Marielle K. Bouyou-Akotet1,2,3, Maryvonne Kombila3, Peter G. Kremsner1,2, Elie Mavoungou1,2
European Cytokine Network, Vol.15, No.2, pp. 120-125, 2004
Abstract During gestation, inflammatory cytokines are sometimes more abundant than growth-promoting
cytokines, and via direct or indirect effects, proinflammatory cytokines lead to intrauterine growth retardation.
We used an enzyme-linked immunosorbent assay to measure the concentrations of three proinflammatory
cytokines, tumor necrosis factor alpha (TNF-α), interleukin-12 (IL-12p40), as well as interleukin-15 (IL-15) and
monocyte chemotactic protein-1 (MCP-1), in plasma from peripheral, placental and cord blood of thirty pregnant
Gabonese women. All of these women lived in Libreville and Lambaréné, two malaria hyperendemic areas.
IL-12p40 concentrations were higher in cord blood than in placental or peripheral blood. The… More >