Ricardo Palmerola1, Paul Smith2, Vanessa Elliot2, Carl T. Reese2, Frank B. Mahon2, Lewis E. Harpster2, Nikolina Icitovic1, Jay D. Raman2,3
Canadian Journal of Urology, Vol.19, No.6, pp. 6542-6547, 2012
Abstract Introduction: Indications for prostate needle biopsy (PNB) include elevated serum prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE). We evaluated a contemporary cohort of men undergoing PNB to determine cancer detection rates when stratified by DRE status.
Materials and methods: The charts of 806 men who underwent a PNB were reviewed. Serum PSA was categorized as normal or abnormal according to age-specific criteria. A normal DRE was defined as a smooth, age-appropriate, asymmetric, or uniformly enlarged prostate. An abnormal DRE was defined by either a nodule or induration. Sensitivity, specificity, and predictive values were determined for… More >