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  • Open Access

    CASE REPORT

    Transitional cell carcinoma of the bladder producing Parathyroid hormone-related protein (PTHrP)

    Uzair B. Chaudhary1, David L. Milling1, Nabil K. Bissada2

    Canadian Journal of Urology, Vol.11, No.1, pp. 2136-2138, 2004

    Abstract Hypercalcemia associated with transitional cell carcinoma (TCC) is rarely encountered. We report a case of TCC of bladder with documented production of parathyroid hormone related protein (PTHrP). Our patient had a rapidly progressive course and died 2 months after radical cystectomy. Literature suggests that these patients present with advanced stage and carry a poor prognosis. The histopathologic features, treatment and prognosis associated with this rare paraneoplastic syndrome are reviewed. More >

  • Open Access

    RESIDENT’S CORNER

    Bladder leiomyoma: report of two cases and literature review

    S. Binsaleh1,2, J. Corcos1, M. M. Elhilali2, S. Carrier1

    Canadian Journal of Urology, Vol.11, No.5, pp. 2411-2413, 2004

    Abstract Mesenchymal tumors of the urinary bladder are rare and the majority of them are malignant. We report two cases of leiomyoma of the urinary bladder presenting with symptoms of bladder outlet obstruction. The first patient was managed with staged transurethral resections, and the second with holmium laser transurethral inoculation. The outcome was excellent in both cases. A review of the literature is also outlined. More >

  • Open Access

    ARTICLE

    Protein detection in spermatids and spermatozoa of the butterfly Euptoieta hegesia (Lepidoptera)

    KARINA MANCINI, HEIDI DOLDER

    BIOCELL, Vol.28, No.3, pp. 299-310, 2004, DOI:10.32604/biocell.2004.28.299

    Abstract This study was undertaken to detect protein components in both sperm types of the butterfly Euptoieta hegesia. These spermatozoa possess complex extracellular structures for which the composition and functional significance are still unclear. In the apyrene sperm head, the proteic cap presented an external ring and an internal dense content; basic proteins were detected only in external portions. In the tail, the paracrystalline core of mitochondrial derivatives and the axoneme are rich in proteins. The extratesticular spermatozoa are covered by a proteic coat, which presented two distinct layers. In eupyrene spermatozoa, acrosome and nucleus were negatively… More >

  • Open Access

    ARTICLE

    Cantilever Arrays for Multiplexed Mechanical Analysis of Biomolecular Reactions

    Min Yue1,1, Jeanne C. Stachowiak1,1,2,2, Arunava Majumdar1,1,3,3

    Molecular & Cellular Biomechanics, Vol.1, No.3, pp. 211-220, 2004, DOI:10.3970/mcb.2004.001.211

    Abstract Microchips;ontaining arrays of cantilever beams have been used to mechanically detect and quantitatively analyze multiple reactions of DNA hybridization and antigen-antibody binding simultaneously. The reaction-induced deflection of a cantilever beam reflects the interplay between strain energy increase of the beam and the free energy reduction of a reaction, providing an ideal tool for investigating the connection between mechanics and chemistry of biomolecular reactions. Since free energy reduction is common for all reactions, the cantilever array forms a universal platform for label-free detection of various specific biomolecular reactions. A few such reactions and their implications in More >

  • Open Access

    ARTICLE

    Weight-Minimization of Sandwich Structures by a Heuristic Topology Optimization Algorithm

    C. Tapp1, W. Hansel, C. Mittelstedt, W. Becker2

    CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.6, pp. 563-574, 2004, DOI:10.3970/cmes.2004.005.563

    Abstract A heuristic algorithm for the weight minimization of sandwich plates is presented. The method is based on a preexisting algorithm for the layerwise topology optimization of symmetric laminates under in-plane loads. The presented algorithm uses structural analyses based on finite elements and explicitly accounts for the special sandwich situation. During the optimization procedure the algorithm adds or subtracts material from the layers of the face sheets and the core of the sandwich plate in regions of high or low stresses respectively. The orientation angles of the layers of the sandwich facings are not varied inorder More >

