Lijian Xu^1,2, Lekang Yin³, Fuyou Liang^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 71-72, 2019, DOI:10.32604/mcb.2019.05741

Abstract Recent studies have revealed that aortic valve diseases are associated with the increased incidence of the aortopathy development. However, the influence of aortic valve diseases on aortic hemodynamics remains unclear. The purpose of this study was therefore to investigate the hemodynamic differences in patients with and without aortic valve disease through patient-specific simulations performed on two aorta models (BAV with severe stenosis vs. normal tricuspid aortic valve (TAV)). Realistic geometries and boundary conditions were obtained from computed tomography angiography (CTA) and phase-contrast magnetic resonance imaging (PC-MRI) measurements, respectively. In addition, 4D-MRI were performed to validate More >

Zhe Liu¹, Charlie Maere^1,*, Yuqing Song¹

CMC-Computers, Materials & Continua, Vol.59, No.2, pp. 669-686, 2019, DOI:10.32604/cmc.2019.04590

Abstract Accurately finding the region of interest is a very vital step for segmenting organs in medical image processing. We propose a novel approach of automatically identifying region of interest in Computed Tomography Image (CT) images based on temporal and spatial data . Our method is a 3 stages approach, 1) We extract organ features from the CT images by adopting the Hounsfield filter. 2)We use these filtered features and introduce our novel approach of selecting observable feature candidates by calculating contours’ area and automatically detect a seed point. 3) We use a novel approach to More >

Jeong Yong Jeon^*1, Misu Lee^*†1, Sang Hyun Whang^*, Jung-Whan Kim^‡, Arthur Cho^*, Mijin Yun^*

Oncology Research, Vol.26, No.1, pp. 71-81, 2018, DOI:10.3727/096504017X14902648894463

Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal [¹⁸F]fluorodeoxyglucose (FDG) and [¹¹C]acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells. In this study, we evaluated the mechanism and roles of [¹¹C]acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of [¹¹C]acetate uptake in HCC cell lines and human HCCs with different [¹¹C]acetate uptake. Using two representative cell lines with widely different [¹¹C]acetate uptake (HepG2 for high… More >

Lidia R. Bons¹, Lucas Uchoa de Assis¹, Silvy Dekker¹, Robert M. Kauling¹, Judith A.A.E. Cuypers¹, Hence J.M. Verhagen², Ricardo P.J. Budde³, Jolien W. Roos‐Hesselink¹

Congenital Heart Disease, Vol.13, No.6, pp. 988-996, 2018, DOI:10.1111/chd.12663

Abstract Objective: The aim is to present current clinical practice of thoracic aorta screening in a tertiary referral center. We identified how often imaging techniques were used for screening and established the value of transthoracic echocardiography (TTE) in com‐ parison with computed tomography (CT) to detect aortic dilation. We also investigated which additional abnormalities of the heart, aorta or smaller arteries were discovered.
Design: All patients ≥15 years who visited our tertiary center in 2012‐2016 for first thoracic aortic screening were retrospectively included. Diameters of the sinus of Valsalva (SoV) and maximum ascending aorta (AA) were compared between… More >

S. Gopalakrishnan^{1, *}, A. Kandaswamy²

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 141-152, 2018, DOI:10.3970/cmes.2018.114.141

Abstract Delineation of the lung parenchyma in the thoracic Computed Tomography (CT) is an important processing step for most of the pulmonary image analysis such as lung volume extraction, lung nodule detection and pulmonary vessel segmentation. An automatic method for accurate delineation of lung parenchyma in thoracic Computed Tomography images is presented in this paper. The proposed method involves a segmentation phase followed by a lung boundary correction technique. The tissues in the thoracic Computed Tomography can be represented by a number of Gaussians. We propose a histogram utilized Adaptive Multilevel Thresholding (AMT) for estimating the More >

Raunak D. Patel, Colton Walker, Daniel J. Canter

Canadian Journal of Urology, Vol.24, No.1, pp. 8670-8672, 2017

Abstract Diffuse large B-cell lymphomas (DLBCL) are the most common lymphomas worldwide. They also appear to be the most common primary retroperitoneal lymphomas, but this presentation is relatively uncommon in the literature. Retroperitoneal masses, including lymphomas, often present with nonspecifc symptoms and laboratory values, necessitating radiographic assessment and consideration of mass biopsy prior to the initiation of treatment. Here we present a case of a primary retroperitoneal DLBCL as well as a review of the clinical presentation, imaging fndings, and differential diagnosis of such tumors. More >

