Zhi-jian Meng^*, Ke Tao^†

Oncology Research, Vol.23, No.1-2, pp. 35-41, 2015, DOI:10.3727/096504015X14452563486057

Abstract Reports show that the stathmin gene may have a close relationship with tumor chemotherapeutic sensitivity. However, the effect of stathmin-1 on the chemosensitivity of gastric cancer to docetaxel has not been clearly determined. siRNA targeting stathmin-1 was introduced. The cell growth inhibition, expression of associated proteins, cell cycle, and apoptosis were evaluated by MTT, Western blot, and flow cytometric assays, respectively. The influence of silencing stathmin-1 was detected in situ and in vivo. SGC7901/docetaxel cells are the drug-resistant cells. After silencing stathmin-1, the resistance index (RI) reduced to 3.41, the expressions of STMN-1, MDR1, and More >

Akpofure E. Taigbenu¹

CMES-Computer Modeling in Engineering & Sciences, Vol.102, No.4, pp. 271-289, 2014, DOI:10.3970/cmes.2014.102.271

Abstract The solutions to inverse heat conduction problems (IHCPs) are provided in this paper by the Green element method (GEM), incorporating the logarithmic fundamental solution of the Laplace operator (Formulation 1) and the timedependent fundamental solution of the diffusion differential operator (Formulation 2). The IHCPs addressed relate to transient problems of the recovery of the temperature, heat flux and heat source in 2-D homogeneous domains. For each formulation, the global coefficient matrix is over-determined and ill-conditioned, requiring a solution strategy that involves the least square method with matrix decomposition by the singular value decomposition (SVD) method, More >

Hawa Singh¹, Paras Ram², Vikas Kumar³

FDMP-Fluid Dynamics & Materials Processing, Vol.10, No.4, pp. 521-550, 2014, DOI:10.3970/fdmp.2014.010.521

Abstract The fluctuating flow produced by magneto - hydrodynamic free convection past an impulsively started isothermal vertical plate is studied taking into account the effects of radiation and viscous dissipation. By using the similarity transformation, the governing equations are transformed into dimensionless form and then the system of nonlinear partial differential equations is solved by a perturbation technique. The considered uniform magnetic field acts perpendicular to the plate, which absorbs the fluid with a given suction velocity. A comparison is made in velocity and temperature profiles for two particular cases of real and imaginary time dependent More >

Gnaneswara Reddy Machireddy¹

FDMP-Fluid Dynamics & Materials Processing, Vol.10, No.4, pp. 417-442, 2014, DOI:10.3970/fdmp.2014.010.417

Abstract This study deals with the investigation of the effects exerted by heat radiation and a first-order chemical reaction on the magnetohydrodynamics boundary layer slip flow which is established past a vertical permeable surface embedded in a porous medium (with uniform heat and mass flux). The heat equation includes the relevant terms, i.e. the viscous dissipation, radiative heat flux, Ohmic dissipation, and absorption of radiation. The mass transfer equation takes into account the effects related to the chemically reactive species. A classical model for optically thin media is used for studying the effect of radiation. The More >

K. Kakuda¹, K. Tochikubo¹, J. Toyotani¹

CMES-Computer Modeling in Engineering & Sciences, Vol.95, No.5, pp. 351-367, 2013, DOI:10.3970/cmes.2013.095.351

Abstract The application of a CPU/GPU-based particle method to dam-breaking incompressible viscous fluid flow problems is presented. The particle approach is based on the MPS (Moving Particle Semi-implicit) scheme using logarithmic weighting function to stabilize the spurious oscillatory solutions for solving the Poisson equation with respect to the pressure fields by using GPU-based SCG (Scaled Conjugate Gradient) method. The physics-based computer graphics for the results of three-dimensional simulation consist of the POV-Ray (Persistence of Vision Raytracer) rendering using marching cubes algorithm as polygonization. Numerical results demonstrate the workability and the validity of the present approach through More >

