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  • Open Access

    ARTICLE

    Soil Metagenomics: new challenges and biotechnological opportunities

    Hernández-León R, I Velázquez-Sepúlveda, MC Orozco-Mosqueda, G Santoyo

    Phyton-International Journal of Experimental Botany, Vol.79, pp. 133-139, 2010, DOI:10.32604/phyton.2010.79.133

    Abstract Soil is a complex system that includes a great number and diversity of microorganisms. Until recently, only a small percentage of the bioma was known and could be studied. Currently, it is possible to have a deeper knowledge of all that unknown genomic material with the development of new tools, like metagenomics. New molecules have been discovered with various biotechnological applications, and knowledge of the diverse microbiological interactions in several environments, some of them with extreme life conditions, is much higher. We analyze the most recent literature in the field of metagenomics in this study, More >

  • Open Access

    ARTICLE

    Cancer Cell(s) Cycle Sequencing Reveals Universal Mechanisms of Apoptosis

    R. M. Ardito Marretta*, F. Ales

    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 225-266, 2010, DOI:10.3970/mcb.2010.007.225

    Abstract In this paper, cell cycle in higher eukaryotes and their molecular networks signals both inG1/SandG2/Mtransitions are replicatedin silico. Biochemical kinetics, converted into a set of differential equations, and system control theory are employed to design multi-nested digital layers to simulate protein-to-protein activation and inhibition for cell cycle dynamics in the presence of damaged genomes. Sequencing and controlling the digital process of four micro-scale species networks (p53/Mdm2/DNA damage, p21mRNA/cyclin-CDK complex, CDK/CDC25/wee1/ SKP2/APC/CKI and apoptosis target genes system) not only allows the comprehension of the mechanisms of these molecule interactions but paves the way for unraveling the… More >

  • Open Access

    ARTICLE

    Novel neurotrophic factor secreted by amniotic epithelial cells

    SANKAR VENKATACHALAM, TAMILSELVI PALANIAPPAN, PREM KUMAR JAYAPAL, SRIDHARAN NEELAMEGAN, SRIDHAR SKYLAB RAJAN, VIJAYA PRAKASH KRISHNAN MUTHIAH

    BIOCELL, Vol.33, No.2, pp. 81-89, 2009, DOI:10.32604/biocell.2009.33.081

    Abstract By virtue of expressions of glial and neural surface markers and capability of neurotransmitter metabolism, amniotic epithelial cells are considered as candidate cell type for transplantation strategies to treat neurological disorders. Previously, we have reported neurotrophism exhibited by human amniotic epithelial cells when transplanted after spinal cord injury in bonnet monkeys. Amniotic epithelial cells were believed to secrete an “Epidermal Growth Factor (EGF) - like” factor and exact identification was not made. At this juncture, through the present study it was found that, chicken neural retinal cells when grown alone failed to survive and contrarily… More >

  • Open Access

    ARTICLE

    The use of sunflower transcription factors as biotechnological tools to improve yield and stress tolerance in crops

    Chan RL

    Phyton-International Journal of Experimental Botany, Vol.78, pp. 5-10, 2009, DOI:10.32604/phyton.2009.78.005

    Abstract Transcription factors (TFs) are proteins able to specifically recognize DNA sequences in the regulatory regions of their target genes. They bind these specific sequences, an event that leads to the activation or repression of whole signal transduction pathways. In plants about 1500 TFs were informatically identified; identification was mainly based in the presence of DNA-binding domains in the translated sequences. They were classified in families and subfamilies according to several features, including the conservation of the DNA binding domain, the genes structures and the functions they exert. Among transcription factors, several seem to be potential… More >

  • Open Access

    ARTICLE

    Wave Propagation in Porous Piezoelectric Media

    A. Chakraborty1

    CMES-Computer Modeling in Engineering & Sciences, Vol.40, No.2, pp. 105-132, 2009, DOI:10.3970/cmes.2009.040.105

    Abstract A mathematical model is presented in this work that describes the behavior of porous piezoelectric materials subjected to mechanical load and electric field. The model combines Biot's theory of poroelasticity and the classical theory of piezoelectric material wherein it is assumed that piezoelectric coupling exists only with the solid phase of the porous medium. This model is used to analyze the stress and electric wave generated in bone and porous Lead-Zirconate-Titanate (PZT) due to high frequency pulse loading. The governing partial differential equations are solved in the frequency domain by transforming them into a polynomial… More >

  • Open Access

    ARTICLE

    Review : Biochemical-molecular markers in unilateral ureteral obstruction

    WALTER MANUCHA

    BIOCELL, Vol.31, No.1, pp. 1-12, 2007, DOI:10.32604/biocell.2007.31.001

    Abstract Congenital obstructive nephropathy is the primary cause of end-stage renal disease in children. Rapid diagnosis and initiation of the treatment are vital to preserve function and/or to slow down renal injury. Obstructive uropathy effects -decline in the plasmatic renal flow and glomerular filtration rate, interstitial infiltrate of leukocytes, significant decrease of the urine concentration, loss of the capacity to concentrate urine as well as fibrosis and apoptosis- are a consequence of a variety of factors that work in complex ways and are still not fully understood. Mediators as angiotensin II, transforming growth factor-β (TGF-β) and… More >

  • Open Access

    ABSTRACT

    Supplement. 7 Workshop: Biology of Ampullariidae Facultative and obligate symbiotic associations of Pomacea canaliculata (Caenogastropoda, Ampullariidae)

    I.A. VEGA*, M.C. DAMBORENEA**, C. GAMARRA-LUQUES*, E. KOCH*, J.A. CUETO, A. CASTRO-VAZQUEZ*

    BIOCELL, Vol.30, Suppl.S, pp. 367-375, 2006

    Abstract This article has no abstract. More >

  • Open Access

    ABSTRACT

    Supplement. 5 Workshop: Biology of Ampullariidae An integrative view to structure, function, ontogeny and phylogenetical significance of the male genital system in Pomacea canaliculata (Caenogastropoda, Ampullariidae)

    C. GAMARRA-LUQUES, B.C. WINIK, I.A. VEGA, E.A. ALBRECHT, N.M. CATALAN, A. CASTRO-VAZQUEZ

    BIOCELL, Vol.30, Suppl.S, pp. 345-357, 2006

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Angiotensin II type 1 receptor A1166C GENE polymorphism and essential hypertension in San Luis

    ALICIA VIVIANA LAPIERRE, MARIA ELENA ARCE, JOSÉ RAUL LOPEZ, GLADYS MARÍA CIUFFO.

    BIOCELL, Vol.30, No.3, pp. 447-455, 2006, DOI:10.32604/biocell.2006.30.447

    Abstract Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. The A1166C polymorphism of the AT1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A1166C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence… More >

  • Open Access

    ARTICLE

    Changes in crossover distribution along a quadrivalent in a man carrier of a reciprocal translocation t(11;14)

    M.I. PIGOZZI, R.B. SCIURANO, A.J. SOLARI

    BIOCELL, Vol.29, No.2, pp. 195-203, 2005, DOI:10.32604/biocell.2005.29.195

    Abstract A testicular biopsy from an infertile man carrying a heterozygous chromosome translocation t(11;14) was studied with synaptonemal complex analysis and immunolocalization of the protein MLH1 for crossover detection. A full blockage of spermatogenesis at the spermatocyte stage was related to the presence of the translocation quadrivalents at pachytene. Only 2% of the quadrivalents showed full synapsis. Most of the spermatocytes showed asynaptic free ends that frequently mingled with the XY pair. The average number of crossovers per cell was diminished from a mean of 52.7 in controls to a mean of 48 in the patient. More >

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