Huiqing Lv*, Zhongmin Zhang†, Yaoxia Wang†, Chenglin Li†, Weihong Gong†, Xin Wang†
Oncology Research, Vol.23, No.6, pp. 283-290, 2015, DOI:10.3727/096504016X14562725373833
Abstract Colorectal cancer (CRC) is the third most common malignancy with high mortality around the world. However,
the biological mechanism of CRC carcinogenesis is not completely known. In the present study, we determined
the role of miR-92a in the regulation of CRC cell motility. Expression of miR-92a is aberrantly upregulated
in human CRC tissues and cultured cells, as shown by RT-PCR analysis. The effects of miR-92a on the proliferation and migration of human CRC SW620 and LoVo cells were measured by CCK-8 and Transwell assay,
respectively. Results showed that the proliferation and migration capacity of both… More >
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