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  • Open Access

    ARTICLE

    ABCB5–ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells

    Juntao Yao*†, Xuan Yao, Tao Tian*, Xiao Fu*, Wenjuan Wang*, Suoni Li§, Tingting Shi*, Aili Suo*, Zhiping Ruan*, Hui Guo*, Kejun Nan*, Xiongwei Huo

    Oncology Research, Vol.25, No.3, pp. 305-316, 2017, DOI:10.3727/096504016X14734149559061

    Abstract ABCB5 belongs to the ATP-binding cassette (ABC) superfamily, which is recognized for playing a role in the failure of chemotherapy. ABCB5 has also been found to be overexpressed at the transcriptional level in a number of cancer subtypes, including breast cancer. However, the exact mechanism ABCB5 uses on cancer cell metastasis is still unclear. In the present study, we demonstrate that ABCB5 expression was increased in metastatic tissues when compared with nonmetastatic tissues. ABCB5 can significantly enhance metastasis and epithelial–mesenchymal transition (EMT), while knockdown of ABCB5 inhibited these processes. Microarray analysis indicated that ZEB1 may More >

  • Open Access

    ARTICLE

    Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial–Mesenchymal Transition and Cellular Migration in Glioblastoma Cells

    Jianpeng Liu*, Wei Li, Shunshun Liu*, Xu Zheng*, Lin Shi*, Weitao Zhang*, Hongfa Yang*

    Oncology Research, Vol.25, No.2, pp. 225-232, 2017, DOI:10.3727/096504016X14732772150587

    Abstract Collagen triple helix repeat containing 1 (CTHRC1), an extracellular matrix-related protein, has been found to be upregulated in many solid tumors and contributes to tumorigenesis. We found that CTHRC1 is overexpressed in glioblastoma tissues and cells. By using the technique of RNA interference, the expression of CTHRC1 in the human glioblastoma U-87MG cell line was downregulated, and the proliferation and migration of U-87MG cells were examined. The results showed that the knockdown of CTHRC1 exerts inhibitory effects on the proliferation and migration ability of U-87MG cells. Knockdown of CTHRC1 expression in U-87MG cells resulted in More >

  • Open Access

    ARTICLE

    Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells

    Jie Huang*, Li Guo

    Oncology Research, Vol.25, No.2, pp. 167-176, 2017, DOI:10.3727/096504016X14732772150307

    Abstract Sex-determining region Y (SRY)-box 9 (SOX9) is a member of the SOX transcription factor family. Increasing evidence has reported that SOX9 plays different roles in various types of malignancies. However, the role of SOX9 in papillary thyroid cancer (PTC) is still unclear. The aim of this study was to investigate the role of SOX9 in PTC. Our results showed that SOX9 was upregulated in PTC tissues and cell lines. In addition, knockdown of SOX9 significantly inhibited PTC proliferation, colony formation, migration, and invasion, as well as epithelial–mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells. More >

  • Open Access

    ARTICLE

    Depletion of NFBD1/MDC1 Induces Apoptosis in Nasopharyngeal Carcinoma Cells Through the p53–ROS–Mitochondrial Pathway

    Zhihai Wang*, Kui Liao, Wenqi Zuo*, Xueliang Liu*, Zhili Qiu*, Zhitao Gong*, Chuan Liu*, Quan Zeng*, Yi Qian*, Liang Jiang*, Youquan Bu, Suling Hong*, Guohua Hu*

    Oncology Research, Vol.25, No.1, pp. 123-136, 2017, DOI:10.3727/096504016X14732772150226

    Abstract NFBD1, a signal amplifier of the p53 pathway, is vital for protecting cells from p53-mediated apoptosis and the early phase of DNA damage response under normal culture conditions. Here we investigated its expression in patients with nasopharyngeal carcinoma (NPC), and we describe the biological functions of the NFBD1 gene. We found that NFBD1 mRNA and protein were more highly expressed in NPC tissues than in nontumorous tissues. To investigate the function of NFBD1, we created NFBD1-depleted NPC cell lines that exhibited decreased cellular proliferation and colony formation, an increase in their rate of apoptosis, and More >

  • Open Access

    ARTICLE

    Silencing of Armadillo Repeat-Containing Protein 8 (ARMc8) Inhibits TGF-β-Induced EMT in Bladder Carcinoma UMUC3 Cells

    Xuan Liang*, Qun-Li Men, Yong-wei Li, He-Cheng Li§, Tie Chong§, Zhao-lun Li§

    Oncology Research, Vol.25, No.1, pp. 99-105, 2017, DOI:10.3727/096504016X14719078133609

    Abstract Armadillo repeat-containing protein 8 (ARMc8) is a key factor in regulating cell migration, proliferation, tissue maintenance, and tumorigenesis. However, its role in bladder cancer remains unknown. Thus, in this study we sought to investigate the effect of ARMc8 on the epithelial-to-mesenchymal transition (EMT) progress in bladder cancer cells induced by transforming growth factor-b1 (TGF-β1). Our results found that ARMc8 was highly expressed in bladder cancer cell lines. ARMc8 silencing inhibited the TGF-β1-induced migration and invasion and suppressed the EMT progress in bladder cancer cells. Furthermore, ARMc8 silencing inhibited the TGF-β1-induced expression of β-catenin, cyclin D1, More >