  • Open Access

    ARTICLE

    Directly Derived Non-Hyper-Singular Boundary Integral Equations for Acoustic Problems, and Their Solution through Petrov-Galerkin Schemes

    Z.Y. Qian1, Z.D. Han1, S.N. Atluri1

    CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.6, pp. 541-562, 2004, DOI:10.3970/cmes.2004.005.541

    Abstract Novel non-hyper-singular [i.e., only strongly-singular] boundary-integral-equations for the gradients of the acoustic velocity potential, involving only O(r−2) singularities at the surface of a 3-D body, are derived, for solving problems of acoustics governed by the Helmholtz differential equation. The gradients of the fundamental solution to the Helmholtz differential equation for the velocity potential, are used in this derivation. Several basic identities governing the fundamental solution to the Helmholtz differential equation for velocity potential, are also derived. Using these basic identities, the strongly singular integral equations for the potential and its gradients [denoted here as φ-BIE, and… More >

  • Open Access

    ARTICLE

    Large Scale Parallel Simulation and Visualization of 3D Seismic Wavefield \\ Using the Earth Simulator

    T. Furumura1, L. Chen2

    CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.2, pp. 153-168, 2004, DOI:10.3970/cmes.2004.006.153

    Abstract Recent developments of the Earth Simulator, a high-performance parallel computer, has made it possible to realize realistic 3D simulations of seismic wave propagations on a regional scale including higher frequencies. Paralleling this development, the deployment of dense networks of strong ground motion instruments in Japan (K-NET and KiK-net) has now made it possible to directly visualize regional seismic wave propagation during large earthquakes. Our group has developed an efficient parallel finite difference method (FDM) code for modeling the seismic wavefield and a 3D visualization technique, both suitable for implementation on the Earth Simulator. Large-scale 3D… More >

  • Open Access

    CORRECTION

    Erratum: "Directly Derived Non-Hyper-Singular Boundary Integral Equations for Acoustic Problems, and Their Solution through Petrov-Galerkin Schemes" CMES:Computer Modeling in Engineering & Sciences, vol. 5, no. 6, pp. 541-562.

    Z.Y. Qian1, Z.D. Han1, S.N. Atluri1

    CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.1, pp. 115-122, 2004, DOI:10.3970/cmes.2004.006.115

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Multi-Inclusion Unit Cell Studies of Reinforcement Stresses and Particle Failure in Discontinuously Reinforced Ductile Matrix Composites

    H.J. Bohm¨ 1, W. Han1,2, A. Eckschlager1,3

    CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.1, pp. 5-20, 2004, DOI:10.3970/cmes.2004.005.005

    Abstract Three-dimensional periodic micromechanical models are used for studying the mechanical behavior of discontinuously reinforced ductile matrix composites. The models are based on unit cells that contain a number of randomly positioned and, where applicable, randomly oriented spherical, spheroidal or cylindrical reinforcements. The Finite Element method is used to resolve the microscale stress and strain fields and to predict the homogenized responses under overall uniaxial tensile loading in the elastic and elastoplastic regimes. Periodicity boundary conditions are employed in the analyses.\\ The main emphasis of the contribution is put on studying the microscale stresses in the More >

  • Open Access

    ARTICLE

    Green's First Identity Method for Boundary-Only Solution of Self-Weight in BEM Formulation for Thick Slabs

    Youssef F. Rashed1

    CMC-Computers, Materials & Continua, Vol.1, No.4, pp. 319-326, 2004, DOI:10.3970/cmc.2004.001.319

    Abstract The present paper develops a new technique for treatment of self-weight for building slabs in the boundary element method (BEM). Due to the use of BEM in the analysis, all defined variables are presented on the slab boundary (mesh is defined only along the slab boundary). Self-weight, however, is usually defined over slab domain, hence domain discretisation is required, which spoils the main advantage of the BEM. In this paper a new method is presented to transform self-weight domain integrals to the boundary for such slabs. The proposed method is based on using the so-called More >

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