Feng Shuai^*, Bo Wang^†, Shuxiao Dong^‡

Oncology Research, Vol.28, No.9, pp. 975-975, 2020, DOI:10.3727/096504021X16297182567090

Abstract This article has no abstract. More >

Wei Song^*, Jia-Zhuan Mei^†, Mingzhi Zhang^‡

Oncology Research, Vol.28, No.9, pp. 971-972, 2020, DOI:10.3727/096504022X16414984936791

Abstract Accumulating evidence has indicated that long noncoding RNA (lncRNA) PlncRNA-1 plays an important regulatory role in cancers. However, the expression and biological functions of PlncRNA-1 in colorectal cancer (CRC) are still unclear. In the present study, we determined the expression of PlncRNA-1 in CRC and explored the function of PlncRNA-1 on CRC cell progression. The results showed that PlncRNA-1 was significantly increased in CRC tissues and cell lines; high PlncRNA-1 expression was associated with depth of invasion, lymph node metastasis, and TNM stage of CRC patients. Kaplan–Meier curve analysis showed that patients with high PlncRNA-1 More >

Tsung-Kun Chang^*†, Tzu-Chieh Yin^‡§, Wei-Chih Su^*†, Hsiang-Lin Tsai^*¶, Ching-Wen Huang^*¶, Yen-Cheng Chen^*, Ching-Chun Li^*, Po-Jung Chen^*, Cheng-Jen Ma^*§, Kuo-Hsiang Chuang^#, Tian-Lu Cheng^**, Jaw-Yuan Wang^{*†¶††‡‡§§}

Oncology Research, Vol.28, No.7-8, pp. 801-809, 2020, DOI:10.3727/096504021X16218531628569

Abstract Irinotecan, a topoisomerase inhibitor, is a common cytotoxic agent prescribed for metastatic colorectal cancer (mCRC) patients. Diarrhea is the most common adverse event (AE). The underlying mechanism of irinotecaninduced diarrhea is intestinal mucosal damage caused by SN-38 (active metabolite of irinotecan) hydrolyzed from SN-38G (inactive metabolite) by bacterial -glucuronidase ( G). According to an animal study, silymarin reduces the activity of bacterial G without impairing antitumor efficacy. We conducted a prospective openlabel pilot study to evaluate the effect of silymarin as supplementation in reducing toxicities of mCRC patients undergoing irinotecan-based chemotherapy. We enrolled and randomized More >

Ching-Wen Huang^*, Cheng-Jen Ma^*†, Wei-Chih Su^*, Yi-Ting Chen^‡§, Hsiang-Lin Tsai^*¶, Yung-Sung Yeh^*#, Tsung-Kun Chang^*, Wen-Hung Hsu^**††, Fang-Jung Yu^**††, Jaw-Yuan Wang^{*¶‡‡§§¶¶##}

Oncology Research, Vol.28, No.7-8, pp. 701-714, 2020, DOI:10.3727/096504020X15986099915822

Abstract This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen adjuvant chemotherapy. The clinicopathological features and effects of metronomic maintenance therapy with oral capecitabine (daily dose of 850 mg/m2 , twice daily, on days 1–14 every 3 weeks for 6 months) on survival according to treatment group and EGFR expression were analyzed. By conducting an in vitro cell line study… More >

Li Bao¹, Xiaowei Tian², Jing Zhang³, Li Chen⁴, Kui Gao^5,*

Oncologie, Vol.22, No.3, pp. 167-178, 2020, DOI:10.32604/oncologie.2020.012495

Abstract Ulinastatin combined with dexmedetomidine can improve postoperative cognitive function and central nerve specific protein (S-100β) level in elderly colorectal cancer (CC) patients after laparoscopic. Altogether 178 elderly patients who underwent laparoscopic colorectal cancer surgery in our hospital from February 2018 to August 2019 were selected and divided into two groups according to the treatment methods. Those anesthetized by dexmedetomidine were regarded as the routine group (RG, 83 cases), and those anesthetized by ulinastatin and dexmedetomidine were considered as the combined group (CG, 95 cases). The operation conditions of the two groups, the pain scores (VAS)… More >

