Andrzej Torbé, Ryszard Czajka, Agnieszka Kordek, Rafał Rzepka, Sebastian Kwiatkowski, Jacek Rudnicki

European Cytokine Network, Vol.18, No.2, pp. 57-62, 2007, DOI:10.1684/ecn.2007.0092

Abstract Our aim was to compare maternal serum concentrations of interleukin(IL)-1α IL-1β, IL-6 and IL-8 in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at approximately full-term, and to determine if these assays have any value in the prediction of early-onset neonatal infection or histological chorioamnionitis. The study population consisted of 65 women with new-onset PTL, and 31 healthy controls. Maternal serum concentrations of IL-6 (8.40 versus 3.30 pg/mL; p = 0.002) and IL-1β (2.20 versus 0.50 pg/mL; p = 0.003) were significantly higher in patients with PTL as compared to healthy… More >

Gregory B. Pott^1,2, Carrie A. Sailer^1,2, Reuven Porat³, Robert L. Peskind^4,*, Amy C. Fuchs³, Jonathan B. Angel⁵, Paul R. Skolnik⁶, Mark A. Jacobson⁷, Michael F. Giordano^8,*, Alexandre LeBeaut^9,*, Paul C. Grint^9,*, Charles A. Dinarello¹, Leland Shapiro^1,2

European Cytokine Network, Vol.18, No.2, pp. 49-58, 2007, DOI:10.1684/ecn.2007.0094

Abstract Interleukin (IL)-10 suppresses synthesis of the pro-inflammatory cytokines tumor necrosis factor (TNF)α, IL-1b, and interferon (IFN)γ. Since pro-inflammatory cytokines have been implicated in the production of human immunodeficiency virus type 1 (HIV-1), cytokine synthesis in whole blood cultures were determined during a 4-week course of subcutaneous IL-10 injections in 33 HIV-1-infected patients. Patients were randomized into four groups: placebo (nine), IL-10 at 1 lg/kg/day (nine), IL-10 at 4 lg/kg/day (six) and IL-10 at 8 lg/kg three times per week (nine). Whole blood was obtained at the beginning and conclusion of the study and was stimulated… More >

Gregory B. Pott^1,2, Carrie A. Sailer^1,2, Reuven Porat³, Robert L. Peskind^4,*, Amy C. Fuchs³, Jonathan B. Angel⁵, Paul R. Skolnik⁶, Mark A. Jacobson⁷, Michael F. Giordano^8,*, Alexandre LeBeaut^9,*, Paul C. Grint^9,*, Charles A. Dinarello¹, Leland Shapiro^1,2

European Cytokine Network, Vol.18, No.2, pp. 1-10, 2007, DOI:10.1684/ecn.2007.0094

Abstract Interleukin (IL)-10 suppresses synthesis of the pro-inflammatory cytokines tumor necrosis factor (TNF)α, IL-1β, and interferon (IFN)γ. Since pro-inflammatory cytokines have been implicated in the production of human immunodeficiency virus type 1 (HIV-1), cytokine synthesis in whole blood cultures were determined during a 4-week course of subcutaneous IL-10 injections in 33 HIV-1-infected patients. Patients were randomized into four groups: placebo (nine), IL-10 at 1 lg/kg/day (nine), IL-10 at 4 lg/kg/day (six) and IL-10 at 8 lg/kg three times per week (nine). Whole blood was obtained at the beginning and conclusion of the study and was stimulated… More >

Jesus F. Bermejo-Martin¹, Maria C. Garcia-Arevalo¹, Raul Ortiz De Lejarazu², Julio Ardura³, Jose M. Eiros², Ana Alonso³, Vanesa Matías³, Maria Pino³, David Bernardo¹, Eduardo Arranz¹, Alfredo Blanco-Quiros¹

European Cytokine Network, Vol.18, No.3, pp. 162-167, 2007, DOI:10.1684/ecn.2007.0096

