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  • Open Access

    ARTICLE

    An association study of inflammatory cytokine gene polymorphisms in Fabry disease

    Ilona Bányász1, Géza Bokodi1, Barna Vásárhelyi2, András Treszl1, László Derzbach1, András Szabó1, Tivadar Tulassay1,2,3, Ádám Vannay3

    European Cytokine Network, Vol.17, No.4, pp. 271-275, 2006, DOI:10.1684/ecn.2006.0043

    Abstract Background. Fabry disease is an X-linked disorder associated with early-onset stroke, cardiomyopathy, and progression to end-stage renal failure. Correlations between inflammatory cytokines have been shown in other lysosomal storage diseases. The aim of the study was to evaluate functional gene polymorphisms of key pro- and anti-inflammatory cytokines and to correlate them to a clinical score to assess the potential role of inflammation in Fabry disease. Design. Genotyping for IL-10[819C/T; -592C/A]; IL-1β[+3954C/T; –511C/T]; IL-1α[-889C/T]; and TNF-α[-308G/A] was performed in 76 patients and correlated with MSSI sub-scores and with enzyme (alpha-galactosidase A) levels. Fifty, normal, age- and… More >

  • Open Access

    RESIDENT’S CORNER

    Parameters affecting urologic complications after major joint replacement surgery

    Jason P. Izard1, Richard D. Sowery1, Melanie T. Jaeger2, D. Robert Siemens1

    Canadian Journal of Urology, Vol.13, No.3, pp. 3158-3163, 2006

    Abstract Introduction and objectives: Peri-operative bladder management after major arthroplasty procedures remains controversial. The purpose of this study was to assess the risk of urological complications in those patients undergoing hip or knee joint replacement. As well, we identified those factors that may affect the likelihood of developing complications.
    Methods: Two hundred and twenty-one consecutive patients receiving a total knee or hip arthroplasty were reviewed. The outcomes measured were prolonged urinary retention, as well as urinary tract infections and the development of a septic prosthesis. Statistical significance of any predisposing factors identified was determined using a two-tailed Fisher… More >

  • Open Access

    RESIDENT’S CORNER

    Subcutaneous reservoir placement during penile prosthesis implantation

    M. C. Smaldone, G. M. Cannon Jr, R. M. Benoit

    Canadian Journal of Urology, Vol.13, No.6, pp. 3351-3352, 2006

    Abstract Currently, the prosthesis of choice for patients undergoing penile prosthesis surgery is a three piece inflatable device, as this provides optimal inflation and deflation when compared to a one or two piece prosthesis. However, prior pelvic surgery or radiation therapy can obliterate the retropubic space and make placement of the reservoir required for a three piece prosthesis difficult. We report a novel location for reservoir placement in a man who had undergone multiple pelvic surgeries after suffering a severe pelvic crush injury. More >

  • Open Access

    ARTICLE

    The Numerical Analysis of Reinforced Concrete Beams Using Embedded Discontinuities

    R. Costa1, J. Alfaiate2

    Structural Durability & Health Monitoring, Vol.2, No.1, pp. 11-18, 2006, DOI:10.3970/sdhm.2006.002.011

    Abstract In this paper a numerical simulation is performed on the behaviour of reinforced concrete beams, submitted to initial damage, subsequently strengthened with external steel plates bonded with epoxy. Modelling these structures requires the characterization of the behaviour of different materials as well as the connection between them. Fracture is modelled within the scope of a discrete crack approach, using a formulation in which strong discontinuities are embedded in the finite elements. In this approach, the displacement field is truly discontinuous and the jumps are non-homogeneous within each parent element [Alfaiate, Wells and Sluys (2000)]. More >

  • Open Access

    ARTICLE

    A New Method of Controlling Shrinkage Cracking in Repaired Concrete Structures Using an Interface Layer of Carbon Fiber Reinforced Cement Mortar

    Shen Yubin1, Xie Huicai1,2, Den Wei1

    CMC-Computers, Materials & Continua, Vol.3, No.2, pp. 49-54, 2006, DOI:10.3970/cmc.2006.003.049