  • Open Access

    ARTICLE

    Identification of Sensitivity Predictors of Neoadjuvant Chemotherapy for the Treatment of Adenocarcinoma of Gastroesophageal Junction

    Shoumiao Li*†, Baozhong Li, Jiaxiang Wang*, Da Zhang*, Zhiqiang Liu, Zhizhong Zhang, Wei Zhang, Yunjie Wang, Dongxiao Bai, Jianyun Guan, Yong Zhang

    Oncology Research, Vol.25, No.1, pp. 93-97, 2017, DOI:10.3727/096504016X14719078133564

    Abstract The identification of reliable predictors of chemotherapy sensitivity and early screening of adenocarcinoma of gastroesophageal junction (AGEJ) patients who are resistant to chemotherapy has become an important area of clinical and translational research. We aimed to investigate the predictive value of seven cancerassociated cellular proteins for neoadjuvant chemotherapy in AGEJ patients. Clinical data of 93 patients who received neoadjuvant chemotherapy for locally advanced AGEJ between June 2010 and December 2014 were reviewed. All patients were administered the combination regimen of S-1 and oxaliplatin (SOX). Expression of P-glycoprotein (P-gp), glutathione S-transferase-p (GST-π), topoisomerase II (topo II),… More >

  • Open Access

    ARTICLE

    RASSF4 Overexpression Inhibits the Proliferation, Invasion, EMT, and Wnt Signaling Pathway in Osteosarcoma Cells

    Minglei Zhang*, Dapeng Wang, Tongtong Zhu*, Ruofeng Yin*

    Oncology Research, Vol.25, No.1, pp. 83-91, 2017, DOI:10.3727/096504016X14719078133447

    Abstract RASSF4, a member of the RASSF family, is broadly expressed in normal tissues but often inactivated in human cancers. Despite various studies on RASSF4, its role in osteosarcoma remains unclear. Therefore, in this study, we investigated the effects of RASSF4 expression on osteosarcoma cells and explored the underlying mechanism. The results of our study showed that RASSF4 was lowly expressed in osteosarcoma tissues and cells. RASSF4 overexpression significantly inhibited proliferation, migration, and invasion as well as the EMT process in osteosarcoma cells. Meanwhile, we found that RASSF4 overexpression markedly decreased the protein expression of β-catenin, More >

  • Open Access

    ARTICLE

    Overexpression of Aristaless-Like Homeobox-4 Inhibits Proliferation, Invasion, and EMT in Hepatocellular Carcinoma Cells

    Yao Shi*, Xiaoke Sun, Xiafen He

    Oncology Research, Vol.25, No.1, pp. 11-18, 2017, DOI:10.3727/096504016X14685034103833

    Abstract Aristaless-like homeobox-4 (ALX4), a member of the Aristaless-like homeobox family, has been found to be involved in tumor cell proliferation, migration, and invasion. However, the role of ALX4 in hepatocellular carcinoma (HCC) remains largely unclear. Therefore, in this study we investigated the effects of ALX4 on HCC. The study results indicated that the expression of ALX4 was downregulated in HCC tissues and cell lines. Furthermore, we demonstrated that overexpression of ALX4 inhibited the proliferation, invasion, and epithelial–mesenchymal transition (EMT) in HCC cells. We also found that ALX4 had an inhibitory effect on the sonic hedgehog More >

  • Open Access

    ARTICLE

    UNSTEADY MHD THREE-DIMENSIONAL CASSON NANOFLUID FLOW OVER A POROUS LINEAR STRETCHING SHEET WITH SLIP CONDITION

    I.S. Oyelakina,† , S. Mondala,* , P. Sibandaa

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-9, 2017, DOI:10.5098/hmt.8.37

    Abstract In this paper we study the effects of thermal radiation, heat and mass transfer on the unsteady magnetohydrodynamic(MHD) flow of a three dimensional Casson nanofluid. The flow is subject to partial slip and convective conditions. The traditional model which includes the effects of Brownian motion and thermophoresis is revised so that the nanofluid particle volume fraction on the boundary is not actively controlled. In this respect the problem is more realistic. The dimensionless governing equations were solved using the spectral quasi-linearisation method. This work aims to fill the gap in existing literature by showing the More >

  • Open Access

    ARTICLE

    3D NUMERICAL INVESTIGATION ON LAMINAR FORCED CONVECTION AND HEAT TRANSFER IN A CIRCULAR TUBE INSERTED WITH RIGHT TRIANGULAR WAVY SURFACES

    Withada Jedsadaratanachaia, Amnart Boonloib,*

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-8, 2017, DOI:10.5098/hmt.8.35

    Abstract Numerical investigations on flow and heat transfer characteristics in a circular tube heat exchanger inserted with right triangular wavy surfaces are reported. The configurations of the wavy surfaces; incline and V-shape, are studied with flow attack angles of 30o, 45o and 60o for the Reynolds numbers, Re = 100 – 2000. The numerical results are compared with the smooth circular tube. The mechanisms on flow and heat transfer in the tube heat exchanger with the wavy surface are presented. As the results, the wavy surface can generate the vortex flow and impinging flow through the test… More >

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