Juan Lizandro Rodríguez‐Hernández¹, Fayna Rodríguez‐González², Marta Riaño‐Ruiz³, Efrén Martínez‐Quintana^1,4

Congenital Heart Disease, Vol.13, No.5, pp. 655-662, 2018, DOI:10.1111/chd.12620

Abstract Introduction: Hyperuricemia has been associated with cardiovascular risk factors but it remains controversial if uric acid is an independent predictor of cardiac mortality.
Methods: A total of 503 CHD patients (457 nonhypoxemic and 46 hypoxemic) and 772 control patients fulfilled inclusion criteria. Demographic, clinical, and analytical data [serum uric acid and 24h urine uric acid levels, N‐terminal pro‐B‐type natriuretic peptide (NT‐pro‐BNP), and C‐reactive‐protein (CRP) concentrations] were studied. Survivals curves to determine cardiac death and arterial thrombosis in CHD patients were also examined.
Results: Noncyanotic and cyanotic CHD patients had significant higher serum uric acid concentration (5.2 ± 1.5 vs 4.9 ± 1.3mg/dL,… More >

Sukru Gulluoglu^*†, Mesut Sahin^‡, Emre Can Tuysuz^†, Cumhur Kaan Yaltirik^§, Aysegul Kuskucu^*, Ferda Ozkan^¶, Fikrettin Sahin^†, Ugur Ture^§, Omer Faruk Bayrak^*

Oncology Research, Vol.25, No.7, pp. 1177-1188, 2017, DOI:10.3727/096504017X14874349473815

Abstract Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemotherapy and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. Leukemia inhibitory factor (LIF) has multiple functions in stem cell biology, the immune response, and cancer, and is potentially a key molecule that allows… More >

Yachao Zhang¹, Kazim R. Chohan^2,3, Steve K. Landas^3,4, Jay E. Reeder⁴, J.C. Trussell⁴

Canadian Journal of Urology, Vol.21, No.5, pp. 7475-7478, 2014

Abstract Introduction: In obstructive azoospermia, choosing a sperm retrieval method for intracytoplasmic sperm injection (ICSI) depends on the preference and expertise of both the urologist and the reproductive endocrinologist. Generally, a percutaneous epididymal sperm aspiration (PESA) is attempted first. Not uncommonly, multiple PESA's are necessary. This study utilizes a rat model to provide an understanding of sperm parameter and histological changes resulting from repetitive PESA procedures.
Materials and methods: A cohort of 30 male Wistar rats of reproductive age (68-73 days) was divided into three groups of 10 (G1-G3). All three groups underwent a left epididymal head… More >

Nebojsa Ladjevic^1,4, Otas Durutovic^2,4, Ivana Likic-Ladjevic⁴, Natasa Lalic³, Ana Mimic¹, Natasa Dencic¹, Svetlana Sreckovic¹, Zoran Dzamic², Milan Terzic⁴, Aleksandar Vuksanovic^2,4, Dragica Milenkovic-Petronic^2,4

Canadian Journal of Urology, Vol.20, No.6, pp. 7021-7027, 2013

Abstract Introduction: Inflammation plays a key role in the development of benign prostatic hyperplasia. Prostaglandin E2 (PGE2) is an important inflammation factor found in enlarged prostatic tissue that can be the main cause of inflammatory pain. The aim of this study was to investigate whether epidural anesthesia can block the negative effects of prostaglandin mediators during prostate surgery.
Materials and methods: The study included 60 patients who underwent open prostatectomy. All patients were randomly allocated to one of two study groups. The first group received general anesthesia and the second group a combination of general and epidural anesthesia.… More >

Angela Reynolds^∗,†, Kittisak Koombua^‡, Ramana M. Pidaparti^{†,‡, §}, Kevin R. Ward^†,¶

Molecular & Cellular Biomechanics, Vol.9, No.2, pp. 141-156, 2012, DOI:10.3970/mcb.2012.009.141

Abstract Better understanding of the acute/chronic inflammation in airways is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. Local lung inflammation is triggered by many mechanisms within the lung, including pathogens. In this study, a cellular automata based model (CA) for pulmonary inflammation that incorporates biophysical processes during inflammatory responses was developed. The developed CA results in three possible outcomes related to homeostasis (healing), persistent infection, and resolved infection with high inflammation (inflamed state). The results from the model are validated qualitatively against other existing computational More >

Shile Liang^†, Meghan Hoskins^†, Cheng Dong^‡

Molecular & Cellular Biomechanics, Vol.7, No.2, pp. 77-91, 2010, DOI:10.3970/mcb.2010.007.077

Abstract To complete the metastatic journey, cancer cells have to disseminate through the circulation and extravasate to distal organs. However, the extravasation process, by which tumor cells leave a blood vessel and invade the surrounding tissue from the microcirculation, remains poorly understood at the molecular level. In this study, tumor cell adhesion to the endothelium (EC) and subsequent extravasation were investigated under various flow conditions. Results have shown polymorphonuclear neutrophils (PMNs) facilitate melanoma cell adhesion to the EC and subsequent extravasation by a shear-rate dependent mechanism. Melanoma cell-PMN interactions are mediated by the binding between intercellular More >

James Namsupak, Travis Headley, Rocco A. Morabito, Stanley Zaslau, Stanley J. Kandzari

Canadian Journal of Urology, Vol.15, No.1, pp. 3917-3919, 2008

Abstract Encrusted cystitis is a rare chronic inflammatory condition of the bladder. The case of a male patient with dysuria and gross hematuria accompanied by the passage of stone fragments is presented. Multimodal therapy was undertaken. He was treated with Renacidin (citric acid mixture) irrigation as an inpatient. One month later, he underwent cystourethroscopy and was determined to have residual stone and fibrosis of the prostatic urethra. The patient was then treated with cystolitholapaxy and visual internal urethrotomy. This multimodal treatment resulted in resolution of his stone burden at follow-up. More >