    Abstract Bonding an overlay of new concrete onto the damaged concrete is a usual repair method. Because of the different shrinkage rate of the new and old concrete, restrained shrinkage cracks will appear in the new concrete. The cracks will reduce durability and strength of the repaired structure. A new repair method using an interface layer of carbon fiber reinforced cement mortar between new and old concrete was developed in this paper. The new method was found to be very effective in reducing shrinkage cracking of repaired beams and slabs. Comparing with normal repaired beams, the More >

  • Open Access

    ARTICLE

    Applications of DTALE: Damage Tolerance Analysis and Life Enhancement [3-D Non-plannar Fatigue Crack Growth]

    S. N. Atluri1

    Structural Durability & Health Monitoring, Vol.1, No.1, pp. 1-20, 2005, DOI:10.3970/sdhm.2005.001.001

    Abstract The solution of three-dimensional cracks (arbitrary surfaces of discontinuity) in solids and structures is considered. The BEM, developed based on the symmetric Galerkin BIEs, is used for obtaining the fracture solutions at the arbitrary crack-front. The finite element method is used to model the uncracked global (built-up) structure for obtaining the stresses in an otherwise uncracked body. The solution for the cracked structural component is obtained in an iteration procedure, which alternates between FEM solution for the uncracked body, and the SGBEM solution for the crack in the local finite-sized subdomain. In addition, some crack… More >

  • Open Access

    ARTICLE

    Interfacial Strength of Cement Lines in Human Cortical Bone

    X. Neil Dong1,2, Xiaohui Zhang1, X. Edward Guo1

    Molecular & Cellular Biomechanics, Vol.2, No.2, pp. 63-68, 2005, DOI:10.3970/mcb.2005.002.063

    Abstract In human cortical bone, cement lines (or reversal lines) separate osteons from the interstitial bone tissue, which consists of remnants of primary lamellar bone or fragments of remodeled osteons. There have been experimental evidences of the cement line involvement in the failure process of bone such as fatigue and damage. However, there are almost no experimental data on interfacial properties of cement lines in human cortical bone. The objective of this study is to design and assemble a precision and computer controlled osteon pushout microtesting system, and to experimentally determine the interfacial strength of cement… More >

  • Open Access

    ARTICLE

    Coupled Analysis of Independently Modeled Finite Element Substructures by Moving Least Squares Displacement Welding Technique

    Jin Yeon Cho1, Jae Mo An2, You Me Song1, Seungsoo Lee1, Dong Whan Choi1

    CMES-Computer Modeling in Engineering & Sciences, Vol.9, No.1, pp. 1-18, 2005, DOI:10.3970/cmes.2005.009.001

    Abstract A displacement welding technique is proposed to carry out coupled analysis of the integrated whole model which consists of independently modeled finite element substructures. In the proposed method, the incompatible displacement fields in the interfaces of independently modeled substructures are directly welded together through a blended function that is newly defined in the transient region of mismatching interface. To construct the blended function, the moving least squares function, which does not require well-defined nodal connectivity, is utilized along with the original finite element shape function. The meshless character of the moving least squares function makes More >

  • Open Access

    ARTICLE

    Reinforced 2d Domain Analysis Using BEM and Regularized BEM/FEM Combination

    Alexandre S. Botta1, Wilson S. Venturini2

    CMES-Computer Modeling in Engineering & Sciences, Vol.8, No.1, pp. 15-28, 2005, DOI:10.3970/cmes.2005.008.015

    Abstract In this work a regularized boundary-finite element combination is proposed to analyse 2D elastostatic solids reinforced by fibres. The boundary element is adopted to model the matrix behaviour, while finite elements model the embedded fibres. The debonding effects caused by the adherence loss between the two materials are also considered. A three-degree polynomial is adopted to approach the displacement field along the fibre elements, while linear approximations are used to represent the bonding forces between fibres and the matrix. The non-linear debonding model is governed by a loading function written in terms of the contact More >

  • Open Access

    EDITORIAL

    Preface: International Workshop on "Development and Advancement of Computational Mechanics'', April 22-23, 2005

    Hiroshi Okada1

    CMES-Computer Modeling in Engineering & Sciences, Vol.10, No.3, pp. 185-186, 2005, DOI:10.3970/cmes.2005.010.185

    Abstract This article has no abstract. More >

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