P.D. Shah¹, C.L. Tan^1,2, X. Wang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.13, No.3, pp. 185-198, 2006, DOI:10.3970/cmes.2006.013.185

Abstract In this paper, the path independent mutual or M-integral for the computation of the T-stress for interface cracks between dissimilar anisotropic, linear elastic solids, is developed. The required auxiliary field solution is derived from the solution of the problem of an anisotropic composite wedge subjected to a point force at its apex. The Boundary Element Method (BEM) is employed for the numerical stress analysis in which special crack-tip elements with the proper oscillatory traction singularity are used. The successful implementation of the procedure for evaluating the T-stress in a bi-material interface crack and its application are demonstrated More >

Daiki Shiozawa¹, Shiro Kubo², Takahide Sakagami², Masaaki Takagi²

CMES-Computer Modeling in Engineering & Sciences, Vol.11, No.1, pp. 27-36, 2006, DOI:10.3970/cmes.2006.011.027

Abstract The passive electric potential CT (computed tomography) method using piezoelectric film was applied to the identification of plural through cracks. The use of piezoelectric material made it possible to obtain electric potential field without applying electric current. For identification of cracks an inverse analysis scheme based on the least residual method was applied, in which square sum of residuals is evaluated between the measured electric potential distributions and those computed by using the finite element method. Akaike information criterion (AIC) was used to estimate the number of cracks. Numerical simulations were carried out on the More >

Fred Saad

Canadian Journal of Urology, Vol.12, Suppl.1, pp. 71-76, 2005

Abstract Modern medicine offers multiple treatment options to prolong the survival of patients with prostate cancer. However, in the absence of adequate supportive care, the systemic effects of prostate cancer and therapies such as androgen deprivation therapy (ADT) can undermine skeletal integrity, resulting in skeletal complications. Skeletal morbidity contributes to the erosion in quality of life in patients with prostate cancer. These patients are at risk for fractures from cancer treatment-induced bone loss and, later on, pathologic fractures from bone metastases, which may occur during the progression of prostate cancer. Several supportive care options are available More >

H. McDonald, M. Hux, M. Brisson, L. Bernard, J.C. Nickel

Canadian Journal of Urology, Vol.12, No.1, pp. 2508-2510, 2005

Abstract This article has no abstract. More >

A. H. Feifer, B. C. Fong, L. Feldman, G. Fried, L. A. Stein, P. Metrakos, S. Bergman, M. Anidjar

Canadian Journal of Urology, Vol.12, No.3, pp. 2713-2721, 2005

Abstract Objective: To assess the efficacy of CT angiography (CTA) in evaluating the renovascular anatomy in 50 patients who underwent laparoscopic donor nephrectomy, and to correlate results with donor morbidity and recipient outcome.
Methods: Forty-eight patients were evaluated by CTA prior to laparoscopy. Donors with aberrant renovasculature and their respective recipients were divided into: 1) accurate preoperative CTA ("predictive group", PG), 2) inaccurate CTA ("non-predictive group", NPG). Warm ischemia times (WIT), estimated blood loss (EBL), operative time (OT), and the open conversion rate were compared. Recipient creatinine values on post-operative day 1 and 3 months were recorded with… More >

MARIA RAQUEL MARÇAL NATALI, SONIA LUCY MOLINARI, LUIZ CRISTIANO VALENTINI, MARCÍLIO HUBNER DE MIRANDA NETO.

BIOCELL, Vol.29, No.1, pp. 39-46, 2005, DOI:10.32604/biocell.2005.29.039

Abstract The purpose of this work was to analyze the morphoquantitative behavior of the neurons of the myenteric plexus, as well as the morphometry of the duodenal wall, in adult rats fed with normoproteic (22%) and hypoproteic (8%) rations, killed at the age of 345 days. For neuronal assessments duodenal wholemounts stained with the Giemsa method were used, and for the evaluation of the duodenal wall routine histological processing and staining with Hematoxilin-Eosin were employed. The means of the number of neurons in 80 microscopic fields (12.72 mm² ) and of the size of the neuronal cell More >

S. Deguchi^1,2, T. Ohashi², M. Sato²

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 125-134, 2005, DOI:10.3970/mcb.2005.002.125

Abstract Actin bundles in vascular endothelial cells (ECs) play a critical role in transmitting intracellular forces between separate focal adhesion sites. However, quantitative descriptions of tension level in single actin bundles in a physiological condition are still poorly studied. Here, we evaluated magnitude of preexisting tension in a single actin bundle of ECs on the basis of measurements of its preexisting stretching strain and tensile properties. Cultured ECs expressing fluorescently-labeled actin were treated with detergents to extract acin bundles. One end of an actin bundle was then dislodged from the substrate by using a microneedle, resulting… More >

Y. Tomita ¹, M. Uchida ¹

CMES-Computer Modeling in Engineering & Sciences, Vol.10, No.3, pp. 239-248, 2005, DOI:10.3970/cmes.2005.010.239

Abstract In this study, we clarified the micro- to mesoscopic deformation behavior of a semicrystalline polymer by employing a large-deformation finite element homogenization method. The crystalline plasticity theory with a penalty method for the inextensibility of the chain direction and the nonaffine molecular chain network theory were applied for the representation of the deformation behavior of the crystalline and amorphous phases, respectively, in the composite microstructure of the semicrystalline polymer. The 3D structure of lamellae in the spherulite of high-density polyethylene was modeled, and the tensile and compressive deformation behaviors were investigated. A series of computational More >

Heather McDonald¹, Margaret Hux¹, Marc Brisson², Lisa Bernard¹, J. Curtis Nickel³

Canadian Journal of Urology, Vol.11, No.4, pp. 2327-2340, 2004

Abstract Objective: The Proscar Long-Term Efficacy and Safety Study (PLESS) and the Medical Therapy of Prostatic Symptoms (MTOPS) study provide new evidence regarding the benefits of finasteride in the treatment of benign prostatic hyperplasia (BPH). The objective of this study was to utilize data from the PLESS and MTOPS studies to assess the cost-utility of finasteride and finasteride in combination with doxazosin, compared to doxazosin alone in men with moderate to severe BPH symptoms.
Methods: A semi-Markov decision analytic model was constructed to estimate the clinical consequences, costs and cost-utility of doxazosin, finasteride, and combination therapy. Analyses were… More >

Les Bowles^1,2, Hanna Bialkowska-Hobrzanska^1,2,3,4, Bernard Bukala⁵, Linda Nott⁵, Hassan Razvi^2,5

Canadian Journal of Urology, Vol.11, No.6, pp. 2438-2444, 2004

Abstract Human telomerase reverse transcriptase (hTERT) mRNA expression has been considered a surrogate marker for telomerase activity based on its parallel detection in urological malignancies, including transitional cell carcinoma (TCC) of the bladder. The objective of this study was to prospectively evaluate the diagnostic performance of urine hTERT mRNA marker and urine cytology in the detection of bladder cancer.
The multiplex hTERT/GAPDH (glyceraldehyde-3- phosphate dehydrogenase) reverse transcription polymerase chain reaction (RT-PCR) assay was employed to assess hTERT mRNA expression in urine sediments from 43 patients with clinically apparent TCC undergoing transurethral resection. Tumor grade and pathological stage… More >