Derrick Tsang1, Ioannis Loufopoulos2, Konstantinos Kapriniotis1,*, Hannah Danbury2, Ioannis Manolitsis3, Stamatios Katsimperis3, Senol Tonyali4, Patrick Juliebø-Jones5, Lazaros Tzelves2, Neha Sihra6, James Green1
Canadian Journal of Urology, Vol.33, No.4, pp. 771-782, 2026, DOI:10.32604/cju.2026.075625
- 21 August 2026
Abstract Ketamine is a potent anaesthetic drug that has been used for decades. Ketamine abuse is an increasingly common problem, particularly among young people. Over one quarter of ketamine users will have at least one bothersome urological symptom, with heavier and longer use leading to potentially irreversible damage to the lower and upper urinary tract. Hence, this study carried out a narrative review focusing on ketamine-induced uropathy pathophysiology, clinical presentation, and treatment options. It was found that ketamine uropathy is an inflammatory condition affecting predominantly the bladder but also the upper urinary tracts. A hypersensitivity reaction… More >