Submit

Login Login

Register Register

Home / Advanced Search
News & Announcements

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
Show export options
  • Articles
  • Online
Search Results (151)

  • Open Access

    ARTICLE

    Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia

    Anita W. Rijneveld1,2,*, Sandrine Florquin3, Peter Speelman2,4, Carl K. Edwards5, Charles A. Dinarello6, Tom van der Poll2,4

    European Cytokine Network, Vol.14, No.4, pp. 242-245, 2003

    Abstract The inhibition of the biological activity of IL-1 by recombinant human IL-1 receptor antagonist (IL-1ra) has been investigated in several, controlled clinical trials. Encouraging results have been reported, in particular in patients with rheumatoid arthritis. In the present study, we investigated the influence of treatment of wild type mice with IL-1ra, which resulted in an incomplete and transient inhibition of IL-1 activity. Treatment with recombinant human IL-1ra resulted in an enhanced bacterial outgrowth in the lungs of BALB/c and C57BL/6 mice early after induction of pneumococcal pneumonia, without influencing survival or the pulmonary inflammatory response. More >

    View

    189

    Download

    168

Displaying 151-160 on page 16 of 151. Per Page  
First141516

Contact Us

Copyright© 2026 Tech Science Press
© 1997-2026 TSP (Henderson, USA) unless otherwise stated