Laleh Sharifi^1,2, Asghar Aghamohammadi^1,3, Nima Rezaei^3,4,5, Reza Yazdani¹, Farhad Rezaei⁶, Saied Bokaie⁷, Farzaneh Tofighi Zavareh^2,8, Fatemeh Kiaee³, Ali N. Kamali⁹, Gholamreza Azizi¹⁰, Abbas Mirshafiey^1,8

European Cytokine Network, Vol.30, No.4, pp. 123-129, 2019, DOI:10.1684/ecn.2019.0435

Abstract Introduction: Common Variable Immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiencies. Current research data show altered B cells, TLRs, and cytokine profile in CVID patients. The aim of this study was to determine levels of IL-1β and IL-6 in CVID patients in response to TLRs stimulation and the association of these cytokines with subtypes of B cells and response to Pneumovax-23 vaccination. Method: Peripheral blood mononuclear cells of CIVD patients were stimulated with and without TLR2 and TLR4 agonist and specific inhibitors including lipopolysaccharide (LPS), lipoteichoic (LTA), and OxPAPC. The levels of… More >

Sifei Yu¹, Xi Luo², Binyan Yang¹, Li Xiao¹, Xingmei Wu³, Huabin Li³, Changyou Wu¹

European Cytokine Network, Vol.30, No.4, pp. 114-122, 2019, DOI:10.1684/ecn.2015.0368

Abstract Tonsils are important lymphoid organs in which B cells and T cells complete their maturation and identify cells that are infected by pathogens. However, the functions of T cells in human tonsils remain unclear, especially the characteristics of polyfunctional CD4⁺ T helper cells. In this study, we used multi-color flow cytometry to analyze the expression or co-expression of effector cytokines in CD4⁺ T cells from tonsillar tissues. We have demonstrated that tonsillar CD4⁺ T cell can express various Th effector cytokines after short-term polyclonal stimulation, and that cytokine-producing CD4⁺ T cells were CD45RO+ T cells. In addition, More >

Jessica Costales^1,*, Muhannad Alsyouf², Phillip Napolitan³, Sharon Wang³, Brian Hu²

Canadian Journal of Urology, Vol.26, No.1, pp. 9680-9682, 2019

Abstract Corynebacterium urealyticum is an organism associated with a rare chronic urinary tract infection, which can lead to calcification of the urinary tract and promote rapid lithogenesis. This case illustrates the serious complications that can arise from chronic infection with C. urealyticum, which include rapid progression of luminal and parenchymal urinary tract calcification and concomitant renal failure. This case and a review of the literature demonstrate the need for an increased awareness of this organism with early identification, aggressive management, and test of cure that may help avoid the sequela of these infections. More >

Carlos A. Batagello^1,2, Hugo D. Barone dos Santos¹, Andrew H. Nguyen², Luay Alshara², Jianbo Li³, Giovanni Scala Marchini^1,2, Fabio C. Vicentini¹, Fabio César Miranda Torricelli^1,2, Alexandre Danilovic¹, Jessica Goulart Pereira¹, Emily Rose², Miguel Srougi¹, Willian C. Nahas¹, Eduardo Mazzucchi¹, Manoj Monga²

Canadian Journal of Urology, Vol.26, No.1, pp. 9664-9674, 2019

Abstract Introduction: The optimal patient positioning for percutaneous nephrolithotomy (PCNL) based on the complexity of stone burden is not yet defined. Thus, we aimed to evaluate the intraoperative parameters, effectiveness and complications of patients undergoing PCNL between the endoscopic-guided prone split-leg PCNL (ePSL) and the supine PCNL by stratifying patients according to Guy’s stone score (GSS).
Materials and methods: A retrospective chart review was conducted of patients undergoing PCNL at two high-volume tertiary referral centers. At one center, patients underwent PCNL using the ePSL technique, while at the second center, patients underwent PCNL in supine. Patient demographics and… More >

Nicholas J. Farber, Nadiya Chuchvara, Parth K. Modi, Joshua Sterling, Sammy E. Elsamra