Pallabi Sharma^1,*, Kangkana Bora², Kunio Kasugai³, Bunil Kumar Balabantaray¹

Oncologie, Vol.22, No.3, pp. 129-145, 2020, DOI:10.32604/oncologie.2020.013870

Abstract In this paper, we address a current problem in medical image processing, the detection of colorectal cancer from colonoscopy videos. According to worldwide cancer statistics, colorectal cancer is one of the most common cancers. The process of screening and the removal of pre-cancerous cells from the large intestine is a crucial task to date. The traditional manual process is dependent on the expertise of the medical practitioner. In this paper, a two-stage classification is proposed to detect colorectal cancer. In the first stage, frames of colonoscopy video are extracted and are rated as significant if More >

Jingjing Wan¹, Taiyue Chen^{2, *}, Bolun Chen^{2, 3, *}, Yongtao Yu², Yiyun Sheng², Xinggang Ma¹

CMC-Computers, Materials & Continua, Vol.63, No.3, pp. 1263-1272, 2020, DOI:10.32604/cmc.2020.010098 - 30 April 2020

Abstract The incidence of colorectal cancer (CRC) in China has increased in recent years. The mortality rate of CRC has become one of the highest among all cancers; CRC increasingly affects the health and quality of people’s lives. However, due to the insufficiency of medical resources in China, the workload on medical doctors has further increased. In the past few decades, the adult CRC mortality and morbidity rate dropped sharply, mainly because of CRC screening and removal of adenomatous polyps. However, due to the differences in polyp itself and the skills of endoscopists, the detection rate… More >

Xingxiang Liu^*†, Lin Cui^†, Dong Hua^*‡

Oncology Research, Vol.27, No.1, pp. 99-106, 2019, DOI:10.3727/096504018X15195193936573

Abstract We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST) in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST, or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. lncRNA XIST was upregulated in CRC tissues. Compared with HT29 cells that had low metastatic potential, XIST was… More >

Hai Liu^*, Xuanxuan Wang^*, Aihua Huang^†, Huaping Gao^‡, Yikan Sun^§, Tingting Jiang^*, Liming Shi^*, Xianjie Wu^¶, Qinghua Dong^#, Xiaonan Sun^*

Oncology Research, Vol.27, No.1, pp. 29-38, 2019, DOI:10.3727/096504018X15179694020751

Abstract Artemis is a key protein of NHEJ (nonhomologous end joining), which is the major pathway for the repair of IR-induced DSBs in mammalian cells. However, the expression of Artemis in tumors and the influence of silencing Artemis on tumor sensitivity to radiation have not been investigated fully. In this study, we investigated how the expression levels of Artemis may affect the treatment outcome of radiotherapy and chemotherapy in colorectal cancer cells. First, we found that the expression of Artemis is strong in some human rectal cancer samples, being higher than in adjacent normal tissues using… More >

Fan-Chun Meng, Jun-Kai Lin

Oncology Research, Vol.27, No.2, pp. 139-146, 2019, DOI:10.3727/096504018X15185747911701

Abstract Inhibition of tumor metastasis is one of the most important purposes in colorectal cancer (CRC) treatment. This study aimed to explore the effects of liquiritigenin, a flavonoid extracted from the roots of Glycyrrhiza uralensis Fisch, on HCT116 cell proliferation, invasion, and epithelial-to-mesenchymal transition (EMT). We found that liquiritigenin significantly inhibited HCT116 cell proliferation, invasion, and the EMT process, but had no influence on cell apoptosis. Moreover, liquiritigenin remarkably reduced the expression of runt-related transcription factor 2 (Runx2) in HCT116 cells. Overexpression of Runx2 obviously reversed the liquiritigenininduced invasion and EMT inhibition. Furthermore, liquiritigenin inactivated the More >