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  • Open Access

    ARTICLE

    Negative Pressure-induced Secretion of Inflammatory Mediators by Cultured Middle Ear Epithelial Cells: Relevance to Eustachian Tube Dysfunction and Otitis Media with Effusion

    P. A. Hebda1, M. R. Barsic1, J. E. Dohar1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 231-232, 2006, DOI:10.32604/mcb.2006.003.231

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Dual Boundary Element Method for Instability Analysis of Cracked Plates

    J. Purbolaksono1, M. H. Aliabadi2,3

    CMES-Computer Modeling in Engineering & Sciences, Vol.8, No.1, pp. 73-90, 2005, DOI:10.3970/cmes.2005.008.073

    Abstract This paper presents the dual boundary integral equations for the buckling analysis of the shear deformable cracked plates. The domain integrals which appear in this formulation are transferred to boundary integrals using the dual reciprocity method. The plate buckling displacement and hypersingular traction integral equations are presented as a standard eigenvalue problem, which would allow direct evaluation of the critical load factor and buckling modes. Several examples with different geometries and boundary conditions are presented to demonstrate the accuracy of the proposed formulation. More >

  • Open Access

    ARTICLE

    Evaluation of Tension in Actin Bundle of Endothelial Cells Based on Preexisting Strain and Tensile Properties Measurements

    S. Deguchi1,2, T. Ohashi2, M. Sato2

    Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 125-134, 2005, DOI:10.3970/mcb.2005.002.125

    Abstract Actin bundles in vascular endothelial cells (ECs) play a critical role in transmitting intracellular forces between separate focal adhesion sites. However, quantitative descriptions of tension level in single actin bundles in a physiological condition are still poorly studied. Here, we evaluated magnitude of preexisting tension in a single actin bundle of ECs on the basis of measurements of its preexisting stretching strain and tensile properties. Cultured ECs expressing fluorescently-labeled actin were treated with detergents to extract acin bundles. One end of an actin bundle was then dislodged from the substrate by using a microneedle, resulting… More >

  • Open Access

    ARTICLE

    On the Stability of the Hadley Flow under the Action of an Acoustic Wave

    M.K. Achour1, S. Kaddeche2, A. Gharbi2, H. Ben Hadid3, D. Henry3

    FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.4, pp. 277-284, 2005, DOI:10.3970/fdmp.2005.001.277

    Abstract The effects of an acoustic wave on the instabilities occurring in a lateral differentially heated cavity are investigated numerically. Linear stability results show that the acoustic wave affects significantly the instability characteristics of such a Hadley flow. Indeed, the sound field is found to stabilize both two dimensional transverse stationary and three dimensional longitudinal oscillatory instabilities which are the most critical modes affecting the buoyant convection in the fluid layer. Nevertheless, when stabilized by an acoustic wave, the 2D modes turn from stationary to oscillatory, with the known consequences of such a change on mass More >

  • Open Access

    ARTICLE

    3--D Numerical Analysis of the Stress State Caused by Short-Term Loading of a Fixed Dental Implant containing a "PDL-Like'' Nonlinear Elastic Internal Layer

    Francesco Genna1, Corrado Paganelli2, Stefano Salgarello3, Pierluigi Sapelli2

    CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 405-420, 2003, DOI:10.3970/cmes.2003.004.405

    Abstract We study the mechanical behavior of a prototype osseointegrated dental implant containing a thin internal layer, designed in such a way as to simulate the existence of the periodontal ligament (PDL). Experimental stress-strain curves suggest that the behavior of the PDL can be simulated by means of a compressible hyperelastic constitutive model, at least for short-term loading. We have adopted one such a model to describe the mechanical behavior of the internal layer in the prototype implant design, studied by means of several 3--D Finite Element analyses. The results indicate that the presence of such More >

  • Open Access

    ARTICLE

    Modeling of Electric Double Layer Effects through Pressure-driven Microchannel Flows

    E.Y.K. Ng1, S.T. Poh 2

    CMES-Computer Modeling in Engineering & Sciences, Vol.3, No.3, pp. 351-366, 2002, DOI:10.3970/cmes.2002.003.351

    Abstract Advances in microfabrication technology have allowed the use of microchannels in ultra compact, very efficient heat exchangers, which capitalize on the channels large surface area to volume ratio, to transport high heat fluxes with small thermal resistances. One example is the cooling of microchips. However, research into microscale flow and heat transfer phenomena conducted by various researchers provided substantial experimental data and considerable evidence that the behaviour of fluid flow and heat transfer in microchannels without phase change may be different than that which normally occurs in larger more conventional sized channels.
    This paper describes… More >

  • Open Access

    ARTICLE

    MAADLY Spanning the Length Scales in Dynamic Fracture

    Farid F. Abraham1

    CMES-Computer Modeling in Engineering & Sciences, Vol.1, No.4, pp. 63-70, 2000, DOI:10.3970/cmes.2000.001.515

    Abstract A challenging paradigm in the computational sciences is the coupling of the continuum, the atomistic and the quantum descriptions of matter for a unified dynamic treatment of a single physical problem. We described the achievement of such a goal. We have spanned the length scales in a concerted simulation comprising the finite-element method, classical molecular dynamics, quantum tight-binding dynamics and seamless bridges between these different physical descriptions. We illustrate and validate the methodology for crack propagation in silicon. More >

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