Ethan D. Grober, John Tsihlias, Michael A. S. Jewett, Joan M. Sweet, Andrew J. Evans, John Trachtenberg, Mike Robinette, Robert K. Nam

Canadian Journal of Urology, Vol.11, No.1, pp. 2157-2162, 2004

Abstract Objectives: To correlate the primary Gleason pattern among patients with biopsy-derived Gleason 7 tumors with the radical prostatectomy specimen Gleason grading and other clinical and pathologic outcomes.
Methods and materials: Among 474 patients who underwent radical prostatectomy for clinically localized prostate cancer between 1997-2001, 205 (43%) had Gleason 7/10 tumors on pre-operative needle biopsy. Among these patients, 148 (72.2%) were assigned a primary Gleason 3 pattern (3+4=7) and 57 (27.8%) were assigned a primary Gleason 4 pattern (4+3=7). The two groups were compared with respect to age, serum PSA levels, Gleason grade in the radical prostatectomy specimen,… More >

Francesco Genna¹, Corrado Paganelli², Stefano Salgarello³, Pierluigi Sapelli²

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 405-420, 2003, DOI:10.3970/cmes.2003.004.405

Abstract We study the mechanical behavior of a prototype osseointegrated dental implant containing a thin internal layer, designed in such a way as to simulate the existence of the periodontal ligament (PDL). Experimental stress-strain curves suggest that the behavior of the PDL can be simulated by means of a compressible hyperelastic constitutive model, at least for short-term loading. We have adopted one such a model to describe the mechanical behavior of the internal layer in the prototype implant design, studied by means of several 3--D Finite Element analyses. The results indicate that the presence of such More >

E.Y.K. Ng¹, S.T. Poh ²

CMES-Computer Modeling in Engineering & Sciences, Vol.3, No.3, pp. 351-366, 2002, DOI:10.3970/cmes.2002.003.351

Abstract Advances in microfabrication technology have allowed the use of microchannels in ultra compact, very efficient heat exchangers, which capitalize on the channels large surface area to volume ratio, to transport high heat fluxes with small thermal resistances. One example is the cooling of microchips. However, research into microscale flow and heat transfer phenomena conducted by various researchers provided substantial experimental data and considerable evidence that the behaviour of fluid flow and heat transfer in microchannels without phase change may be different than that which normally occurs in larger more conventional sized channels.
This paper describes… More >

Farid F. Abraham¹

CMES-Computer Modeling in Engineering & Sciences, Vol.1, No.4, pp. 63-70, 2000, DOI:10.3970/cmes.2000.001.515

Abstract A challenging paradigm in the computational sciences is the coupling of the continuum, the atomistic and the quantum descriptions of matter for a unified dynamic treatment of a single physical problem. We described the achievement of such a goal. We have spanned the length scales in a concerted simulation comprising the finite-element method, classical molecular dynamics, quantum tight-binding dynamics and seamless bridges between these different physical descriptions. We illustrate and validate the methodology for crack propagation in silicon. More >