WAN AZANI MUSTAFA^1,2,*, AFIQAH HALIM², MOHD WAFI NASRUDIN², KHAIRUL SHAKIR AB RAHMAN³

BIOCELL, Vol.46, No.2, pp. 367-381, 2022, DOI:10.32604/biocell.2022.016814

Abstract Cervix cancer is one of Malaysia’s most significant cancers for women (around 12.9%, with an age-standardised incidence rate of 19.7 per 100,000). It was higher than other Asian, West, and even worldwide nations. The National Strategic Plan for Cancer Control Program 2016–2020 (Health Ministry) was presented to minimize cancer and mortality. The high incidence of cervical cancer in Malaysia is mainly due to women’s insufficient knowledge about its prevention and importance. Compared with traditional literature reviews, the systemic analysis provides many advantages. A clearer review process, a more prominent field of study, and essential priorities that can manage research bias… More >

Mohamed Ibrahim Waly¹, Mohamed Yacin Sikkandar¹, Mohamed Abdelkader Aboamer¹, Seifedine Kadry², Orawit Thinnukool^3,*

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 3295-3309, 2022, DOI:10.32604/cmc.2022.020713

Abstract Biomedical imaging is an effective way of examining the internal organ of the human body and its diseases. An important kind of biomedical image is Pap smear image that is widely employed for cervical cancer diagnosis. Cervical cancer is a vital reason for increased women’s mortality rate. Proper screening of pap smear images is essential to assist the earlier identification and diagnostic process of cervical cancer. Computer-aided systems for cancerous cell detection need to be developed using deep learning (DL) approaches. This study introduces an intelligent deep convolutional neural network for cervical cancer detection and classification (IDCNN-CDC) model using biomedical… More >

Ali Raza¹, Muhammad Rafiq², Dalal Alrowaili³, Nauman Ahmed⁴, Ilyas Khan^5,*, Kottakkaran Sooppy Nisar⁶, Muhammad Mohsin⁷

CMC-Computers, Materials & Continua, Vol.70, No.1, pp. 1649-1666, 2022, DOI:10.32604/cmc.2022.019148

Abstract Nonlinear modelling has a significant role in different disciplines of sciences such as behavioral, social, physical and biological sciences. The structural properties are also needed for such types of disciplines, as dynamical consistency, positivity and boundedness are the major requirements of the models in these fields. One more thing, this type of nonlinear model has no explicit solutions. For the sake of comparison its computation will be done by using different computational techniques. Regrettably, the aforementioned structural properties have not been restored in the existing computational techniques in literature. Therefore, the construction of structural preserving computational techniques are needed. The… More >

Madhumitha Kedhari Sundaram¹, Abdulmajeed G. Almutary², Shafiul Haque³, Faheem SM¹, Arif Hussain^1,*

Oncologie, Vol.23, No.2, pp. 269-277, 2021, DOI:10.32604/Oncologie.2021.016002

Abstract Cervical cancer is the neoplasm of the uterine cervix in women, which is highly preventable. With the advent of vaccination against HPV infection, a gradual decline in the incidence of cervical cancer cases has been observed in developing countries. The developing nations bear the brunt of cervical cancer incidence due to low acceptance of vaccination. This survey-based study was designed to assess the awareness and opinions of female university students regarding human papilloma virus, vaccination and cervical cancer. A survey questionnaire was distributed among female expatriate students (18 to 26 years of age) of a private university. The survey sought… More >

Kalaivani Muniandy¹, Zuhaida Asra Ahmad^1,4, Sylvia Annabel Dass¹, Shaharum Shamsuddin², Nethia Mohana Kumaran³, Venugopal Balakrishnan^1,*

Oncologie, Vol.23, No.2, pp. 279-291, 2021, DOI:10.32604/Oncologie.2021.015969

Abstract Spheroids are generally self-assembled cells with the ability to generate their extracellular matrix, including the complex cell-matrix and the cell-cell interactions that resemble the functional characteristics of the corresponding tissue in vivo. The study aimed to develop a three-dimensional (3D) spheroid system for the cervical cancer cell lines, HeLa (HPV18), CaSki (HPV16), SiHa (HPV16), C33A (non-HPV), HT3 (non-HPV) as well as to identify its biological activity in the extracellular form. For the formation of the cervical cancer spheroids, the liquid overlay approach was applied, followed by embedding to the bovine collagen I matrix. Spheroid formation using the liquid overlay approach… More >

Afiqah Halim¹, Wan Azani Mustafa^1,2,*, Wan Khairunizam Wan Ahmad¹, Hasliza A. Rahim², Hamzah Sakeran³

Oncologie, Vol.23, No.1, pp. 73-88, 2021, DOI:10.32604/Oncologie.2021.015154

Abstract Cervical cancer is a cell disease in the cervix that develops out of control in the female body. The cervix links the vagina (birth canal) with the upper section of the uterus, which can only be found in the female body. This is the second leading cause of death among women around the world. However, cervical cancer is currently one of the most preventable cancers if early detection is identified. The effect of unidentified cancer may increase the risk of death when the cell disease spreads to other parts of the female anatomy (metastasize). The Papanicolaou test is a cervical… More >

WENXI GAO^1,2,#, QIANQIAN MA^3,#, CHENYU TANG^2,#, YUELI ZHAN⁴, YINONG DUAN², HUIHUA NI^5,*, YUNZHAO XU^5,6,*

BIOCELL, Vol.44, No.4, pp. 597-605, 2020, DOI:10.32604/biocell.2020.011328

Abstract Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. Functional enrichment analysis, pathway enrichment analysis, and PPI network… More >

Yanhong ZHEN¹, Li HAN², Kailai CAI¹, Lijun HUO¹, Hasan RIAZ¹, Canjie WU¹, Aixin LIANG¹ , Lei SANG¹, Liguo YANG^{1 *}

BIOCELL, Vol.38, No.1, pp. 17-24, 2014, DOI:10.32604/biocell.2014.38.017

Abstract Inhibins play important roles in the reproductive system. To evaluate whether inhibin α (1-32) fusion protein plays a role in cervical cancer growth, the plasmid pVAX-inhα was constructed and its effect on proliferation and apoptosis of the human cervical cancer cell line (Hela) was checked by flow cytometry and real-time PCR. The expression and localization of inhibin α protein were detected by RT-PCR and confocal microscopy which showed that inhibin α protein was expressed and localized in the nucleus of Hela cells. Over expression of inhibin α gene significantly induced cell apoptosis and ceased S phase of cell cycle. Furthermore,… More >

Tong MA^{1, §}, Fafen WANG^{2, §}, Xiaohui WANG¹

BIOCELL, Vol.43, No.3, pp. 191-198, 2019, DOI:10.32604/biocell.2019.06989

Abstract Cervical cancer (CC), has been identified as one of the most frequent malignant tumors all over the world, with high mortality in females. A growing number of investigations have confirmed that long noncoding RNAs (lncRNAs) play a crucial role in the progression of multiple cancers. Nonetheless, the biological function and regulatory mechanism of LINC01772 in CC haven’t been explored so far. In this study, LINC01772 expression was found to be upregulated in tissues and cells of CC. Knocking down LINC01772 suppressed CC cell proliferation, migration and epithelial-mesenchymal transition (EMT) process. Through molecular mechanism assays, LINC01772 was verified to be bound… More >