K. Dinesh Babu^1,*, C. Senthil Singh²

Computer Systems Science and Engineering, Vol.44, No.1, pp. 709-720, 2023, DOI:10.32604/csse.2023.024295

Abstract Brain tumors are potentially fatal presence of cancer cells over a human brain, and they need to be segmented for accurate and reliable planning of diagnosis. Segmentation process must be carried out in different regions based on which the stages of cancer can be accurately derived. Glioma patients exhibit a different level of challenge in terms of cancer or tumors detection as the Magnetic Resonance Imaging (MRI) images possess varying sizes, shapes, positions, and modalities. The scanner used for sensing the location of tumors cells will be subjected to additional protocols and measures for accuracy, in turn, increasing the time… More >

XIANGCAI YANG¹, JIAGUI QU², JIEJING LI^1,*

BIOCELL, Vol.46, No.4, pp. 1041-1051, 2022, DOI:10.32604/biocell.2022.017383

Abstract Malignant glioma is one of the most common and deadly tumors in the central nervous system while developing effective treatments for this devastating disease remains a challenge. Previously, we demonstrated that the vitamin nicotinic acid (NA) inhibits glioma invasion. Here, we show that high-dose NA induces apoptosis of malignant glioma cells in vitro and in vivo. In cultured U251 glioma cells treated with NA, we detected ER stress that was likely caused by elevated intracellular calcium levels. The elevated calcium can be attributed to the activation of TRPV1, a cation channel that has been implicated in cutaneous flushing caused by… More >

F. Castinetti, A. Barlier, F. Sebag, D. Taieb

Oncologie, Vol.21, No.2, pp. 105-111, 2019, DOI:10.3166/onco-2019-0050

Abstract Pheochromocytoma and paraganglioma are tumors leading to increased morbidity and mortality. Over the last 20 years, several major advances allowed a better characterization of these tumors, either from an imaging or from a genetic viewpoint. This is especially the case for the hereditary characteristics of these tumors, as roughly 20 new genes have been identified. This is why the initial steps of the management of a pheochromocytoma and/or a paraganglioma now require a dedicated tertiary referral center. The aim of this review is to depict the diagnostic steps of these tumors, so as to allow the clinician to determine the… More >

Ozlem OZ^*

Oncologie, Vol.22, No.3, pp. 155-160, 2020, DOI:10.32604/oncologie.2020.014087

Abstract Neurofibromatosis type 1 is an autosomal dominant disorder which is characterized by multiple café-au-lait spots in the body, intertriginous freckles, Lisch nodules, neurofibroma, optic glioma and bone dysplasia. One of the clinical characteristics of Neurofibromatosis type 1 is the risk of benign and malignant tumor development. Optic gliomas, a type of astrocytoma, are the most common central nervous system complication in children with Neurofibromatosis type 1 and are seen in 10–15% of cases. In this case report, a patient with an optic glioma and a mutation that was not previously identified in the NF1 gene is presented in the light… More >

Mi Kyoung Song¹, Gi Beom Kim¹, Eun Jung Bae¹, Young Ah Lee¹, Hyun-Young Kim², Seung-Kee Min³, Jung Hee Kim⁴, Jae-Kyung Won⁵

Congenital Heart Disease, Vol.13, No.4, pp. 608-616, 2018, DOI:10.1111/chd.12625

Abstract Objective: Pheochromocytoma and paraganglioma (extra-adrenal pheochromocytoma) are rare neuroendocrine tumors that arise from the neuroendocrine cells. Chronic hypoxia is known as a possible cause, and a strong link between cyanotic congenital heart disease and these tumors has been reported. However, reports of phechromocytoma/paraganglioma in Fontan patients were scarce. We herein report seven cases of phechromocytoma/paraganglioma after Fontan operation at a single tertiary center.
Methods: We retrospectively reviewed medical records and imaging studies who diagnosed as phechromocytoma/paraganglioma after Fontan operation in Seoul National University Children’s Hospital.
Results: Seven patients were identified during follow-up after Fontan operation, and the prevalence was 2.5%… More >

Ravi Samikannu^{1, *}, Rohini Ravi², Sivaram Murugan³, Bakary Diarra⁴

CMC-Computers, Materials & Continua, Vol.63, No.3, pp. 1133-1142, 2020, DOI:10.32604/cmc.2020.08578

Abstract The identification of brain tumors is multifarious work for the separation of the similar intensity pixels from their surrounding neighbours. The detection of tumors is performed with the help of automatic computing technique as presented in the proposed work. The non-active cells in brain region are known to be benign and they will never cause the death of the patient. These non-active cells follow a uniform pattern in brain and have lower density than the surrounding pixels. The Magnetic Resonance (MR) image contrast is improved by the cost map construction technique. The deep learning algorithm for differentiating the normal brain… More >

Hong TIAN^{1, 2}, Peiyu CONG³, Ruiqun QI⁴, Xinghua GAO⁵, Xin LIU⁶, Hongsheng LIU⁷, Fengping SHAN^1,*

BIOCELL, Vol.41, No.1, pp. 27-32, 2017, DOI:10.32604/biocell.2017.41.027

Abstract Glioma is one of the lethal central nervous system tumors. The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues, resulting in inevitable recurrence after surgery operation. Gliomas do not metastasize, so to prevent the residual tumor from proliferating or invading is a key challenge. Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’ activities. Using a hypotaurine synthesis deficient U251 cell line, we proved that the cells invasion ability was impaired. Gene expression profile analysis exhibited that knocking down one of the key enzymes of hypotaurine synthesis,… More >

Ji SHI; Peixin SUN, Ye ZHANG, Bing YAO, Haozhe PIAO

BIOCELL, Vol.43, No.3, pp. 119-128, 2019, DOI:10.32604/biocell.2019.07577

Abstract Glioma is the most common primary malignant brain tumor with a poor survival rate. In recent years, no significant progress has been made in the treatment of gliomas in contrast to the development of improved diagnosis via molecular typing. Newcastle disease virus (NDV), a negative-stranded RNA virus that exhibits oncolytic activity, has been investigated for its capacity to elicit antitumor activity in many types of cancers, including glioma. Therefore, application of oncolytic viruses, such as NDV, as a new treatment strategy to specifically target aberrant signaling in glioblastomas has brought new hope. For many years, NDV has been investigated for… More >