Yifan Wang¹, Xishun Qiu¹, Chao Wu¹, Jiazhao Li¹, Chang Dai¹, Bowen Han¹, Jinhu Hu², Mingliang Ma^1,*, Ye-Tang Pan^2,*

Journal of Polymer Materials, Vol.43, No.1, 2026, DOI:10.32604/jpm.2026.076443 - 03 April 2026

Abstract Polyurea (PUA) is widely valued in protective coatings and structural reinforcement because of its impressive mechanical strength and resistance to corrosion. Its high flammability, together with the poor dispersion that often comes with simply blending in flame retardants, continues to limit its use in demanding environments. To overcome these issues, this study introduces a different approach. We grafted 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) onto the surface of a metal–organic framework (MOF) and then partially amino-functionalized the DOPO layer, ultimately creating an amino-modified DOPO–MOF hybrid. The introduced amino groups can directly react with the isocyanate (–NCO) groups in the… More >

Chae-Young Lee¹, Yun-Jung Choi^2,*

International Journal of Mental Health Promotion, Vol.28, No.3, 2026, DOI:10.32604/ijmhp.2026.077116 - 31 March 2026

Abstract Background: Adolescent suicide remains a pressing public health concern in South Korea and worldwide, ranking as one of the leading causes of death among youth. Identifying modifiable risk and protective factors is critical for prevention strategies. Physical activity has been suggested as one such factor due to its potential mental health benefits. This study aimed to examine whether associations between physical activity and suicidality differ by activity type and by stage of suicidal behavior, distinguishing suicidal ideation, planning, and attempts among Korean adolescents. Methods: This cross-sectional secondary analysis used data from the 20th Korea Youth Risk… More >

Jingfei Shi^#, Yi Ding^#, Hui Lu^*

BIOCELL, Vol.50, No.3, 2026, DOI:10.32604/biocell.2026.073956 - 23 March 2026

Abstract Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Soluble interleukin-2 receptor alpha (sIL-2Rα) has been implicated in MS pathogenesis, but its mechanisms remain unclear. This study investigates how sIL-2Rα exacerbates MS by modulating microglial activation and antibody-dependent cellular cytotoxicity (ADCC) in an experimental autoimmune encephalomyelitis (EAE) mouse model. Methods: Female C57BL/6J mice were induced with EAE and treated with sIL-2Rα. Clinical symptoms, histopathology, and molecular changes were analyzed. Microglial activation was assessed via immunohistochemistry, Western blot, and RNA sequencing. In vitro, ADCC-mediated oligodendrocyte injury was evaluated using More >

Denisse A. Gutierrez^*, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguilera^*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074945 - 23 March 2026

Abstract Objectives: Drug resistance is the major determinant of chemotherapy failure, leading to relapse and tumor progression, demonstrating the urgent need for novel antineoplastic drugs. This study aimed to evaluate the anticancer potential of two novel pyrazole derivatives, P3C.1 and P3C.2, and to elucidate their mechanism of action in cancer cells. Methods: The cytotoxicity of the compounds was evaluated across 27 different cancer cell lines via a nuclear staining assay. Subsequent flow cytometric and biochemical analyses were performed to assess reactive oxygen species (ROS) generation, apoptosis induction, mitochondrial integrity, and cell cycle progression. Additional studies included… More >

Yen-Pin Chen^1,2,3, Rathinasamy Baskaran⁴, Hema Sri Devi⁴, Chaouhan Hitesh Singh⁴, Yu-Jung Lin^4,5, Marthandam Asokan Shibu⁶, Wei-Wen Kuo⁷, Shih-Chieh Liao⁸, Ming-Cheng Chen⁹, Tso-Fu Wang¹⁰, Chi-Cheng Li¹¹, Tsung-Jung Ho¹², Tzu-Ching Shih¹³, Shinn-Zong Lin^14,15,16,*, Chih-Yang Huang^4,17,18,19,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073080 - 23 March 2026

Abstract Objective: MicroRNAs (miRNAs) are small, non-coding RNAs that play a key role in the development of chemoresistance in various cancer types, including colorectal cancer (CRC). In this study, we aimed to study the underlying mechanisms of miRNA in chemotherapy-resistant CRC. Methods: LoVo CRC cell line was exposed to oxaliplatin at an increased dose, and cells were cultured in the presence of oxaliplatin to develop LoVoOXR cells. Microarray and Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), western blot, and transwell assay were used to evaluate the chemoresistance in LoVo^OXR CRC cells. Results: Microarray and qRT-PCR analysis showed… More >

