Carlos Erik Medina Santos¹, Carmen Nathaly López Hurtado¹, Bruno Rivas Santiago¹, Roberto Gonzalez-Amaro³, Yolanda Guadalupe Cataño Cañizales¹, Margarita de la Luz Martínez Fierro², José Antonio Enciso-Moreno¹, Mariana Haydee García Hernández¹

European Cytokine Network, Vol.27, No.3, pp. 68-74, 2016, DOI:10.1684/ecn.2016.0379

Abstract The aim of this study was to evaluate the effects of the LL-37, HNP-1 and HBD2/3 peptides on cytokine and MMP production in human polymorphonuclear cells, mononuclear cells and chondrocytes. The levels of cytokines in supernatants from mononuclear and polymorphonuclear cell cultures were measured with a cytometric bead array by flow cytometry. Likewise, the levels of metalloproteinase/MMP-1, 3, and 13 were measured in supernatants from chondrocyte cultures using an ELISA. The expression of RANKL on lymphocytes was analyzed by flow cytometry. We observed increased levels of TNF-α, IL-6 and IL-10 in mononuclear and polymorphonuclear cell… More >

Hui Lu, Rong Wang, Wenbin Li, Hua Xie, Chang Wang, Ying Hao, Yuhuan Sun, Zhengping Jia

European Cytokine Network, Vol.27, No.4, pp. 90-96, 2016, DOI:10.1684/ecn.2016.0383

Abstract Extensive studies have been performed on acute mountain sickness (AMS), but biomarkers predicting AMS are lacking. Presently, the mainstay methods to identify AMS biomarkers include proteomic and genetic methods at high altitudes or in hypoxic simulated chambers. In the present study, we compared plasma cytokine profiles between AMS-susceptible individuals and AMS-resistant individuals at low altitude by cytokine array analysis. In total, 75 differentially expressed cytokines were identified between AMS-susceptible individuals and AMS-resistant individuals, most involved in inflammation. A quantifiable human custom cytokine antibody array was then used to further test results of cytokine array analysis.… More >

John M. Lacy¹, Lauren N. Hendrix¹, Raevti Bole², Enmar Habib³, Cole W. Wootton¹, Ali M. Ziada¹

Canadian Journal of Urology, Vol.23, No.1, pp. 8184-8187, 2016

Abstract Introduction: Hypospadias complications, most notably meatal stenosis, are commonly reported to occur after tubularized incised plate (TIP) hypospadias repair. We focus on a point of technique in TIP repair and its effect on outcome of this possible complication, as well as other commonly reported complications. Meatal stenosis after TIP can be avoided if the urethra and overlying glans are dissected and sutured separately with no attempt at cross suturing whether the urethra ends below, behind, or above the glans sutures. This hypothesis was evaluated by a prospective data collection before and after implementation to evaluate the… More >

Jack Barkin¹, Shelley Burton², Carole Lambert³

Canadian Journal of Urology, Vol.23, No.1, pp. 8179-8183, 2016

Abstract The gonadotropin-releasing hormone (GnRH) receptor antagonist degarelix has several unique characteristics compared to luteinizing hormone-releasing hormone (LHRH) analogs used in the management of prostate cancer. Notable differences of GnRH receptor antagonists include no flare reaction, and a more rapid suppression of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prostate-specific antigen (PSA) compared to LHRH analogs. Despite emerging evidence supporting the use of GnRH receptor antagonists over the more widely used LHRH analogs in the management of prostate cancer, physicians may be reluctant to prescribe degarelix. They may be concerned about patient complaints about More >

Iryna Makovey, Robert Dolinga, Daniel A. Shoskes

Canadian Journal of Urology, Vol.23, No.1, pp. 8176-8178, 2016

Abstract Psychological factors may play a role in the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome (CP/ CPPS). This case series describes a cohort of 10 men presenting with CP/CPPS whose symptoms began after an extramarital sexual encounter, who strongly believed they had a sexually transmitted infection (STI) despite negative testing, and who have had no improvement with empiric antibiotic treatment. Patients’ clinical presentation and physical exam findings are reviewed. All men were clinically phenotyped with the UPOINT system. Pelvic floor spasm and not infection was prominent in these men. Treatment recommendations are proposed and compliance More >

