Maximiliano GIRAUD-BILLOUD^{1, 2*}, Fernando EZQUER², Javiera BAHAMONDE², Marcelo EZQUER²

BIOCELL, Vol.41, No.1, pp. 1-12, 2017, DOI:10.32604/biocell.2017.41.001

Abstract A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy, but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the disease on both transporters in type 1 diabetes mellitus (T1DM). We used eight-weekold male C57BL/6 mice divided into two groups; one of them received the vehicle (control group), while the other received the vehicle + 200 mg/kg streptozotocin (T1DM). Ten weeks after the injection, we evaluated plasma insulin, enzymuria, urinary vitamin D-binding protein (VDBP), tubulointerstitial fibrosis and proximal… More >

S.S. Bombicino^*, D.E. Iglesias, I.A. Rukavina Mikusic, A. Boveris, L.B. Valdez

BIOCELL, Vol.40, No.1, pp. 7-10, 2016, DOI:10.32604/biocell.2016.40.007

Abstract Diabetic cardiomyopathy, i.e. the ventricular dysfunction in the absence of hypertension or coronary arterial disease, is a common complication of diabetes mellitus that leads to a heightened risk of heart failure and death among diabetic patients. This contractile dysfunction could be associated to mitochondrial dysfunction, in which mitochondrial biogenesis could emerge as a compensatory mechanism triggered in response to hyperglycemia. It has been proposed that nitric oxide synthase activities with enhanced NO production are involved in this process. Alterations in the contractile response and lusitropic reserve were observed in streptozotocin diabetic rats after β-adrenergic stimuli. Additionally,… More >

Marzena Dworacka¹, Ewa Krzyz̀agórska², Saule Iskakova³, Yerbol Bekmukhambetov⁴, Olzhas Urazayev⁴, Grzegorz Dworacki⁵

European Cytokine Network, Vol.25, No.3, pp. 46-51, 2014, DOI:10.1684/ecn.2014.0355

Abstract Aim:The pro-atherogenic role of RANTES, a chemokine expressing pleiotropic activities, in the course of type 2 diabetes-related atherosclerosis has been well documented. However, it is not known which of the diabetes-related factors primarily influence serum RANTES levels in patients with type 2 diabetes. Our aim was to investigate relationships between several factors known to be related to an increased risk of atherosclerosis and serum RANTES levels in type 2 diabetic patients. Methods: A total of 168 subjects were examined, which included 138 patients with type 2 diabetes and 30 non-diabetic controls. Measurements of venous, fasting,… More >

Afsaneh Morteza¹, Manouchehr Nakhjavani¹, Firuzeh Asgarani¹, Azam Ghaneei², Alireza Esteghamati¹, Hossein Mirmiranpour

European Cytokine Network, Vol.24, No.1, pp. 53-59, 2013, DOI:10.1684/ecn.2013.0329

Abstract C reactive protein (CRP) is an inflammatory marker believed to be of value in the early prediction of type 2 diabetes (T2DM). Recent studies have shown a positive correlation between leptin and CRP levels. Here, we aimed to study the correlation between leptin and CRP in patients with T2DM. We also studied the effect of metformin therapy on the CRP-leptin correlation in patients with newly diagnosed diabetes. We performed a follow-up study on three groups of participants defined as 1: patients with newly diagnosed T2DM, 2: patients with long-standing T2DM, and 3: healthy controls. Patients… More >

Afsaneh Morteza, Manouchehr Nakhjavani, Akram Ghadiri-Anari, Alireza Esteghamati, Omid Khalilzadeh

European Cytokine Network, Vol.22, No.2, pp. 107-112, 2011, DOI:10.1684/ecn.2011.0282

Abstract Introduction. In vitro studies have shown that oxidized, low density lipoprotein (ox-LDL) stimulates macrophages to release interleukin-6 (IL-6) and interleukin-1β (IL-1β). In this study, we aimed to investigate the correlation between ox-LDL and IL-6 and IL-1β levels in the peripheral circulation of patients with type 2 diabetes, and normal controls. We measured serum high sensitivity CRP (hs-CRP) levels in order to define basal inflammation in patients and controls. Methods. A total of 40 patients with type 2 diabetes, and 40, age, sex, and body mass index (BMI) -matched healthy adults were enrolled in the study.… More >