Xinyue Zhang¹, Yuxuan Zhao², Jeremy S. Smith³, Yuechun Wang⁴, Gabriela Mogos⁵, Ka Lok Man¹, Yutao Yue^6,7,8,9, Young-Ae Jung^10,*

CMC-Computers, Materials & Continua, Vol.87, No.2, 2026, DOI:10.32604/cmc.2026.075415 - 12 March 2026

Abstract Intelligent Transportation Systems (ITS) represent a cornerstone in modern traffic management, leveraging surveillance cameras as primary visual sensors to monitor road conditions. However, the fixed characteristics of public surveillance cameras, coupled with inherent image resolution limitations, pose significant challenges for Small Object Detection (SOD) in traffic surveillance. To address these challenges, this paper proposes Ghost-Attention YOLO (GA-YOLO), a lightweight model derived from YOLOv8 and specifically designed for traffic SOD. To enhance the attention of small targets and critical features, a novel channel-spatial attention mechanism, termed Small-object Extend Attention (SEA), is introduced. In addition, the original… More >

Soukaina Azil^1,2,*, Yassmine Louanjli², Noureddine Louanjli², Moncef Benkhalifa³, Bouchra Ghazi^1,4,5

Canadian Journal of Urology, Vol.33, No.1, pp. 51-62, 2026, DOI:10.32604/cju.2025.069420 - 28 February 2026

Abstract Mammalian fertilization involves the migration of spermatozoa through the female reproductive system. Early embryonic development is a consequence of several steps and signaling pathways being activated, as well as biochemical and morphological modifications of spermatozoa that enable them to penetrate the membrane of mature oocytes.
There are some crucial steps known to clearly explain the process of fertilization, starting with hyperactivation of spermatozoa, mutual recognition, and binding of gametes mediated by receptors located on the surface membranes of both gametes. The final step is followed by oocyte activation, which is primarily triggered via sperm-derived factors, inducing a More >

A. S. M. Masudur Rahman¹, Muhammad Zunair Zamir¹, Syed Sajid Ullah^2,*, Salman Khan², Maria Saman¹, Naqash Bahadar¹

Journal on Artificial Intelligence, Vol.8, pp. 119-136, 2026, DOI:10.32604/jai.2026.076274 - 24 February 2026

Abstract Vehicle detection plays a pivotal role in autonomous driving, traffic monitoring, and intelligent surveillance systems. While YOLOv8 offers strong real-time performance, its detection accuracy is often limited by insufficient feature stability and suboptimal multi-scale feature fusion in complex scenes. To address these issues, we propose an enhanced YOLOv8 framework that retains the original backbone and detection head for efficiency while introducing targeted improvements to the neck architecture. Specifically, the model incorporates an Exponential Moving Average (EMA) feature layer to stabilize learning through temporally smoothed feature representations, which reduces noise and enhances generalization, and integrates GhostConv… More >

Gwan Hee Han^1,2,#, Hee Yun^3,#, Joon-Yong Chung⁴, Jae-Hoon Kim^3,5,6, Hanbyoul Cho^3,5,6,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072105 - 24 February 2026

Abstract Objectives: Phosphodiesterase 1A (PDE1A) regulates intracellular cyclic nucleotide signaling and has been implicated in tumor progression, but its clinical relevance and functional role in epithelial ovarian cancer (EOC), particularly in relation to the response to platinum remain unclear. This study aimed to evaluate the clinical significance of PDE1A in EOG and to clarify its functional role in tumor progression and response to platinum-based chemotherapy. Methods: PDE1A mRNA and protein levels were analyzed using public databases, RNA sequencing, and immunohistochemistry. Correlations between PDE1A expression, clinicopathological features, and prognosis were assessed. Functional roles were investigated in ovarian… More >

Iara Santos¹, Joana Liberal^1,2, Paulo Teixeira^1,3,4, Diana Martins^1,2,5,6, Fernando Mendes^1,2,5,6,7,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070281 - 24 February 2026

Abstract Background: The Colorectal Cancer (CRC) pathogenesis and therapeutic efficacy are influenced by the gut microbiome, making it a promising biomarker for predicting treatment responses and adverse effects. This systematic review aims to outline the gut microbiome composition in individuals with CRC undergoing the same therapeutic regimen and evaluate interindividual microbiome profile variations to better understand how these differences may influence therapeutic outcomes. Methods: Key studies investigating the microbiome’s role in therapeutic approaches for CRC were searched in both PubMed and Cochrane databases on 12 and 22 March 2025, respectively. Eligible studies included free full-text English-language… More > Graphic Abstract