K. Kakuda¹, T. Nagashima¹, Y. Hayashi¹, S. Obara¹, J. Toyotani¹, S. Miura², N. Katsurada³, S. Higuchi³, S. Matsuda³

CMES-Computer Modeling in Engineering & Sciences, Vol.93, No.5, pp. 363-376, 2013, DOI:10.3970/cmes.2013.093.363

Abstract The application of a GPU-based particle method to three-dimensional incompressible viscous fluid flow problems is presented. The particle approach is based on the MPS (Moving Particle Semi-implicit) scheme using logarithmic weighting function to stabilize the spurious oscillatory solutions for solving the Poisson equation with respect to the pressure fields by using GPU-based SCG (Scaled Conjugate Gradient) method. Numerical results demonstrate the workability and the validity of the present approach through the dam-breaking flow problem and flow behavior in a liquid ring pump with rotating impeller blades. More >

C.K. Chao¹, A. Wikarta²

CMES-Computer Modeling in Engineering & Sciences, Vol.93, No.3, pp. 167-186, 2013, DOI:10.3970/cmes.2013.093.167

Abstract In this paper a crack interacting with tri-material composite under a remote uniform tensile load is solved in plane elasticity. An edge dislocation distribution along the prospective site of the crack together with the principle of superposition is used to model a crack. The resulting singular integral equation with logarithmic singular kernels for a line crack is then established. The singular integral equation is solved numerically by modeling a crack in place of several segments. Linear interpolation formulae with undetermined coefficients are applied to approximate the dislocation distribution along the elements, except at vicinity of More >

Kazuhiko Kakuda¹, Tsuyoki Nagashima¹, Yuki Hayashi¹, Shunsuke Obara¹, Jun Toyotani¹, Nobuya Katsurada², Shunji Higuchisup>2, Shohei Matsuda²

CMES-Computer Modeling in Engineering & Sciences, Vol.88, No.1, pp. 17-28, 2012, DOI:10.3970/cmes.2012.088.017

Abstract An acceleration of the particle-based incompressible fluid flow simulations on GPU using CUDA is presented. The particle method is based on the MPS (Moving Particle Semi-implicit) scheme using logarithmic-type weighting function to stabilize the spurious oscillatory solutions for the pressure fields which are governed by Poisson equation. The standard MPS scheme is widely utilized as a particle strategy for the free surface flow, the problem of moving boundary, multi-physics/multi-scale ones, and so forth. Numerical results demonstrate the workability and the validity of the present approach through dam-breaking flow problem. More >

Kazuhiko Kakuda¹, Shunsuke Obara¹, Jun Toyotani¹, Mitsuhiko Meguro¹, Masakazu Furuichi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.83, No.1, pp. 57-72, 2012, DOI:10.3970/cmes.2012.083.057

Abstract The application of a particle method to incompressible viscous fluid flow problem and its physics-based computer graphics are presented. The method is based on the MPS (Moving Particle Semi-implicit) scheme using logarithmic weighting function to stabilize the spurious oscillatory solutions for the pressure fields which are governed by Poisson equation. The physics-based computer graphics consist of the POV-Ray (Persistence of Vision Raytracer) rendering using marching cubes algorithm as polygonization. The standard MPS scheme is widely utilized as a particle strategy for the free surface flow, the problem of moving boundary, multi-physics/multi-scale ones, and so forth. More >

Adam P. Klausner¹, Corey M. Johnson¹, Aaron B. Stike¹, John E. Speich², Vikram Sabarwal³, Amy S. Miner¹, MaryEllen Cleary, Harry P. Koo¹, Paul H. Ratz³

Canadian Journal of Urology, Vol.18, No.2, pp. 5608-5614, 2011

Abstract Introduction: The purpose of this investigation was to determine whether prostaglandin E2 (PGE2) is produced by rabbit detrusor muscle that is free of urothelium, and to demonstrate that PGE2 is responsible for the generation of spontaneous rhythmic contractions (SRC).
Materials and Methods: A bioassay was conducted in which the contraction frequency of rabbit detrusor strips was compared before and after the addition of superfusate obtained from incubated sections of rabbit detrusor. Specificity of the response was assessed using SC-51089, a PGE2 (EP1) receptor antagonist. The effects on tension development were also tested in artery segments treated with… More >