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  • Open Access

    ARTICLE

    Cytotoxicity Thresholds and Limited Modulation of LPS-Induced Microglial Activation by Croatian Olive Leaf Extracts: A Preliminary Study in a BV-2 Washout Model

    Kristina Pilipović1,*, Lucia Fabijančić2, Iva Kristić1, Lara Saftić Martinović3

    BIOCELL, Vol.50, No.9, 2026, DOI:10.32604/biocell.2026.079918 - 26 August 2026

    Abstract Objectives: Neuroinflammation, largely mediated by microglial activation, plays a central role in the pathogenesis of neurodegenerative diseases. In this study, we aimed to evaluate olive leaf extracts (OLEs) from three Croatian cultivars (Buža, Oblica, and Leccino) in the context of lipopolysaccharide (LPS)-induced activation of BV-2 microglia. Methods: Extracts were prepared by aqueous maceration and ethanol extraction under conditions compatible with downstream cell-culture use. Total phenolic and flavonoid contents were determined for both extract types, alongside targeted liquid chromatography–mass spectrometry (LC–MS/MS) quantification of major phenolic compounds. Based on compositional analysis, ethanolic extracts were selected for further evaluation,… More >

  • Open Access

    ARTICLE

    A Study on the Fatigue Failure Characteristics of Steel Bridge Deck Pavement Layers under Dynamic Loads

    Jiyi Li1, Zongqi Xiong2, Xinxin Cao3,*

    Structural Durability & Health Monitoring, Vol.20, No.5, 2026, DOI:10.32604/sdhm.2026.083367 - 24 August 2026

    Abstract In response to the common interlaminar shear and delamination defects in the pavement of long-span steel bridges, this paper investigates the interface fatigue failure mechanism of the “SMA-13 + epoxy resin + orthotropic steel plate” system. Static direct shear tests indicate that the optimal application rate of epoxy resin is 1.5 kg/m2, and that elevated temperatures cause the failure mode to transition from brittle fracture to ductile creep. Based on full-factorial dynamic shear fatigue tests, this study discarded subjective empirical thresholds and innovatively proposed the “geometric tangent method” to quantitatively define fatigue life. Analysis of variance More >

  • Open Access

    ARTICLE

    Contact Friction Behavior Analysis of Spherical Hinges in Swing Bridges Using Finite Element and Meta-Modeling

    Jiahao Wang1, Yuanxun Zheng1,*, Chaowei Du1, Shuaijie Zhang2, Xiangyang Chen3, Xiaojun Che4, Fuhua Wang5

    Structural Durability & Health Monitoring, Vol.20, No.5, 2026, DOI:10.32604/sdhm.2026.080081 - 24 August 2026

    Abstract Spherical hinges are critical load-bearing components in swing bridges, yet their complex contact friction behavior remains insufficiently investigated due to material and contact nonlinearities. Conventional parametric analysis based solely on finite element simulations suffers from low computational efficiency and limited consideration of multi-parameter coupling. In this study, a refined finite element model of an actual multi-lane swing bridge is established, and a support vector regression (SVR) metamodel is developed to efficiently predict contact stress distribution and frictional moments. Compared with existing studies that focus on single-factor parametric analysis, this work introduces a high-accuracy metamodel framework… More >

  • Open Access

    ARTICLE

    Clinical spectrum of retroperitoneal Castleman disease: retrospective analysis of 59 cases in a single Chinese medical center

    Ting Zhu1,2,#, Junjie Tian3,#, Chuan Wang2, Zhishang Li2, Yanfeng Bai4, Shien Rao2, Ping Wang1,*

    Canadian Journal of Urology, Vol.33, No.4, pp. 977-987, 2026, DOI:10.32604/cju.2026.077709 - 21 August 2026

    Abstract Backgrounds: Castleman disease (CD) is a rare lymphoproliferative disorder. While its general clinical and pathological features are well-described, detailed data on retroperitoneal CD—a diagnostically challenging location—remain scarce. This study characterizes the clinicopathological profile, management, and long-term outcomes of retroperitoneal CD. The aim of this study is to clarify the clinical and therapeutic characteristics of retroperitoneal CD, and to provide practical evidence for its accurate diagnosis and individualized management in clinical practice. Methods: A retrospective analysis of 59 patients with pathologically confirmed retroperitoneal CD (September 2010–December 2025) was conducted at a single center. Patients were classified… More >

  • Open Access

    REVIEW

    Ketamine uropathy: an update on pathophysiology, complications, and treatment options

    Derrick Tsang1, Ioannis Loufopoulos2, Konstantinos Kapriniotis1,*, Hannah Danbury2, Ioannis Manolitsis3, Stamatios Katsimperis3, Senol Tonyali4, Patrick Juliebø-Jones5, Lazaros Tzelves2, Neha Sihra6, James Green1

    Canadian Journal of Urology, Vol.33, No.4, pp. 771-782, 2026, DOI:10.32604/cju.2026.075625 - 21 August 2026

