Yuefeng Ma^*, Jie Feng^†, Xin Xing^‡, Bin Zhou^*, Shaomin Li^*, Wei Zhang^*, Jiantao Jiang^*, Jin Zhang^*, Zhe Qiao^*, Liangzhang Sun^*, Zhenchuan Ma^*, Ranran Kong^*

Oncology Research, Vol.24, No.1, pp. 9-15, 2016, DOI:10.3727/096504016X14570992647168

Abstract The ribosomal protein (RP)–p53 pathway has been shown to play a key role in apoptosis and senescence of cancer cells. miR-1908 is a newly found miRNA that was reported to have prognostic potential in melanoma. However, its role and mechanism in the progression of non-small cell lung cancer (NSCLC) are largely unknown. In this study, we found that expression of miR-1908 was significantly downregulated in human NSCLC cell lines, including SK-MES-1, A549, and NCI-H460. Then the role of miR-1908 in NSCLC cell proliferation was explored. The miR-1908 mimic was transfected into NSCLC cell lines, and… More >

Yifan Zhao^*†1, Longxiao Wang^*1, Qianyi Huang^*‡, Youqin Jiang^*, Jingdong Wang^*, Liyuan Zhang^‡§, Ye Tian^‡§, Hongying Yang^*§

Oncology Research, Vol.24, No.1, pp. 1-7, 2016, DOI:10.3727/096504016X14570992647087

Abstract Although medically inoperable patients with stage I non-small cell lung cancer cells (NSCLC) are often treated with stereotactic body radiation therapy, its efficacy can be compromised due to poor radiosensitivity of cancer cells. Inhibition of transforming growth factor-β1 (TGF-β1) using LY364947 and LY2109761 has been demonstrated to radiosensitize cancer cells such as breast cancer, glioblastoma, and lung cancer. Our previous results have demonstrated that another potent and selective inhibitor of TGF-β1 receptor kinases, SB431542, could radiosensitize H460 cells both in vitro and in vivo. In the present study, we investigated whether SB431542 could radiosensitize other… More >

Yan Zhen^*1, Dongming Li^*†1, Wen Li^*, Weimin Yao^*†1, Aibing Wu^‡, Jing Huang^‡, Hongli Gu^*†, Yujie Huang^*†, Yajun Wang^*, Jun Wu^*†, Min Chen^*†, Dong Wu^*†, Quanchao Lyu^*, Weiyi Fang^§, Bin Wu^*†

Oncology Research, Vol.23, No.1-2, pp. 61-68, 2015, DOI:10.3727/096504015X14478843952861

Abstract It is largely recognized that PDCD4 is frequently lost in tumors of various origins, including lung cancer, and its loss contributes to tumor progression. However, its role and molecular mechanism remain largely unexplored in non-small cell lung cancer (NSCLC). In this study, downregulated PDCD4 mRNA expression was found in NSCLC tissues compared to their corresponding paracarcinoma tissues and distal paracarcinoma tissues. Induced expression of PDCD4 inhibited cell growth and proliferation and cell cycle transition in vitro. Conversely, knocking down PDCD4 expression promoted cell growth and proliferation. Mechanistically, PDCD4 inactivated PI3K/Akt signaling and its downstream cell More >

Feng Xi^*, Jianghao Ye^†

Oncology Research, Vol.23, No.1-2, pp. 53-59, 2015, DOI:10.3727/096504015X14459480491740

Abstract Hexokinase 2 (HK2) has been identified as an oncogene in some malignant diseases such as breast cancer and ovarian cancer. However, the role of HK2 in lung cancer remains unclear. In this study, we explored the functional role of HK2 in lung cancer cell proliferation and tumorigenesis and determine its expression profile in lung cancer. HK2 expression was increased in primary lung cancer tissues of patients. Knocking down HK2 expression by small interfering RNA (siRNA) inhibited cell proliferation in lung cancer cells and nude mice. Thus, HK2 is required for sustained proliferation and survival of More >

Fei Liu^*1, Bihua Lin^*1, Xin Liu^*, Wenzhang Zhang^*, Erying Zhang^*, Liang Hu^*, Yuefan Ma^*, Xiangyong Li^*, Xudong Tang^*†

Oncology Research, Vol.23, No.3, pp. 109-118, 2015, DOI:10.3727/096504015X14496932933610

Abstract Extracellular signal-regulated kinase (ERK)1/2 signaling pathway plays a critical role in regulating tumor angiogenesis. Our previous studies have demonstrated that HPV-16 oncoproteins enhanced hypoxia-inducible factor-1α (HIF-1α) protein accumulation and vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) expression in non-small cell lung cancer (NSCLC) cells, thus contributing to angiogenesis. In this study, we further investigated the role of ERK1/2 signaling pathway in HPV-16 oncoprotein-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in NSCLC cells. Our results showed that HPV-16 E6 and HPV-16 E7 oncoproteins promoted the activation of ERK1/2 signaling pathway in A549 More >

Si Jun Park^*1, Bo Ram Lee^*1, Hyeng-Soo Kim^*, Young Rae Ji^*, Yong Hun Sung^*, Kwang ShikChoi^*, Hum Dai Park^†, Sung-Hyun Kim^*, Myoung Ok Kim^‡, Zae Young Ryoo^*

Oncology Research, Vol.23, No.3, pp. 89-98, 2015, DOI:10.3727/096504015X14496932933539

Abstract In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of More >

Mustafa Sofikerim¹, İbrahim Gülmez¹, Fatma Tokat², Özlem Er³, İnci Gülmez⁴

Canadian Journal of Urology, Vol.14, No.4, pp. 3643-3645, 2007

Abstract We report a case of epidermoid-cell carcinoma of the lung that developed a metastatic lesion in the penis.A 50-year-old male patient was admitted to our hospital with bloody sputum and cough. He had a left pneumectomy and was diagnosed with epidermoid carcinoma of the lung at stage IIB (T2N1M0). He was started on an adjuvant chemotherapy protocol consisting of cisplatin and paclitaxel. He was admitted to our urology clinic with obstructive symptoms during urination and pain during penile erection.Physical examination revealed a firm, 3 cm x 2 cm palpable mass on the radix of his More >