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  • Open Access

    ARTICLE

    Exosomes: Key tools for cancer liquid biopsy

    ISABELLA PANFOLI1,*, MAURIZIO BRUSCHI2, GIOVANNI CANDIANO2

    BIOCELL, Vol.46, No.10, pp. 2167-2176, 2022, DOI:10.32604/biocell.2022.020154 - 13 June 2022

    Abstract Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA, but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in signalling between the tumor microenvironment and the… More >

  • Open Access

    ARTICLE

    Study on a Gas Plunger Lift Model for Shale Gas Wells and Its Effective Application

    Peng Liu1, Man Chen1, Zhiguo He1, Wei Luo2,3,*, Shiyu Miao2,3

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.4, pp. 933-955, 2022, DOI:10.32604/fdmp.2022.019736 - 06 April 2022

    Abstract The problem of efficient gas lift for gas well annulus packers that rely on their own energy plungers is considered. The complex related gas-liquid problem is addressed in the frame of model where the gas inflow dynamics and liquid inflow dynamics of the considered shale gas wells are weakly coupled. On this basis, and with the aiding support of indoor simulation experimental data, a new gas plunger lift design taking into account liquid leakage is obtained. Finally, a dedicated software relying on this approach is developed and used to verify the reliability of the model More >

  • Open Access

    ARTICLE

    Stepwise Pyrolysis by LBCR Downstream to Enhance of Gasoline Fraction of Liquid Fuel from MMSW

    Indra Mamad Gandidi1,2,*, Edy Suryadi3, Efri Mardawati3, Dwi Rustam Kendarto3, Nugroho Agung Pambudi4,*

    Energy Engineering, Vol.119, No.3, pp. 1169-1178, 2022, DOI:10.32604/ee.2022.018821 - 31 March 2022

    Abstract Pyrolysis is one of the thermal cracking methods to convert hydrocarbon to liquid fuel. The quantity and quality of the process are dependent on several condition including temperature, reaction time, catalyst, and the type of reactor. Meanwhile, a gasoline fraction was maximum product to be considered in the pyrolisis process. Therefore, this study aims to increase the gasoline fraction in liquid fuel using stepwise pyrolysis with a long bed catalytic reactor downstream (LBCR). The LBCR downstream was equipped with the top and bottom outlet and the fed source was mixed municipal solid waste (MMSW). The… More >

  • Open Access

    ARTICLE

    A Mathematical Model of Heat Transfer in Problems of Pipeline Plugging Agent Freezing Induced by Liquid Nitrogen

    Yafei Li, Yanjun Liu*

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.3, pp. 775-788, 2022, DOI:10.32604/fdmp.2022.019810 - 22 February 2022

    Abstract A mathematical model for one-dimensional heat transfer in pipelines undergoing freezing induced by liquid nitrogen is elaborated. The basic premise of this technology is that the content within a pipeline is frozen to form a plug or two plugs at a position upstream and downstream from a location where work a modification or a repair must be executed. Based on the variable separation method, the present model aims to solve the related coupled heat conduction and moving-boundary phase change problem. An experiment with a 219 mm long pipe, where water was taken as the plugging More >

  • Open Access

    ARTICLE

    Visualization Detection of Solid–Liquid Two-Phase Flow in Filling Pipeline by Electrical Capacitance Tomography Technology

    Ningbo Jing1, Mingqiao Li1, Lang Liu2,*, Yutong Shen1, Peijiao Yang1, Xuebin Qin1

    CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.1, pp. 465-476, 2022, DOI:10.32604/cmes.2022.018965 - 24 January 2022

    Abstract During mine filling, the caking in the pipeline and the waste rock in the filling slurry may cause serious safety accidents such as pipe blocking or explosion. Therefore, the visualization of the inner mine filling of the solid–liquid two-phase flow in the pipeline is important. This paper proposes a method based on capacitance tomography for the visualization of the solid–liquid distribution on the section of a filling pipe. A feedback network is used for electrical capacitance tomography reconstruction. This reconstruction method uses radial basis function neural network fitting to determine the relationship between the capacitance… More >

  • Open Access

    ARTICLE

    Rapid Profiling and Characterization of the Multicomponents from the Root and Rhizome of Salvia miltiorrhiza by Ultra-High Performance Liquid Chromatography/Ion Mobility-Quadrupole Time-of-Flight Mass Spectrometry in Combination with Computational Peak Annotation Workflows

    Boxue Chen1,#, Hongda Wang1,#, Meiyu Liu1, Wandi Hu1, Yuexin Qian1, Jiali Wang1, Jie Liu1, Xue Li1, Jing Wang2, Wenzhi Yang1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 1073-1088, 2022, DOI:10.32604/phyton.2022.019399 - 24 January 2022

