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  • Open Access

    ARTICLE

    The Effect of Matrix Tension-Compression Nonlinearity and Fixed Negative Charges on Chondrocyte Responses in Cartilage

    Morakot Likhitpanichkul1, X. Edward Guo2, Van C. Mow1,3

    Molecular & Cellular Biomechanics, Vol.2, No.4, pp. 191-204, 2005, DOI:10.3970/mcb.2005.002.191

    Abstract Thorough analyses of the mechano-electrochemical interaction between articular cartilage matrix and the chondrocytes are crucial to understanding of the signal transduction mechanisms that modulate the cell metabolic activities and biosynthesis. Attempts have been made to model the chondrocytes embedded in the collagen-proteoglycan extracellular matrix to determine the distribution of local stress-strain field, fluid pressure and the time-dependent deformation of the cell. To date, these models still have not taken into account a remarkable characteristic of the cartilage extracellular matrix given rise from organization of the collagen fiber architecture, now known as the tension-compression nonlinearity (TCN)… More >

  • Open Access

    ARTICLE

    Modeling of Surface-Tension-Driven Flow of Blood in Capillary Tubes

    Jun Wang1, Wei Huang2, Raghbir S. Bhullar3, Pin Tong2

    Molecular & Cellular Biomechanics, Vol.1, No.2, pp. 161-168, 2004, DOI:10.3970/mcb.2004.001.161

    Abstract Surface-tension-driven blood flow into a capillary tube, as in some medical devices, is studied. In a previous article, we considered the early stages of the entry flow from a drop of blood into a capillary, and solved the problem analytically under the assumption that the resistance of the air is negligible. In the present note we consider a capillary tube of finite length, with the far end containing a small window which opens to the atmosphere. The dynamic reverberation of the air in the capillary tube is analyzed in conjunction with the dynamics of the… More >

  • Open Access

    ARTICLE

    Finite Element Modeling of Thin Layers

    Dan Givoli1

    CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.6, pp. 497-514, 2004, DOI:10.3970/cmes.2004.005.497

    Abstract Very thin layers with material properties which significantly differ from those of the surrounding medium appear in a variety of applications. Traditionally there are two extreme ways of handling such layers in finite element analysis: either they are fully modelled or they are totally ignored. The former option is often very expensive computationally, while the latter may lead to significant inaccuracies. Here a special technique of modeling thin layers is devised within the framework of the finite element method. This technique constitutes a prudent compromise between the two extremes mentioned above. The layer is replaced More >

  • Open Access

    ARTICLE

    Stress Concentrations Caused by Embedded Optical Fiber Sensors in Composite Laminates

    Kunigal Shivakumar1, Anil Bhargava2

    CMC-Computers, Materials & Continua, Vol.1, No.2, pp. 173-190, 2004, DOI:10.3970/cmc.2004.001.173

    Abstract The fiber optic sensor (FOS) embedded perpendicular to reinforcing fibers causes an `Eye' shaped defect. The length is about 16 times fiber optic radius (RFos) and height is about 2RFos. The eye contains fiber optics in the center surrounded by an elongated resin pocket. Embedding FOS causes geometric distortion of the reinforcing fiber over a height equal to 6 to 8 RFos. This defect causes severe stress concentration at the root of the resin pocket, the interface (in the composite) between the optical fiber and the composite, and at 90° to load direction in the composite. The… More >

  • Open Access

    ARTICLE

    Bone and Joints Modelling with Individualized Geometric and Mechanical Properties Derived from Medical Images

    M.C. Ho Ba Tho1

    CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 489-496, 2003, DOI:10.3970/cmes.2003.004.489

    Abstract The objective of the paper is to address the methodology developed to model bone and joints with individualised geometric and material properties from medical image data. An atlas of mechanical properties of human bone has been investigated demonstrating individual differences. From these data, predictive relationships have been established between mechanical properties and quantitative data derived from measurements on medical images. Subsequently, geometric and numerical models of bones with individualised geometrical and mechanical properties have been developed from the same source of image data. The advantages of this modelling technique are its ability to study the More >

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