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  • Open Access

    REVIEW

    Future perspectives on cell therapy for autism spectrum disorder

    MAKOTO NABETANI1,*, TAKEO MUKAI2

    BIOCELL, Vol.46, No.4, pp. 873-879, 2022, DOI:10.32604/biocell.2022.018218 - 15 December 2021

    Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social communication, abnormal to absent verbal communication, the presence of repetitive stereotypic verbal and non-verbal behaviors and restricted interests, with onset early in life. We showed cognitive and behavioral characteristics of ASD by impairment of communication, cognition, perception, motor skills, executive function, theory of mind and emotion control. Recently, pathogenesis of immune pathology in the brains of individuals with ASD has been focused. New therapeutic approaches in the viewpoints of immune modulation and microglial function are logical for novel treatments for individuals More >

  • Open Access

    REVIEW

    Mesenchymal stem cells: As a multi-target cell therapy for clearing β-amyloid deposition in Alzheimer’s disease

    RUXIN ZHANG1, CHENGGANG LI2, RUOCHEN DU1, YITONG YUAN1, BICHUN ZHAO1, YUJUAN ZHANG1, CHUNFANG WANG1,*

    BIOCELL, Vol.46, No.3, pp. 583-592, 2022, DOI:10.32604/biocell.2022.017248 - 18 November 2021

    Abstract Extracellular β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) are the pathological hallmarks of Alzheimer’s disease (AD). Studies have shown that aggregates of extracellular Aβ can induce neuroinflammation mediated neurotoxic signaling through microglial activation and release of pro-inflammatory factors. Thus, modulation of Aβ might be a potential therapeutic strategy for modifying disease progression. Recently, a large number of reports have confirmed the beneficial effects of mesenchymal stem cells (MSCs) on AD. It is believed to reduce neuroinflammation, reduce Aβ amyloid deposits and NFTs, increase acetylcholine levels, promote neurogenesis, reduce neuronal damage, and improve working memory and More >

  • Open Access

    VIEWPOINT

    Nanotherapeutics approaches to improve the efficacy of CAR-T cells in solid tumors

    FRANCESCO MAININI*

    BIOCELL, Vol.45, No.5, pp. 1171-1173, 2021, DOI:10.32604/biocell.2021.017399 - 12 July 2021

    Abstract Adoptive cell therapy and Immune Checkpoint Blockade Inhibitors have recently revolutionized the field of oncology. However, these types of immunotherapeutic approaches have limited success in treating solid tumors. In particular, chimeric antigen receptor (CAR)-T cells efficacy is hampered by immunosuppressive signals in the tumor microenvironment (TME) and by a limited infiltration of re-infused T cells to the tumor site. The field of nanobiotechnology applied to oncology is also rapidly expanding. Nanoparticles-based delivery systems can be employed to modulate the activity of immune cells present in the TME enhancing the efficacy of CAR-T cells. Interestingly, nano-backpacks More >

  • Open Access

    ARTICLE

    Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration

    JIGANG LEI1,#, ZHENYAO XU2,#, SUKE LI1, MENG LI1, ZHIKAI WANG3, PING LI1, JING WANG1, YINGLU CHEN1, XIAOLE SONG1, CHENGJIE REN1, MEIPING SHEN1, CHENGXIANG DAI1,*

    BIOCELL, Vol.45, No.3, pp. 537-546, 2021, DOI:10.32604/biocell.2021.014569 - 03 March 2021

    Abstract Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3% around the world, involving increased keratinocyte proliferation. Indeed, Th17 cells and IL-17 play critical roles in the pathogenesis of psoriasis. The monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human psoriasis. However, there are still some patients that have no response to these treatments. Some patients have even serious side-effects which may affect their life. Mesenchymal stem cells have the ability of immunosuppressive and anti-inflammatory effects, which may be an alternative therapy with more safety and efficacy… More >

  • Open Access

    REVIEW

    Adipose-derived mesenchymal stem/stromal cells: from the lab bench to the basic concepts for clinical translation

    Yesica Romina FRONTINI-LÓPEZ1, Aldana Daniela GOJANOVICH1, Diego MASONE1,2, Diego Martín BUSTOS1,3, Marina UHART1

    BIOCELL, Vol.42, No.3, pp. 67-78, 2018, DOI:10.32604/biocell.2018.07013

    Abstract In the last years, much work has shown that the most effective repair system of the body is represented by stem cells, which are defined as undifferentiated precursors that own unlimited or prolonged self-renewal ability, which also have the potential to transform themselves into various cell types through differentiation.All tissues that form the body contain many different types of somatic cells, along with stem cells that are called ‘mesenchymal stem (or stromal) cells’ (MSC). In certain circumstances, some of these MSC migrate to injured tissues to replace dead cells or to undergo differentiation to repair… More >

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