Seth A. Cohen¹, Ryan P. Kopp¹, Kerrin L. Palazzi¹, Michael A. Liss¹, Reza Mehrazin², Jason Woo¹, Hak J. Lee¹, Ramzi Jabaji¹, Kyle Gillis¹, Song Wang¹, Robert W. Wake², Anthony L. Patterson², Ithaar H. Derweesh¹

Canadian Journal of Urology, Vol.22, No.6, pp. 8085-8092, 2015

Abstract Introduction: To investigate the association of C-reactive protein (CRP), a marker of systemic inflammation, with renal functional decline in patients undergoing partial nephrectomy (PN) for renal mass.
Materials and methods: Retrospective study of patients who underwent PN between February 2006-March 2011, with ≥6 months follow-up. Data was analyzed between two groups: CRP increase ≥0.5 mg/L from 6 months postoperative ("CRP rise," CRPR) versus no CRP increase ≥0.5 ("CRP stable," CRPS). Primary outcome was change in estimated glomerular filtration rate (ΔeGFR, mL/min/1.73 m²), with de novo postoperative stage III chronic kidney disease (stage III-CKD, eGFR <60 mL/min/1.73 m²)… More >

Seth A. Cohen¹, Ryan P. Kopp¹, Kerrin L. Palazzi¹, Michael A. Liss¹, Reza Mehrazin², Jason Woo¹, Hak J. Lee¹, Ramzi Jabaji¹, Kyle Gillis¹, Song Wang¹, Robert W. Wake², Anthony L. Patterson², Ithaar H. Derweesh¹

Canadian Journal of Urology, Vol.22, No.6, pp. 8085-8092, 2015

Abstract Introduction: To investigate association of C-reactive protein (CRP), a marker of systemic inflammation, with renal functional decline in patients undergoing partial nephrectomy (PN) for renal mass.
Materials and methods: Retrospective study of patients who underwent PN between February 2006-March 2011, with ≥6 months follow up. Data was analyzed between two groups: CRP increase ≥0.5 mg/L from 6 months postoperative ("CRP rise," CRPR), versus no CRP increase ≥0.5 ("CRP stable," CRPS). Primary outcome was change in estimated glomerular filtration rate (ΔeGFR, mL/min/1.73 m²), with de novo postoperative stage III chronic kidney disease (stage III-CKD, eGFR <60 mL/min/1.73 m²)… More >

Ramzi Jabaji¹, Kerrin L. Palazzi¹, Reza Mehrazin², Seth A. Cohen¹, James H. Masterson³, Jason R. Woo¹, Hak Lee^1,4, Michael A. Liss^1,4, Ryan P. Kopp¹, Song Wang¹, Sean P. Stroup³, Anthony L. Patterson², James O. L’Esperance³, Ithaar H. Derweesh^1,4

Canadian Journal of Urology, Vol.21, No.1, pp. 7126-7133, 2014

Abstract Introduction: Renal functional decline after partial nephrectomy (PN) may be related to a variety of non-modifiable and modifiable factors, including ischemia time (IT) and modality. We sought to determine the impact of these factors on renal functional degeneration after PN.
Materials and methods: Multicenter retrospective analysis (n = 347) was performed, identifying patients who underwent open PN using warm, cold, and non-ischemic techniques. Primary outcome was development of de novo chronic kidney disease (CKD), (estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m²), at 1 year follow-up. Univariate and multivariable analysis (MVA) were performed examining factors associated… More >

Fiona Mei Wen Wu¹, Melissa Hui Wen Tay¹, Zhaojin Chen², Bee Choo Tai^3,4, Lincoln Guan Lim Tan¹, Lata Raman¹, Ho Yee Tiong¹

Canadian Journal of Urology, Vol.21, No.4, pp. 7351-7357, 2014

Abstract Introduction: To compare baseline renal function and identify predictive factors in patients undergoing radical nephrectomy (RN) or donor nephrectomy (DN) and their risk of subsequent chronic kidney disease (CKD) after surgery.
Materials and methods: A retrospective review of patients with no baseline CKD undergoing RN (n = 88) and DN (n = 58) from 2000 to 2008 was performed. Baseline and postoperative renal function (eGFR) was determined using the Modification of Diet in Renal Disease (MDRD) formula. CKD was defined as eGFR < 60 mL/min/1.73 m² according to the National Kidney Foundation guidelines.
Results: Before surgery, patients undergoing… More >

Tin C. Ngo¹, Michael P. Hurley², Alan E. Thong¹, Seung Hyun Jeon³, John T. Leppert^1,4, Benjamin I. Chung¹

Canadian Journal of Urology, Vol.20, No.6, pp. 7035-7041, 2013

Abstract Introduction: To identify factors associated with the development of chronic kidney disease (CKD) after nephrectomy and to create a clinical model to predict CKD after nephrectomy for kidney cancer for clinical use.
Materials and methods: We identified 144 patients who had normal renal function (eGFR > 60) prior to undergoing nephrectomy for kidney cancer. Selected cases occurred between 2007 and 2010 and had at least 30 days follow up. Sixty-six percent (n = 95) underwent radical nephrectomy and 62.5% (n = 90) developed CKD (stage 3 or higher) postoperatively. We used univariable analysis to screen for predictors… More >

Majid Mahmoodi^1,2, Asghar Aghamohammadi^3,4, Nima Rezaei^3,4, Mahboob Lessan-Pezeshki⁵, Gholamreza Pourmand⁶, Mohammad-Ali Mohagheghi¹, Sina Abdollahzade⁴, Alireza Mousavi-Jarrahi¹

European Cytokine Network, Vol.20, No.2, pp. 69-74, 2009, DOI:10.1684/ecn.2009.0153

Abstract Patients with chronic kidney disease (CKD) or on dialysis are at greater risk of infection, which might be due to a defective immune function. While there are controversial reports on efficacy of vaccination in this group of patients, the aim of this study was to evaluate the antibody response to pneumococcal capsular polysaccharide vaccine (PPV23) in CKD patients. Sixty-six patients with CKD and 40 healthy individuals were vaccinated with PPV23. Blood samples were taken before and four weeks after vaccination. Specific antibodies against whole pneumococcal antigens were measured using an enzyme-linked immunosorbent assay (ELISA) technique.… More >