Cancer Cells

    Wei Zong*, Chen Yu, Ping Wang*, Lei Dong

    Oncology Research, Vol.24, No.1, pp. 17-23, 2016, DOI:10.3727/096504016X14570992647203

    Abstract The epithelial–mesenchymal transition (EMT) is considered to be one of the critical steps in gastric cancer cell invasion and metastasis. SAM- and SH3-domain containing 1 (SASH1), a member of the SLY family of signal adapter proteins, is a candidate for tumor suppression in several cancers. However, the biological role of SASH1 in gastric cancer remains largely unknown. Therefore, the purpose of this study was to investigate the impact of SASH1 on the biological behavior of gastric cancer cells treated with transforming growth factor (TGF)-β1. In the current study, we provide evidence that SASH1 was lowly More >

  • Open Access

    ARTICLE

    miR-1908 Overexpression Inhibits Proliferation, Changing Akt Activity and p53 Expression in Hypoxic NSCLC Cells

    Yuefeng Ma*, Jie Feng, Xin Xing, Bin Zhou*, Shaomin Li*, Wei Zhang*, Jiantao Jiang*, Jin Zhang*, Zhe Qiao*, Liangzhang Sun*, Zhenchuan Ma*, Ranran Kong*

    Oncology Research, Vol.24, No.1, pp. 9-15, 2016, DOI:10.3727/096504016X14570992647168

    Abstract The ribosomal protein (RP)–p53 pathway has been shown to play a key role in apoptosis and senescence of cancer cells. miR-1908 is a newly found miRNA that was reported to have prognostic potential in melanoma. However, its role and mechanism in the progression of non-small cell lung cancer (NSCLC) are largely unknown. In this study, we found that expression of miR-1908 was significantly downregulated in human NSCLC cell lines, including SK-MES-1, A549, and NCI-H460. Then the role of miR-1908 in NSCLC cell proliferation was explored. The miR-1908 mimic was transfected into NSCLC cell lines, and… More >

  • Open Access

    ARTICLE

    UREA-WATER DROPLET PHASE CHANGE AND REACTION MODELLING: MULTI-COMPONENT EVAPORATION APPROACH

    Viraj S. Shirodkar*

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-8, 2016, DOI:10.5098/hmt.7.5

    Abstract Urea-water solution droplet evaporation is modelled using multi-component droplet evaporation approach. The heat and mass transfer process of a multi-component droplet is implemented in the Langrangian framework through a custom code in ANSYS-Fluent R15. The evaporation process is defined by a convection-diffusion controlled model which includes the effect of Stefan flow. A rapid mixing model assumption is used for the droplet internal physics. The code is tested on a single multi-component droplet and the predicted evaporation rates at different ambient temperatures are compared with the experimental data in the literature. The approach is used to More >

  • Open Access

    ARTICLE

    COMBINED EFFECTS OF HALL, JOULE HEATING AND THERMAL DIFFUSION ON MIXED CONVECTION FLOW IN A VERTICAL CHANNEL SATURATED WITH COUPLE STRESS FLUID

    K. Kaladhara,∗, D. Srinivasacharyab

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-10, 2016, DOI:10.5098/hmt.7.6

    Abstract This present investigation carried out the effects of Hall current, Joule heating and the thermal diffusion on mixed convection flow of electrically conducting couple stress fluid in a vertical channel saturated with porous medium. The final system of ordinary differential equations are obtained from the governing non-linear partial differential equations by using the similarity transformations. Homotopy Analysis Method has been used to solve the non-linear system. The average residue errors of the HAM solutions are presented through graphs. The influence of the emerging parameters (Hall, Soret, magnetic and the couple stress parameters) on velocity, temperature More >

  • Open Access

    ARTICLE

    MULTICOMPONENT GAS-PARTICLE FLOW AND HEAT/MASS TRANSFER INDUCED BY A LOCALIZED LASER IRRADIATION ON A URETHANE-COATED STAINLESS STEEL SUBSTRATE

    Nazia Afrina, Yijin Maoa, Yuwen Zhanga,*, J. K. Chena, Robin Ritterb, Alan Lampsonb, Jonathan Stohsc

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-8, 2016, DOI:10.5098/hmt.7.7

    Abstract A three-dimensional numerical simulation is conducted for a complex process in a laser-material system, which involves heat and mass transfer in a compressible gaseous phase and chemical reaction during laser irradiation on a urethane paint coated on a stainless steel substrate. A finite volume method (FVM) with a co-located grid mesh that discretizes the entire computational domain is employed to simulate the heating process. The results show that when the top surface of the paint reaches a threshold temperature of 560 K, the polyurethane starts to decompose through chemical reaction. As a result, combustion products CO2, More >