    Abstract Herbal components characterization represents a challenging task because of the co-existing of multiple classes of naturally occurring compounds with wide spans of polarity, molecular mass, and the ubiquitous isomerism. The root and rhizome of Salvia miltiorrhiza have been utilized as a reputable traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Dan-Shen) in the treatment of cardiovascular disease. Herein, a dimension-enhanced ultra-high performance liquid chromatography/ion mobility/quadrupole time-of-flight mass spectrometry approach in combination with intelligent peak annotation workflows was established aimed to rapidly characterize the multicomponents from S. miltiorrhiza. Due to the sufficient optimization, satisfactory chromatography separation was enabled… More >

  • Open Access

    ARTICLE

    Low-Cost Flexible Graphite Monopole Patch Antenna for Wireless Communication Applications

    Suwat Sakulchat1, Amnoiy Ruengwaree1,*, Voranuch Thongpool2, Watcharaphon Naktong3

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 6069-6088, 2022, DOI:10.32604/cmc.2022.024050 - 14 January 2022

    Abstract This research investigates a monopole patch antenna for Wi-Fi applications at 2.45 and 5.2 GHz, and WiMax at 3.5 GHz. A low-cost and flexible graphite sheet with good conductivity, base on graphite conductive powder and glue is used to create a radiator patch and ground plane. Instead of commercially available conductive inks or graphite sheets, we use our self-produced graphite liquid to create the graphite sheet because it is easy to produce and inexpensive. The antenna structure is formed using a low-cost and easy hand-screen printing approach that involved placing graphite liquid on a bendable… More >

  • Open Access

    ARTICLE

    Numerical Simulation of Proppant Dynamics in a Rough Inclined Fracture

    Tiankui Guo1,*, Zhilin Luo1, Shanbo Mou2, Ming Chen1, Yuanzhi Gong3, Jianhua Qin4

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.2, pp. 431-447, 2022, DOI:10.32604/fdmp.2022.017861 - 16 December 2021

    Abstract Although the dynamics of proppant (small ceramic balls used to prevent opened fractures from closing on the release of pressure) have been the subject of several numerical studies over recent years, large-scale inclined fractures exist in unconventional reservoirs for which relevant information is still missing. In the present study, this problem is investigated numerically considering the influence of several relevant factors such as the fracture roughness, inclination, the proppant particle size, the injection rate and the fluid viscosity. The results show that a rough wall enables the proppant to travel farther and cover larger areas. More >

  • Open Access

    ARTICLE

    Numerical Simulation of Liquid-Solid Coupling in Multi-Angle Fractures in Pressure-Sensitive Reservoirs

    Yueli Feng1,2, Yuetian Liu1,2,*, Xiaolong Mao1,2, Jian Chen1,2

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.2, pp. 371-393, 2022, DOI:10.32604/fdmp.2022.017534 - 16 December 2021

    Abstract This study clarifies the seepage characteristics of complex fractured pressure-sensitive reservoirs, and addresses a common technological problem, that is the alteration of the permeability degree of the reservoir bed (known to be responsible for changes in the direction and velocity of fluid flows between wells). On the basis of a new pressure-sensitive equation that considers the fracture directional pressure-sensitive effect, an oil-gas-water three-phase seepage mathematical model is introduced, which can be applied to pressure-sensitive, full-tensor permeability, ultralow-permeability reservoirs with fracture-induced anisotropy. Accordingly, numerical simulations are conducted to explore the seepage laws for ultralow-permeability reservoirs. The More >

  • Open Access

    ARTICLE

    The Effect of a Liquid Cover on the Thermal Performance of a Salinity Gradient Solar Pond: An Experimental Study

    Asaad H. Sayer1, Mohsin E. Al-Dokheily1, Hameed B. Mahood2,*, Haider M. Khadem1, Alasdair N. Campbell3

    Energy Engineering, Vol.119, No.1, pp. 17-34, 2022, DOI:10.32604/EE.2022.017715 - 22 November 2021

    Abstract Salinity Gradient Solar Ponds (SGSPs) offer the potential to capture and store solar energy for use in a range of domestic and industrial activities in regions with high solar insolation. However, the evaporation of water from these ponds is a significant problem that must be overcome for them to be deployed successfully. Thus, two ponds were constructed in the city of Nasiriya, Iraq. The two ponds were cylindrical with a diameter of 1.4 m and a total depth of 1.4 m. The water body in the two ponds was constructed with layer depths of 0.5,… More >

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