VIJAY L. KUMAR^* AND BISWA M. PADHY

BIOCELL, Vol.35, No.3, pp. 63-70, 2011, DOI:10.32604/biocell.2011.35.063

Abstract Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in… More >

Mouna Stayoussef¹, Jihen Benmansour¹, Fayza A. Al-Jenaidi^2,3, Mansoor H. Rajab², Hichem B. Said⁴, Mohamed Ourtani⁵, Chiheb B. Rayana¹, Touhami Mahjoub¹, Wassim Y. Almawi³

European Cytokine Network, Vol.21, No.4, pp. 285-291, 2010, DOI:10.1684/ecn.2010.0215

Abstract Aim. We investigated the association of tumor necrosis factor (TNF)α gene polymorphism with type 1 diabetes (T1D). Methods. TNF-α -1031T/C, -863C/A, -857C/T, -376G/A, -308G/A, -238G/A, and +488G/A single nucleotide polymorphisms (SNPs) were assessed in 198 T1DM patients and 180 age-and gender-matched, normoglycemic control subjects using PCR-restriction fragment length polymorphism (RFLP). Results. Higher frequencies of -863A (p = 8.0 × 10^-6 ), -857T (p = 1.4 × 10^-4 ), and -238A (p = 0.002) alleles were seen in T1D patients than in the control group. Significant differences were noted in the distribution of -863T/C, -857C/T, -376G/A, -308G/A,… More >

Lukas A. Berchtold^1,2, Claus M. Larsen², Allan Vaag², Mirjam Faulenbach³, Christopher T. Workman⁴, Mogens Kruhøffer⁵, Marc Donath³, Thomas Mandrup-Poulsen^1,2,6

European Cytokine Network, Vol.20, No.2, pp. 81-87, 2009, DOI:10.1684/ecn.2009.0152

Abstract Background. We have previously reported that systemic blockade of IL-1β in patients with type 2 diabetes with anakinra (a recombinant human interleukin-1-receptor antagonist, IL-1Ra), lowered glycated hemoglobin improved beta-cell function and reduced circulating levels of IL-6 and CRP (7). To investigate the effects of IL-1Ra in insulin-sensitive tissue, gene expression levels in skeletal muscle from type 2 diabetic patients treated with IL-1Ra were analysed. Methods. Gene expression profiles in vastus lateralis muscle biop-sies from five obese patients (BMI >27) were determined before and after 13 weeks of treatment with IL-1Ra (anakinra) using Affymetrix U133Plus2.0 GeneChips.… More >

JACQUELINE NELISIS ZANONI, RENATA VIRGINIA FERNANDES PEREIRA

BIOCELL, Vol.32, No.2, pp. 163-168, 2008, DOI:10.32604/biocell.2008.32.163

Abstract The objective of this work was to evaluate the effect of the ascorbic acid supplementation on the cellular proliferation on the ileum mucosa of diabetic rats. Fifteen 90-days rats were divided in the groups: control, diabetic and diabetic supplemented with ascorbic acid (DA). Two hours prior the sacrifice, they were injected with Vincristin. Semi-seriate histological cuts stained with HE were accomplished. About 2500 crypt cells from the intestinal mucosa were counted in order to obtain the metaphasic indexes. The height and depth of 30 villi and 30 crypts were measured for each animal, respectively. The… More >

Jean-Philippe Bastard¹, Mustapha Maachi¹, Claire Lagathu¹, Min Ji Kim¹, Martine Caron¹, Hubert Vidal², Jacqueline Capeau¹, Bruno Feve³

European Cytokine Network, Vol.17, No.1, pp. 4-12, 2006

Abstract It now appears that, in most obese patients, obesity is associated with a low-grade inflammation of white adipose tissue (WAT) resulting from chronic activation of the innate immune system and which can subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes. WAT is the physiological site of energy storage as lipids. In addition, it has been more recently recognized as an active participant in numerous physiological and pathophysiological processes. In obesity, WAT is characterized by an increased production and secretion of a wide range of inflammatory molecules including TNF-α and interleukin-6 (IL-6), which… More >