Diane Damotte^1,3, Claire Goulvestre², Jeannine Charreire², Claude Carnaud¹

European Cytokine Network, Vol.14, No.1, pp. 52-59, 2003

Abstract Although adjuvants are essential for the initiation of experimental autoimmune diseases, their precise contribution to the pathological manifestations is still poorly understood. Experimental autoimmune thyroiditis (EAT) is interesting in that respect because it can be initiated with the help of two different adjuvants — Freund’s complete or LPS — which may initiate independent pathogenic pathways. In the present study, we have compared Freund’s-induced versus LPS-induced EAT with respect to their dependence upon CD8⁺ T cells, which are considered as major actors in the pathogenesis of thyroiditis. Our results reveal that whereas CD8+ T cells are mandatory More >

Agnieszka Wierzbowska, Tadeusz Robak, Agata Wrzesień-Kuś, Anna Krawczyńska, Ewa Lech-Marańda, Halina Urbańska-Ryś

European Cytokine Network, Vol.14, No.3, pp. 149-153, 2003

Abstract Angiogenesis plays an important role in the pathogenesis of acute leukemia, and vascular endothelial growth factor (VEGF) is a crucial, positive regulator of this process. The biological activity of VEGF is mediated by two different receptor tyrosine kinases: VEGFR-2 and VEGFR-1. The soluble form of VEGFR-1 is likely to be a negative regulator of VEGF availability, but the physiological role of sVEGFR-2 is still unclear. The plasma levels of sVEGFR-1 and sVEGFR-2 in patients with acute leukemia have not been investigated. We measured the plasma concentrations of VEGF and its two soluble receptors in 39… More >

Armen G Aprikian¹, Neil Fleshner², Adrian Langleben³, Jeffrey Hames⁴

Canadian Journal of Urology, Vol.10, No.5, pp. 1986-1994, 2003

Abstract Objectives: To provide context in oncology for the significance of the benefits and cost of combined androgen blockade (CAB) in the treatment of advanced prostate cancer.
Methods: Canadian drug costs for the survival benefit with CAB in advanced prostate cancer were compared with the costs of benefit with new treatments in advanced non-small-cell lung cancer (NSCLC), metastatic colorectal cancer, and metastatic breast cancer. Clinical toxicities were also compared.
Results: The survival benefit with CAB in advanced prostate cancer appears to be approximately 3 months. The survival benefit with the addition of vinorelbine to cisplatin for the treatment of… More >

Shafquat Meraj, Harris M. Nagler, Peter Homel, Daniel Shasha, Joseph R. Wagner

Canadian Journal of Urology, Vol.10, No.1, pp. 1743-1748, 2003

Abstract Objective: To determine if there is correlation between the size of radical prostatectomy specimens and perioperative complications including intraoperative blood loss.
Methods: One hundred twenty consecutive retropubic radical prostatectomy cases were retrospectively reviewed. Perioperative complications, intraoperative blood loss, pathologic stage, and size of the prostatectomy specimen were recorded. Logistic regression was used to determine whether variables such as age, PSA, and prostate weight are significant predictors of perioperative complications and intraoperative blood loss.
Results: The final analysis included a total of 117 cases. Significant complications were seen in 10 patients (8.5%). The median weight of the prostatectomy specimen… More >

A.L. Estebenet, P.R. Martín

BIOCELL, Vol.26, Suppl.S, pp. 83-89, 2002

Abstract This article has no abstract. More >

Gerhard Klimeck^1,2, Fabiano Oyafuso², Timothy B. Boykin³, R. Chris Bowen², Paul von Allmen⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.3, No.5, pp. 601-642, 2002, DOI:10.3970/cmes.2002.003.601

Abstract Material layers with a thickness of a few nanometers are common-place in today's semiconductor devices. Before long, device fabrication methods will reach a point at which the other two device dimensions are scaled down to few tens of nanometers. The total atom count in such deca-nano devices is reduced to a few million. Only a small finite number of "free'' electrons will operate such nano-scale devices due to quantized electron energies and electron charge. This work demonstrates that the simulation of electronic structure and electron transport on these length scales must not only be fundamentally… More >