Canadian Journal of Urology, Vol.26, No.1, pp. 9660-9663, 2019

Abstract Introduction: To assess whether urologists are able to accurately estimate the cost of commonly used endourologic disposable devices.
Materials and methods: An anonymous questionnaire was presented to resident and attending urologists in one academic healthcare system. Respondents estimated the cost of 15 disposable devices commonly used in ureteroscopy. Twenty-five surgeons (9 residents and 16 attending urologists) participated, for a response rate of 96.2%. Respondents’ cost estimates were compared to actual institutional costs and considered accurate if the absolute percentage error was within 20%. Additional information obtained included: years in practice, participation in purchasing activities, practice setting, number… More >

Hatim Thaker, Saum Ghodoussipour, Mateen Saffarian, Akbar Ashrafi, Gus Miranda, Jie Cai, Anne K. Schuckman, Monish Aron, Mihir Desai, Inderbir S. Gill, Siamak Daneshmand, Hooman Djaladat

Canadian Journal of Urology, Vol.26, No.1, pp. 9654-9659, 2019

Abstract Introduction: To evaluate the reasons leading to an extended hospital stay (EHS) in patients undergoing radical cystectomy (RC) with postoperative enhanced recovery after surgery (ERAS) protocol.
Materials and methods: A total of 509 patients underwent RC and urinary diversion with ERAS between May 2012 and March 2017. The protocol includes no bowel preparation, early feeding, predominantly non-narcotic pain control, and μ opioid antagonists. Non-consenting/lost to follow-up patients, and those with non-urothelial carcinoma were excluded. We defined EHS as ≥ 5 postoperative days and compared the cohort to those with a length of stay (LOS) of ≤ 4… More >

Félix Couture^1,2,*, Stefano Polesello², Côme Tholomier^2,3, Helen Davis Bondarenko², Pierre I. Karakiewicz², Sebastiano Nazzani^4,5, Felix Preisser^5,6, Assaad El-Hakim², Kevin C. Zorn⁷

Canadian Journal of Urology, Vol.26, No.1, pp. 9644-9653, 2019

Abstract Introduction: Neurovascular bundle (NVB) preservation during robot-assisted radical prostatectomy (RARP) directly affects patient functional outcomes. Despite careful surgical planning, many NVB preservation techniques are changed intraoperatively from their preoperative plan. Our objective was to identify risk factors predicting intraoperative change in NVB preservation technique during RARP.
Materials and methods: Prospective data from 578 RARPs performed by a single surgeon between 2010 and 2017 at a tertiary care center. Side-specific NVB preservation technique was planned preoperatively. Surgical techniques were either complete nerve sparing (CNS), or incomplete nerve sparing (INS). Variables included age, tumor grade, prostate volume, number of… More >

Nirmish Singla¹, Jordon T. Walker¹, Solomon L. Woldu¹, Karen De La Fuente¹, Ellen Araj², Brandon Swartz², Payal Kapur^1,2, Claus G. Roehrborn¹

Canadian Journal of Urology, Vol.26, No.1, pp. 9634-9643, 2019

Abstract Introduction: To determine whether quantifying the proximity of positive prostate biopsy cores to the capsular edge may aid in identifying patients at risk for extracapsular extension (ECE) at the time of radical prostatectomy (RP).
Materials and methods: We reviewed a single-surgeon experience of 429 systematic transrectal prostate biopsies from 2010-2014. Marking ink was applied to the capsular edge ex vivo following specimen acquisition, and the proximity of cancer to the stained capsular edge was measured. Primary outcome was ECE at RP. Demographics, PSA, DRE findings, Gleason score, core location and involvement, and RP pathology were recorded. Predictors… More >

Kevin R. Loughlin

Canadian Journal of Urology, Vol.26, No.1, pp. 9628-9629, 2019

Abstract This article has no abstract. More >

Heide Schatten

Canadian Journal of Urology, Vol.26, No.1, pp. 9627-9627, 2019

Abstract This article has no abstract. More >