Jolanta Myśliwska¹, K. Zorena¹, E. Semetkowska-Jurkiewicz², D. Rachoń¹, H. Suchanek¹, A. Myśliwski³

European Cytokine Network, Vol.16, No.2, pp. 117-122, 2005

Abstract Aims. The aim of our study was to analyse the level of circulating interleukin-10 (IL-10) and relate it to the grade of albuminuria in patients with diabetic nephropathy (DN) due to type 1 diabetes mellitus (DM). Since IL-10 has met the criteria for an anti-inflammatory and an immunosuppressive cytokine, its activity may be important for clinical outcome of DN. Methods. The IL-10 level was measured by ELISA in serum samples from thirty patients with DN due to type 1 DM, and compared with thirty patients with type 1 DM without DN and a control group… More >

Hanna Suchanek¹, Jolanta Mys´liwska¹, Janusz Siebert², Joanna WiVckiewicz¹, Łukasz Hak¹, Krzysztof Szyndler³, Dorota Kartanowicz⁴

European Cytokine Network, Vol.16, No.3, pp. 177-185, 2005

Abstract Aims. The aim of our study was to analyse the serum level of interleukin 18 (IL-18) in coronary artery disease (CAD) patients with type 2 diabetes mellitus (DM), and to relate this to clinical findings. Methods. The IL-18 level was measured by ELISA in serum samples from 130 CAD patients prior to their first, elective, coronary artery bypass surgery. Forty-three of them had been diabetic for several years. A control group consisted of 31 healthy people matched according to age, BMI, lipid and smoking status. Results. The CAD patients with DM were similar to the… More >

Csaba Hermann^1,5, Dóra Krikovszky², George Füst³, Margit Kovács³, Anna Körner⁴, András Szabó⁴, Ádám Vannay², László Madácsy²

European Cytokine Network, Vol.16, No.4, pp. 277-281, 2005

Abstract Multiple immune mediators have been mentioned as playing a role in the pathomechanism of type1 DM. Interleukin (IL)-1β, and tumor necrosis factor (TNF)-α play a central role in the autoimmune destruction of pancreatic b-cells, whereas IL-6 inhibits TNF-α secretion, and may have some protecting effects. In our study, we aimed to investigate the association between these three cytokines’ single nucleotide polymorphisms (IL-6 gene G(-174)C, TNF-α gene G(-308)A and IL-1β gene C(3954)T polymorphisms) and age-at-onset of type 1 diabetes mellitus (T1DM) in 165 diabetic children (median age: 17 years). Polymorphisms were determined using the PCR-RFLP method.… More >

Yih-Hsin Chang¹, Chien-Ning Huang², Ming-Yuh Shiau^3,4

European Cytokine Network, Vol.15, No.2, pp. 112-116, 2004

Abstract Chronic liver disease and cirrhosis are two of the most important health problems according to current gastroenterology literature. Based on the recent developments in the field of immunology, advanced follow-up and treatment modalities have been introduced for these disorders. Immune defence against viral infections depends on effective cellular immune responses derived mainly from Th1-related cytokines. Th2 type immune responses can inhibit efficient immune function by secretion of several cytokines such as IL-10, TGF-β1. In this particular study, we determined the serum levels of TGF-β1, which plays a role in immune suppression and induction of tissue… More >

Claudio Pérez¹, Fermín E. González^1,2, Violeta Pavez³, Aida V. Araya⁴, Adam Aguirre¹, Andrea Cruzat^1,6, Juan Contreras-Levicoy^1,6, Andrés Dotte^1,6, Octavio Aravena¹, Lorena Salazar¹, Diego Catalán¹, Jimena Cuenca¹, Arturo Ferreira¹, Irene Schiattino⁵, Juan C. Aguillón¹

European Cytokine Network, Vol.15, No.4, pp. 364-370, 2004

Abstract Several single-nucleotide polymorphisms (SNPs) have been identified in the TNF-α gene promoter. The transition G→A at position –308 generates the TNF-α1 (G/G) and TNF-α2 (G/A or A/A) alleles, where the polymorphic TNF-α2 allele is associated with a high, in vitro TNF-α expression and an increased susceptibility to diverse illnesses. Here we study the association of the –308 TNF-α SNP with the susceptibility for developing aggressive periodontitis (AP), AP combined with type 1 diabetes mellitus (DM) and DM. We also explore the TNF-α capability expression and the presence of the –308 polymorphism. For this purpose we More >

A. Veronica Araya¹, Violeta Pavez², Claudio Perez³, Fermin Gonzalez³, Alicia Colombo³, Adam Aguirre³, Irene Schiattino⁴, Juan C. Aguillón³

European Cytokine Network, Vol.14, No.3, pp. 128-133, 2003

Abstract Several studies have demonstrated that diabetes is a risk factor for developing periodontal disease, increasing its prevalence and severity. Furthermore, periodontitis may impair the metabolic control and adequate treatment of diabetic patients. LPS from Gram-negative bacteria penetrates the periodontal tissues and subsequently recruits and activates immune cells. Progression to severe periodontitis with loss of supporting structures is mediated by several factors, including secretion of a broad spectrum of inflammatory and destructive mediators such as cytokines (TNF-α, IL-1β and IL-6), chemokines (IL-8) and prostaglandin E₂ (PGE₂).
The aim of this work is to investigate differences in the… More >