    Abstract Ketamine is a potent anaesthetic drug that has been used for decades. Ketamine abuse is an increasingly common problem, particularly among young people. Over one quarter of ketamine users will have at least one bothersome urological symptom, with heavier and longer use leading to potentially irreversible damage to the lower and upper urinary tract. Hence, this study carried out a narrative review focusing on ketamine-induced uropathy pathophysiology, clinical presentation, and treatment options. It was found that ketamine uropathy is an inflammatory condition affecting predominantly the bladder but also the upper urinary tracts. A hypersensitivity reaction… More >

  • Open Access

    ARTICLE

    Privacy-Preserving Collaborative Task Allocation for Multi-Skill Mobile Crowdsensing

    Jie Li, Fuyuan Song*, Qin Jiang

    CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.085946 - 13 August 2026

    Abstract Mobile crowdsensing enables large-scale sensing tasks through smart devices carried by users and has been widely applied in intelligent transportation and environmental monitoring. With the increasing complexity of sensing tasks, many tasks require the collaboration of multiple workers with different skills. However, both task-required skills and worker skills are privacy-sensitive, and directly exposing them to the platform may reveal task intentions and workers’ capability profiles. To address this issue, this paper proposes Dual-Fog Privacy-Preserving Multi-skill Task Allocation (DPMTA), a privacy-preserving task allocation scheme for multi-skill collaborative tasks. DPMTA adopts a dual-fog architecture to separately protect… More >

  • Open Access

    ARTICLE

    Parametric Characteristics Analysis of Three-Unit-Cell Model in 3D Seven-Directional Braided Composites

    Xiyue Zhang1, Feizhou Li1,*, Zhihai Hu1, Weiliang Zhang1, Xindang He2, Gexia Yuan1, Yanwei Feng3, Yafeng Qi4,5,*

    CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.084077 - 13 August 2026

    Abstract Three-dimensional (3D) braided composites are widely used in aerospace and automotive industries due to their superior mechanical properties. However, traditional 3D four-directional or five-directional braided composites exhibit limitations in multi-axial load-bearing capacity and structural stability under complex stress conditions. To address these challenges, we propose a novel 3D seven-directional braided composite structure, which enhances mechanical performance in both axial and transverse directions by incorporating additional reinforcement yarns. This structure consists of braiding yarns, axial yarns, six-directional yarns and seven-directional yarns, forming a more uniform and stable interlacing network. Based on the positional relationships between yarns, More >

  • Open Access

    ARTICLE

    DDE-SER: A Dual-Decomposition Ensemble Framework Fusing Adaptive Variational Modes and Harmonic-Percussive Spectrograms for Speech Emotion Recognition

    David Hason Rudd1,*, Cesar Sanin2, Md Rafiqul Islam3, Xianzhi Wang1, Huan Huo1

    CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.084015 - 13 August 2026

    Abstract The accurate classification of human emotions from speech remains a formidable challenge due to the dynamic, non-stationary properties of audio signals and pervasive background noise. Traditional single-domain extraction methods frequently fail to capture overlapping acoustic phenomena, resulting in high misclassification rates among acoustically similar emotions. To overcome this, we propose the Dual-Decomposition Ensemble (DDE-SER), an architecture that synergizes 1D adaptive frequency filtering with 2D spatial spectrogram separation. The framework operates through two distinct pipelines: an adaptive time-domain branch that leverages VGG-optiVMD to autonomously extract Intrinsic Mode Functions (IMFs), and a structural spectrogram branch that applies… More >

  • Open Access

    ARTICLE

    HAR-MLP: A Hybrid Attention–Residual MLP Architecture with Handcrafted Features for Software Bug Prediction

    Isil Karabey Aksakalli*

    CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.083166 - 13 August 2026

    Abstract Open-source platforms and issue tracking systems such as GitHub and Jira generate large volumes of issue reports and code changes, making effective bug identification a challenging task. This study investigates software bug prediction by integrating various feature extraction methods, including Word2Vec, TF-IDF, FastText, GloVe, and Doc2Vec, with several lightweight ML algorithms. Hybrid feature sets are further enhanced using Discrete Cosine Transform (DCT) and Discrete Wavelet Transform (DWT) and empirical results indicate that Word2Vec and Multi-Layer Perceptron (MLP) provide comparatively stronger performance. The study proposes a Hybrid Attention-Residual Multilayer Perceptron (HAR-MLP) model to automatically classify software… More >

  • Open Access

    ARTICLE

    Concordant Shared Transcriptomic Signatures and Candidate Regulatory Features in Chronic Lymphocytic Leukemia and Multiple Myeloma

    Abtin Tondar1,2,*, David Hervás Marín3, Laura Calvet Liñán4, Asim Kumar Bepari5

    Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.082424 - 13 August 2026

    Abstract Background: Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are B-cell malignancies with distinct cellular origins and microenvironmental dependencies. We aimed to identify concordant transcriptomic signatures and candidate transcriptional regulatory features between CLL CD19-positive B cells and MM-associated bone marrow-derived mesenchymal stromal cells (MSCs). Methods: Public Gene Expression Omnibus bulk RNA sequencing datasets were analyzed separately within each context using DESeq2. Differentially expressed genes (DEGs) were defined using adjusted p-value < 0.05 and absolute log2 fold change > 1. Cross-disease analyses assessed overlap, directionality, log2 fold-change concordance, expressed-gene background-adjusted enrichment, coexpression structure, and transcription factor annotation. Results: We… More >

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