Jiarui Zhang¹, Gang Wang^2,*, Siyuan Tong¹

CMC-Computers, Materials & Continua, Vol.61, No.3, pp. 1091-1104, 2019, DOI:10.32604/cmc.2019.05907

Abstract Aiming at the problem of gate allocation of transit flights, a flight first service model is established. Under the constraints of maximizing the utilization rate of gates and minimizing the transit time, the idea of “first flight serving first” is used to allocate the first time, and then the hybrid algorithm of artificial fish swarm and simulated annealing is used to find the optimal solution. That means the fish swarm algorithm with the swallowing behavior is employed to find the optimal solution quickly, and the simulated annealing algorithm is used to obtain a global optimal… More >

Ying Li¹, Bin Xue², Wenxu Sun², Junhua Wu², Wenting Yu², Meng Qin², Wei Wang², Yi Cao^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 147-147, 2019, DOI:10.32604/mcb.2019.07027

Abstract A key challenge in biomaterials research is to produce synthetic hydrogels that can replicate the diverse mechanical properties of the naturally occurring tissues for various biomedical applications, including tissue engineering, stem cell and cancer research, cell therapy, and immunomodulation. However, currently, the methods that can be used to control the mechanical properties of hydrogels are very limited and are mainly focused only on the elasticity of hydrogels. In this work, combining single molecule force spectroscopy, protein engineering and theoretical modeling, we show that synthetic protein hydrogels with predictable mechanical properties can be rationally designed using… More >

Yang Wang¹, Shuang Ge¹, Junyang Huang¹, Ruolin Du¹, Tieying Yin¹, Guixue Wang^1,*, Yazhou Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 140-141, 2019, DOI:10.32604/mcb.2019.07300

Abstract Zonula occludens-1 (ZO-1) is a peripheral membrane protein belongs to the family of zona occludens proteins and plays an important role as a scaffold protein which cross-links and anchors tight junction (TJ) strand proteins, within the lipid bilayer, to the actin cytoskeleton^[1-2]. Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy junctions of endothelial cells, the functions of the tight junction were also affected. However, the role of ZO-1 before and after stent implantation has not been fully understood. In this study, the expression of ZO-1 were analyzed by… More >

Junyang Huang¹, Shuang Ge¹, Yang Wang¹, Ruolin Du¹, Yazhou Wang¹, Tieying Yin¹, Guixue Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 138-139, 2019, DOI:10.32604/mcb.2019.07305

Abstract Tight junctions are the most apical intercellular junctions of the lateral membrane in endothelial cells, regulating the paracellular material and energy exchange and maintain plasma membrane polarity. Occludin protein is one of the important proteins involved in endothelial tight junctions, and also closely related to the occurrence of atherosclerosis. Therefore, the study of occludin is valuable ^[1]. With the implantation of coronary stents, the integrity of the vascular endothelium is damaged and the local mechanical environment at the stent segment was changed ^[2]. The present study tried to explore the impact of mechanical stimulation after stent… More >

Zhongzheng Wang^1,2, Fei Tian³, Shaobai Wang³, Songtao Ai², Tsung-Yuan Tsai^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 116-117, 2019, DOI:10.32604/mcb.2019.07690

Abstract This article has no abstract. More >

Han Yu¹, Tal Geva², Rahul H. Rathod², Alexander Tang², Chun Yang³, Zheyang Wu³, Kristen L. Billiar⁴, Xueying Huang⁵, Dalin Tang^1,*,3

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 56-57, 2019, DOI:10.32604/mcb.2019.07257

Abstract Computational biomechanical models are widely used in cardiovascular research for better understanding of mechanisms governing disease development, quantitative diagnostic strategies and improved surgical designs with better outcome. Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricle (RV) failure. The current surgical approach, which includes pulmonary valve replacement/insertion (PVR), has yielded mixed results. An innovative PVR surgical approach was proposed using active contracting bands to help ventricle to contract and improve RV function measured by ejection fraction [1]. Muscle active contraction caused by sarcomere shortening leads to… More >

Biyue Liu^1,*, Dalin Tang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 25-26, 2019, DOI:10.32604/mcb.2019.06825

Abstract The blood flow and mass transport pattern of low-density lipoprotein (LDL) in a right coronary artery with two stenoses are studied. Computations were carried out under physiological conditions. Our results show a strong correlation between wall shear stress (WSS) and distribution patterns of LDL. More >

Han Yu¹, Pedro J. del Nido², Tal Geva³, Chun Yang⁴, Zheyang Wu⁴, Rahul H. Rathod³, Xueying Huang⁵, Kristen L. Billiar⁶, Dalin Tang^1,4,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 73-74, 2019, DOI:10.32604/mcb.2019.05837

Abstract Ventricle mechanical stress and strain calculations play an important role in cardiovascular investigations. Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricular (RV) failure. The current surgical approach, including pulmonary valve replacement(PVR), has yielded mixed results with some patients recover RV function after pulmonary valve insertion with or without concomitant RV remodeling surgery but some do not[Therrien, Siu and McLaughlin (2000);]. Cardiac magnetic resonance (CMR) data were collected from 6 healthy volunteers and 12 Tetralogy of Fallot (TOF) patients before PVR with consent obtained. 12 patients… More >

Yue Feng¹, Youjun Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 31-32, 2019, DOI:10.32604/mcb.2019.05713

Abstract Coronary atherosclerotic heart disease, or coronary heart disease for short, is a heart disease caused by atherosclerotic lesions of coronary arteries, resulting in stenosis, spasm and live obstruction, leading to myocardial ischemia, hypoxia and even necrosis, and is the most common type of organ lesions caused by atherosclerosis. Coronary computed tomograph angiography (CCTA) has been the most effective method for examining coronary heart disease, but this method can only be judged from the morphology. It has been shown that when the coronary stenosis rate is as high as 70%, only 32% of blood vessels can… More >

Fuyou Liang^1,*, Tianqi Wang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 25-26, 2019, DOI:10.32604/mcb.2019.05710

Abstract Hepatic venous pressure gradient (HVPG) measurement has been increasingly accepted as a useful means for indirectly measuring portal venous pressure in patients with portal hypertension (PHT) caused by chronic liver diseases. Despite the existence of numerous studies addressing the clinical utility of HVPG measurement, it is as yet unclear how the accuracy of measured HVPG as a surrogate of portal pressure gradient (PPG) is influenced by the pathological status of the hepatic circulation that not only changes with the progression of liver disease but also differs considerably among patients. In addition, it remains unclear whether… More >