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  • Open Access

    ARTICLE

    MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

    Geqiong Xiao*, Qiong Wang*, Bo Li, Xiaohui Wu, Hui Liao*, Yili Ren*, Ning Ai†*

    Oncology Research, Vol.26, No.8, pp. 1183-1189, 2018, DOI:10.3727/096504018X15151495109394

    Abstract Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably enhanced the growth suppression More >

  • Open Access

    RETRACTION

    [ARTICLE WITHDRAWN] Downregulation of SRC Kinase Signaling Inhibitor 1 (SRCIN1) Expression by MicroRNA-32 Promotes Proliferation and Epithelial‐Mesenchymal Transition in Human Liver Cancer Cells

    Chen Ren, Liao Jin-Yao, Huang Jing, Chen Wen-Li, Ma Xiao-Jun, Luo Xiao-Dan

    Oncology Research, Vol.26, No.4, pp. 573-579, 2018, DOI:10.3727/096504017X14954923820137

    Abstract THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020 More >

  • Open Access

    ARTICLE

    miR-935 Promotes Liver Cancer Cell Proliferation and Migration by Targeting SOX7

    Xiaorui Liu*†1, Jingjing Li*1, Zujiang Yu*, Juan Li*, Ranran Sun*, Quancheng Kan

    Oncology Research, Vol.25, No.3, pp. 427-435, 2017, DOI:10.3727/096504016X14747300207374

    Abstract Hepatocellular carcinoma (HCC) is the most common cancer in the world. MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. Aberrant expression of microRNA-935 (miR-935) has been reported in cancer studies. However, its expression and mechanism in HCC remain unclear. In our study, we found that miR-935 was upregulated in liver cancer tissues and cells. Overexpression of miR-935 in liver cells promoted cell proliferation, tumorigenesis, and cell cycle progression, whereas inhibition of miR-935 reduced cell proliferation, tumorigenicity, and cell cycle progression. These… More >

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