Abstract Profiling of immune mediators in both nasal and plasma samples is a common approach to the study of pathogenesis in respiratory viral infections. Nevertheless, mucosal immunity functions essentially independently from peripheral immunity. In our study, 27 immune mediators were profiled in parallel, in nasopharyngeal aspirates (NPAs) and plasma from 22 < 2 year-old children with a severe respiratory syncytial virus infection involving the lower respiratory tract, using a multiplex assay. NPAs from 22 children with innocent heart murmurs were used as controls. Differences in mediator concentrations between NPAs from patients and controls were assessed using… More >

Jesus F. Bermejo-Martin¹, Maria C. Garcia-Arevalo¹, Raul Ortiz De Lejarazu², Julio Ardura³, Jose M. Eiros², Ana Alonso³, Vanesa Matías³, Maria Pino³, David Bernardo¹, Eduardo Arranz¹, Alfredo Blanco-Quiros¹

European Cytokine Network, Vol.18, No.3, pp. 45-50, 2007, DOI:10.1684/ecn.2007.0096

Abstract Profiling of immune mediators in both nasal and plasma samples is a common approach to the study of pathogenesis in respiratory viral infections. Nevertheless, mucosal immunity functions essentially independently from peripheral immunity. In our study, 27 immune mediators were profiled in parallel, in nasopharyngeal aspirates (NPAs) and plasma from 22 < 2 year-old children with a severe respiratory syncytial virus infection involving the lower respiratory tract, using a multiplex assay. NPAs from 22 children with innocent heart murmurs were used as controls. Differences in mediator concentrations between NPAs from patients and controls were assessed using… More >

Kyriaki Venetsanou¹, Konstantinos Vlachos², Athanassios Moles¹, Gerassimos Fragakis², George Fildissis¹, George Baltopoulos¹

European Cytokine Network, Vol.18, No.4, pp. 206-209, 2007, DOI:10.1684/ecn.2007.0112

Abstract Traumatic brain injury (TBI) acts as an inducer of the inflammatory reaction expressed by the release of pro-inflammatory cytokines (interleukin-1b [IL-1b], interleukin-6 [IL-6] and interleukin-8 [IL-8]), and causes metabolic alterations in the early, post-traumatic state, either in the brain or/and the systemic circulation. The metabolic changes involve carbohydrates, proteins and lipids. We focused on the serum lipid profile, the impact of trauma on lipoproteins, and their subsequent effects, on inflammation. We investigated the role of cytokines and serum lipids, in patient outcome, reviewing 30-day mortality and the Glasgow Coma Scale (GCS). A total of 75… More >

Kyriaki Venetsanou¹, Konstantinos Vlachos², Athanassios Moles¹, Gerassimos Fragakis², George Fildissis¹, George Baltopoulos¹

European Cytokine Network, Vol.18, No.4, pp. 39-42, 2007, DOI:10.1684/ecn.2007.0112

Abstract Traumatic brain injury (TBI) acts as an inducer of the inflammatory reaction expressed by the release of pro-inflammatory cytokines [interleukin-1b (IL-1b), interleukin-6 (IL-6) and interleukin-8 (IL-8)], and causes metabolic alterations in the early, post-traumatic state, either in the brain or/and the systemic circulation. The metabolic changes involve carbohydrates, proteins and lipids. We focused on the serum lipid profile, the impact of trauma on lipoproteins, and their subsequent effects, on inflammation. We investigated the role of cytokines and serum lipids, in patient outcome, reviewing 30-day mortality and the Glasgow Coma Scale (GCS). A total of 75… More >

European Cytokine Network, Vol.17, Suppl.1, pp. 36-48, 2006

Abstract This article has no abstract. More >

European Cytokine Network, Vol.17, Suppl.1, pp. 19-20, 2006

Abstract This article has no abstract. More >

European Cytokine Network, Vol.17, Suppl.1, pp. 18-18, 2006

Abstract This article has no abstract. More >