Mingwen Bi¹, Hefei Chen^2,*, Zhenghong Yang^3,*

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 861-876, 2025, DOI:10.32604/cmc.2025.060517 - 26 March 2025

Abstract Entity relation extraction, a fundamental and essential task in natural language processing (NLP), has garnered significant attention over an extended period., aiming to extract the core of semantic knowledge from unstructured text, i.e., entities and the relations between them. At present, the main dilemma of Chinese entity relation extraction research lies in nested entities, relation overlap, and lack of entity relation interaction. This dilemma is particularly prominent in complex knowledge extraction tasks with high-density knowledge, imprecise syntactic structure, and lack of semantic roles. To address these challenges, this paper presents an innovative “character-level” Chinese part-of-speech… More >

AMJAD YOUSUF¹, NAJEEB ULLAH KHAN^2,*

Oncology Research, Vol.33, No.4, pp. 851-861, 2025, DOI:10.32604/or.2025.058956 - 19 March 2025

Abstract Breast cancer is a significant global concern, with limited effective treatment options. Therefore, therapies with high efficacy and low complications, unlike the existing chemotherapies, are urgently required. To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction. This review aims to investigate the efficacy of MDM2 inhibition in restoring TP53 activity in breast cancer cells, as evidenced by clinical studies, reviews, and trials. TP53 is a tumor suppressor and MDM2 facilitates proteasomal degradation of TP53. MDM2 and TP53 activity More > Graphic Abstract

Denis S. Ryabov¹, Igor V. Kosarev^2,3, Daxing Xiong⁴, Aleksey A. Kudreyko⁵, Sergey V. Dmitriev^2,6,*

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 3797-3820, 2025, DOI:10.32604/cmc.2025.062079 - 06 March 2025

Abstract Molecular dynamics (MD) is a powerful method widely used in materials science and solid-state physics. The accuracy of MD simulations depends on the quality of the interatomic potentials. In this work, a special class of exact solutions to the equations of motion of atoms in a body-centered cubic (bcc) lattice is analyzed. These solutions take the form of delocalized nonlinear vibrational modes (DNVMs) and can serve as an excellent test of the accuracy of the interatomic potentials used in MD modeling for bcc crystals. The accuracy of the potentials can be checked by comparing the… More >

Ruhul Amin¹, Md. Jamil Khan¹, Tonway Deb Nath¹, Md. Shamim Reza², Jungpil Shin^3,*

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 3907-3919, 2025, DOI:10.32604/cmc.2025.061645 - 06 March 2025

Abstract Heart disease includes a multiplicity of medical conditions that affect the structure, blood vessels, and general operation of the heart. Numerous researchers have made progress in correcting and predicting early heart disease, but more remains to be accomplished. The diagnostic accuracy of many current studies is inadequate due to the attempt to predict patients with heart disease using traditional approaches. By using data fusion from several regions of the country, we intend to increase the accuracy of heart disease prediction. A statistical approach that promotes insights triggered by feature interactions to reveal the intricate pattern… More >

Yunzhao Wu¹, Guanglin Sha¹, Qing Duan¹, Xinwei Cong¹, Lu Liu¹, Ning Zhou², Yingjie Zhou^3,*

Energy Engineering, Vol.122, No.3, pp. 1093-1112, 2025, DOI:10.32604/ee.2025.060349 - 07 March 2025

Abstract To enhance energy interaction among low-voltage stations (LVSs) and reduce the line loss of the distribution network, a novel operation mode of the micro-pumped storage system (mPSS) has been proposed based on the common reservoir. First, some operation modes of mPSS are analyzed, which include the separated reservoir mode (SRM) and common reservoir mode (CRM). Then, based on the SRM, and CRM, an energy mutual assistance control model between LVSs has been built to optimize energy loss. Finally, in the simulation, compared to the model without pumped storage in the LVS, the SRM and CLRM… More > Graphic Abstract

Leonardo Di G. Sigalotti^*, Carlos A. Vargas

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 2281-2337, 2025, DOI:10.32604/cmes.2025.060497 - 03 March 2025

Abstract The evaporation of micrometer and millimeter liquid drops, involving a liquid-to-vapor phase transition accompanied by mass and energy transfer through the liquid-vapor interface, is encountered in many natural and industrial processes as well as in numerous engineering applications. Therefore, understanding and predicting the dynamics of evaporating flows have become of primary importance. Recent efforts have been addressed using the method of Smoothed Particle Hydrodynamics (SPH), which has proven to be very efficient in correctly handling the intrinsic complexity introduced by the multiscale nature of the evaporation process. This paper aims to provide an overview of… More > Graphic Abstract

JUN-JIE YU, WAN-XI YANG^*

BIOCELL, Vol.49, No.1, pp. 93-107, 2025, DOI:10.32604/biocell.2024.058299 - 24 January 2025

Abstract Hedgehog (HH) signaling has been researched for decades and Hedgehog has 3 homologs: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). Dhh is the one involved in male gonad and germ cell development. The distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis development. The patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH signaling. Some results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with More > Graphic Abstract

Mukul Mishra¹, Deeba Khan², Sehbanul Islam^1,*

BIOCELL, Vol.49, No.1, pp. 127-147, 2025, DOI:10.32604/biocell.2025.058038 - 24 January 2025

Abstract The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their More >

Haoran Meng^1,2,3, Nianxun Li⁴, Xukui Shen², Hong Zhang², Tian Li^4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.1, pp. 161-178, 2025, DOI:10.32604/fdmp.2024.055389 - 24 January 2025

Abstract The pressure wave generated by an urban-rail vehicle when passing through a tunnel affects the comfort of passengers and may even cause damage to the train and related tunnel structures. Therefore, controlling the train speed in the tunnel is extremely important. In this study, this problem is investigated numerically in the framework of the standard k-ε two-equation turbulence model. In particular, an eight-car urban rail train passing through a tunnel at different speeds (140, 160, 180 and 200 km/h) is considered. The results show that the maximum aerodynamic drag of the head and tail cars is More >

JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG^*

Oncology Research, Vol.33, No.2, pp. 357-367, 2025, DOI:10.32604/or.2024.050878 - 16 January 2025

Abstract Objectives: Melanoma is a highly aggressive and metastatic form of cancer, and the role of exosomal microRNAs (miRNAs) in its progression remains largely unexplored. This study aimed to investigate the effects of melanoma cell-derived exosomal miR-424-5p on angiogenesis and its underlying mechanisms. Methods: Exosomes were isolated from melanoma cell lines A375 and A2058, and their effects on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were examined. The interaction between miR-424-5p and its target gene, large tumor suppressor kinase 2 (LATS2), was analyzed using luciferase reporter assays and functional experiments. In vivo,… More >