Maha Kammoun-Krichen1, Noura Bougacha-Elleuch1, Kaouthar Makni1, Maha Rebai3, Sylvie Peraldi-Roux2, Ahmed Rebai3, Mouna Mnif4, Mohamed Abid4, Joumaa Jouida5, Hammadi Ayadi1
European Cytokine Network, Vol.18, No.4, pp. 196-200, 2007, DOI:10.1684/ecn.2007.0104
Abstract Autoimmune thyroid diseases (AITDs), including Graves’ disease (GD) and autoimmune hypothy-roidism
(AH), are inherited as complex traits. Among the genes contributing to AITDs susceptibility are genes of
the IL-1 family. IL-1 regulates T and B lymphocyte maturation, including the induction of several cytokines and
cytokine receptors. Therefore, disturbances of this balance may not only play a role in inflammation but also in
the pathogenesis of autoimmunity. In order to investigate genetic association of IL-1 gene polymorphisms with
AITDs, we performed both a familial study in a large Tunisian pedigree with high prevalence of AITDs
(64… More >