  • Open Access

    ARTICLE

    HEAT AND MASS TRANSFER ON MHD NANOFLUID FLOW PAST A VERTICAL POROUS PLATE IN A ROTATING SYSTEM

    P.V. Satya Narayanaa,*, B.Venkateswarlub

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-10, 2016, DOI:10.5098/hmt.7.8

    Abstract In this paper, we study the chemical reaction and heat source effects on unsteady MHD free convection heat and mass transfer of a nanofluid flow past a semi-infinite flat plate in a rotating system. The plate is assumed to oscillate in time with steady frequency so that the solutions of the boundary layer are the similar oscillatory type. The innovation of the present work is closed-form analytic solutions are obtained for the momentum, energy and concentration equations. The influence of various parameters entering into the problem in the nanofluid velocity, temperature and concentration distributions, as More >

  • Open Access

    ARTICLE

    CHEMICAL REACTION AND RADIATION EFFECTS ON UNSTEADY MHD MICROPOLAR FLUID FLOW OVER A VERTICAL PLATE WITH VARIABLE TEMPERATURE

    Mekonnen Shiferaw Ayano*, J. S. Mathunjwa

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-6, 2016, DOI:10.5098/hmt.7.9

    Abstract This paper presents a study of the Magnetohydrodynamic flow of incompressible micropolar fluid past an infinite vertical porous plate with combined heat and mass transfer. The plate oscillate harmonically in its own plane and the temperature raised linearly with respect to time. Numerical calculations are carried out for different values of dimensionless parameters and an analysis of the results shown graphically and in table form. It is found that velocity and microrotation influenced appreciatively with parameters like radiation, magnetic, chemical reaction and coupling numbers. It is also noted that microrotation highly influenced by the magnetic More >

  • Open Access

    ARTICLE

    EFFECTS OF CHEMICAL REACTION AND THERMAL RADIATION ON HEAT GENERATED STRETCHING SHEET IN A COUPLE STRESS FLUID FLOW

    G. Nagarajua,† , Anjanna Mattab, K. Kaladharc

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-5, 2016, DOI:10.5098/hmt.7.11

    Abstract A theoretical steady of two-dimensional and MHD couple stress fluid flow over a linearly stretching sheet is investigated with the effects of thermal radiation, internal heat generation and homogeneous chemical reaction of first order. The governing equations of continuity, momentum, energy and diffusion for this boundary layer flow are transformed into one set of coupled non-linear ordinary differential equations using the local similarity transformation and are then solved using the fourth-order Runge-Kutta method along with the shooting technique. The effects of the couple stress parameter (S), Magnetic parameter (M) and chemical reaction parameter (Cr) are presented through More >

  • Open Access

    ARTICLE

    MHD UNSTEADY FLOW OF A WILLIAMSON NANOFLUID IN A VERTICAL POROUS SPACE WITH OSCILLATING WALL TEMPERATURE

    D. Lourdu Immaculatea , R. Muthurajb,*, Anant Kant Shuklac, S. Srinivasd

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-14, 2016, DOI:10.5098/hmt.7.12

    Abstract This article aims to examine the MHD unsteady flow of Williamson nanofluid in a vertical channel filled with a porous material and oscillating wall temperature. The modeling of this problem is transformed to ordinary differential equations by collecting the non-periodic and periodic terms and then series solutions are obtained by using a powerful method known as the homotopy analysis method (HAM). The influence of involved parameters on heat and mass transfer characteristics of the fluid flow is computed and presented graphically. Further, variations on volume flow rate, coefficient of skin friction, heat transfer rate and More >

  • Open Access

    ARTICLE

    DUAL SOLUTIONS FOR HEAT AND MASS TRANSFER IN MHD JEFFREY FLUID IN THE PRESENCE OF HOMOGENEOUSHETEROGENEOUS REACTIONS

    C. S. K. Rajua , N. Sandeepa, J. Prakashb,1

    Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-8, 2016, DOI:10.5098/hmt.7.14

    Abstract In this study, we analyzed the effects of nonlinear thermal radiation and induced magnetic field on steady two-dimensional incompressible flow of Jeffrey fluid flow past a stretching/shrinking surface in the presence of homogeneous-heterogeneous reactions. For physical relevance in this study we analyzed the behavior of homogeneous and heterogeneous profiles individually. The transformed governing equations with the help of similarity variables are solved numerically via Runge-Kutta and Newton’s method. We obtained better accuracy of the present results by differentiating with the existed published literature. The effect of pertinent parameters on velocity, induced magnetic field, temperature and More >

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