Christopher M. Russell^*, Pranav Sharma^*, Gautum Agarwal, John S. Fisher, George J. Richard, Philippe E. Spiess, Julio M. Pow-Sang, Michael A. Poch, Wade J. Sexton

Canadian Journal of Urology, Vol.23, No.1, pp. 8127-8134, 2016

Abstract Introduction: To evaluate whether varying degrees of seminomatous elements in the primary orchiectomy specimen would be predictive of patient morbidity during post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) since the desmoplastic reaction with seminoma is associated with increased intraoperative complexity.
Materials and methods: We retrospectively identified 127 patients who underwent PC-RPLND for residual retroperitoneal masses. Clinicodemographic, intraoperative, and 30 day postoperative outcomes were compared for patients with pure seminoma (SEM), mixed germ cell tumors (GCT) containing seminoma elements (NS+SEM), and tumors with no seminoma elements (NS). Multivariate logistic regression was used to determine independent predictors of intraoperative and… More >

Claudio Spinelli¹, Silvia Strambi¹, Marga Busetto¹, Leonardo Rossi¹, Jessica Piscioneri¹, Angela Pucci², Francesco Bianco³

Canadian Journal of Urology, Vol.23, No.2, pp. 8254-8259, 2016

Abstract Introduction: The aim of our study is to compare two different surgical procedures, lymphatic vessels and arterioles sparing microsurgical inguinal varicocelectomy (LASMIV) without delivery of the testis and LASMIV with delivery of the testis and ligature of collateral and gubernacular veins.
Materials and methods: Seventy adolescents suffering from varicocele and reduction of the ipsilateral testicular volume greater than 20% were prospectively assigned to two homogenous groups according to age and Tanner stage. The patients, operated from 2008 to 2013, were randomized to undergo either LASMIV without delivery of the testis or LASMIV with delivery and ligature of… More >

Nishant Patel¹, Jason Woo¹, Michael A. Liss¹, Kerrin L. Palazzi¹, J. Michael Randall², Reza Mehrazin³, Ramzi Jabaji¹, Hossein S. Mirheydar¹, Kyle Gillis¹, Hak J. Lee¹, Anthony L. Patterson³, Christopher J. Kane¹, Frederick Millard², Ithaar H. Derweesh¹

Canadian Journal of Urology, Vol.23, No.2, pp. 8227-8233, 2016

Abstract Introduction: To compare surgical complications and tyrosine kinase inhibitor (TKI)-toxicities in patients who underwent primary cytoreductive nephrectomy (CN) followed by adjuvant TKI therapy versus those who underwent neoadjuvant TKI therapy prior to planned CN for metastatic renal cell carcinoma (mRCC).
Materials and methods: Two-center retrospective analysis. Sixty-one mRCC patients underwent TKI therapy with sunitinib between July 2007 to January 2014. Patients were divided into three groups: primary CN followed by adjuvant TKI (n = 27, Group 1), neoadjuvant TKI prior to CN (n = 21, Group 2), and primary TKI alone (no surgery, n = 13, Group… More >

Kevin J. Rycyna¹, Daniel Casella², Louis D’Agostino¹

Canadian Journal of Urology, Vol.23, No.3, pp. 8318-8320, 2016

Abstract Chyluria is an uncommon clinical entity outside of the tropics. We present a rare case of blunt force trauma leading to the formation of a lymphorenal fistula. This was successfully managed via conservative endoscopic and dietary treatment. More >

Zenon Pogorelić^1,2, Karla Gudelj², Dražen Budimir¹, Jakov Todorić¹, Miro Jukić¹, Dubravko Furlan¹, Đurđica Košuljandić³, Marijan Saraga^2,3

Canadian Journal of Urology, Vol.23, No.3, pp. 8312-8317, 2016

Abstract Introduction: The objective of this study was to compare the clinical efficacy of two similar tissue bulking agents, Deflux and Vurdex, used for treatment of vesicoureteral reflux (VUR) in our institution.
Material and methods: The case records of 104 children, treated endoscopically for primary VUR from January 2010 to January 2015, were retrospectively reviewed. Most of the patients were treated with Deflux until 2012, when use of Vurdex was started. Exclusion criteria were patients with secondary reflux due to neurogenic bladder, duplicated refluxing ureters, primarily operated patients and patients operated after first or second injection.
Results: Endoscopic treatment… More >