Athanasios Koutsoukis¹, Xavier Halna du Fretay², Patrick Dupouy³, Phalla Ou⁴, Jean-Pierre Laissy⁴, Jean-Michel Juliard⁵, Fabien Hyafil⁶, Pierre Aubry⁵

Congenital Heart Disease, Vol.12, No.6, pp. 726-732, 2017, DOI:10.1111/chd.12504

Abstract Objective: The diagnosis of anomalous connections of the coronary arteries (ANOCOR) requires an appropriate identification for the management of the patients involved. We studied the observer variability in the description and classification of ANOCOR between a nonexpert group of physicians and a group of expert physicians, using the ANOCOR cohort.
Patients and design: Consecutive patients identified by 71 referring cardiologists were included in the ANOCOR cohort. Anomalous connection was diagnosed by invasive and/or computed tomography coronary angiography. Angiographic images were reviewed by an angiographic committee with experience in this field. Both investigators and angiographic committee filled out… More >

Waldemar F. Carlo¹, Steven T. Clark², Santiago Borasino³, Jeffrey A. Alten³

Congenital Heart Disease, Vol.12, No.4, pp. 540-545, 2017, DOI:10.1111/chd.12482

Abstract Objective: Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass (CBP) for cardiac surgery in neonates. It is unclear if exposure to computed tomography angiography (CTA) in the preoperative period increases the risk of AKI. We hypothesized a short interval between CTA and CPB surgery would be associated with higher rates of AKI in infants.
Design: In this single center retrospective review of patients between 2012 and 2015, neonates less than one month old were analyzed if they had CTA prior to cardiac surgery with CPB. Baseline, demographic, fluid balance, and laboratory data was analyzed.… More >

Christoph Gräni, Dominik C. Benz, Mathias Possner, Olivier F. Clerc, Fran Mikulicic, Jan Vontobel, Julia Stehli, Tobias A. Fuchs, Aju P. Pazhenkottil, Oliver Gaemperli, Philipp A. Kaufmann, Ronny R. Buechel

Congenital Heart Disease, Vol.12, No.1, pp. 49-57, 2017

Abstract Objective: To provide data on the value of fused cardiac hybrid imaging with coronary computed tomography angiography (CCTA) and positron emission tomography myocardial perfusion imaging (PET-MPI) in patients with complex coronary artery anomalies (CCAA).
Design/setting: This is a retrospective, single-center study.
Patients: Seven consecutive patients with CCAA (mean 57 ± 7 y, 86% were male) who underwent clinically indicated hybrid CCTA/PET-MPI between 2005 and 2015 in our clinic were included. The findings from both modalities and fused cardiac hybrid imaging were evaluated in these patients.
Results: Out of the seven patients with CCAA, two patients had Bland–White–Garland anomaly, two… More >

Clinton D. Bahler¹, K. Clint Cary¹, Swapnil Garg¹, Eric M. DeRoo¹, Christian H. Tabib¹, Jagan K. Kansal¹, M. Francesca Monn¹, Chandra K. Flack¹, Timothy A. Masterson¹, M. Kumar Sandrasegaran², Richard S. Foster¹, Chandru P. Sundaram¹

Canadian Journal of Urology, Vol.22, No.3, pp. 7788-7796, 2015

Abstract Introduction: To assess whether volumetric measurements can differentiate functional changes between reconstructive techniques after partial nephrectomy.
Materials and methods: One hundred and fifty-six patients undergoing partial nephrectomy for a single renal mass were retrospectively studied between 2008 and 2012. Computed tomography scans were available for volume calculations on 56 (18 non-renorrhaphy and 38 renorrhaphy). Institutional review board approval was obtained. The primary outcome was % volume loss in the operated kidney, which was calculated from three-dimensional reconstructions using a semiautomatic segmentation algorithm. Multivariable regression and propensity score analysis was performed.
Results: Volumetric analysis detected a difference… More >