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  • Open Access


    Two Stage Classification with CNN for Colorectal Cancer Detection

    Pallabi Sharma1,*, Kangkana Bora2, Kunio Kasugai3, Bunil Kumar Balabantaray1

    Oncologie, Vol.22, No.3, pp. 129-145, 2020, DOI:10.32604/oncologie.2020.013870

    Abstract In this paper, we address a current problem in medical image processing, the detection of colorectal cancer from colonoscopy videos. According to worldwide cancer statistics, colorectal cancer is one of the most common cancers. The process of screening and the removal of pre-cancerous cells from the large intestine is a crucial task to date. The traditional manual process is dependent on the expertise of the medical practitioner. In this paper, a two-stage classification is proposed to detect colorectal cancer. In the first stage, frames of colonoscopy video are extracted and are rated as significant if More >

  • Open Access


    A Polyp Detection Method Based on FBnet

    Jingjing Wan1, Taiyue Chen2, *, Bolun Chen2, 3, *, Yongtao Yu2, Yiyun Sheng2, Xinggang Ma1

    CMC-Computers, Materials & Continua, Vol.63, No.3, pp. 1263-1272, 2020, DOI:10.32604/cmc.2020.010098

    Abstract The incidence of colorectal cancer (CRC) in China has increased in recent years. The mortality rate of CRC has become one of the highest among all cancers; CRC increasingly affects the health and quality of people’s lives. However, due to the insufficiency of medical resources in China, the workload on medical doctors has further increased. In the past few decades, the adult CRC mortality and morbidity rate dropped sharply, mainly because of CRC screening and removal of adenomatous polyps. However, due to the differences in polyp itself and the skills of endoscopists, the detection rate… More >

  • Open Access


    Interaction of IL-22/IL-22R1 promotes cell proliferation and suppresses apoptosis of colorectal cancer via phosphorylation of STAT3

    Xiaoning Qin1, Liqing Yuan2, Hongxun Ruan1, Lin Lin1

    BIOCELL, Vol.43, No.2, pp. 89-98, 2019, DOI:10.32604/biocell.2019.06352

    Abstract Interleukin-22 (IL-22) is a member of IL-10 cytokine family which is expressed in activated T cells predominantly and in activated natural killer cells at lower levels. Previous studies have demonstrated the link between elevated levels of IL-22 and disease severity of psoriasis, Crohn’s disease, rheumatoid arthritis and interstitial lung diseases. However, the function of IL-22 in the development and progression of colorectal cancer (CRC) remains elusive. In this study, we first evaluated the IL-22/IL-22R1 level in CRC patients, and found that tumor tissues have more active expression of IL-22 and IL-22R1 than normal tissues,… More >

  • Open Access


    The expressional level of tankyrase-1 gene and its regulation in colorectal cancer in a Saudi population

    Hala Abdulaziz M ALWARTHAN1, Mohammad Saud AL ANAZI1, Narasimha R. PARINE1, Ramesa Shafi BHAT1,*, Ghadah ALAMRO1, Ftoon ALJARBOU1, Sooad K AL-DAIHAN1

    BIOCELL, Vol.43, No.2, pp. 51-58, 2019, DOI:10.32604/biocell.2019.07019

    Abstract Tankyrase1 plays an essential role in cancer progression by regulating telomere length. The study aimed to determine expression of TNKS1 and its regulation in colorectal cancer (CRC) in 20 samples from Saudi patients. mRNA expression of TNKS1 in CRC and paired normal tissues was measured by qRT-PCR. Epigenetic modification of TNKS1 promoter was determined by methylation-specific PCR while somatic mutation was analyzed by Sanger sequencing in exon 10 of the gene. All cancerous and normal tissues expressed TNKS1, but level of expression in CRC tissues was significantly associated with tumor stage though no other parameters; age, gender,… More >

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