Demirhan Örsan Demir^1,*, Yusuf Gökkurt¹, Salih Bürlükkara², Turgay Kaçan¹, Ali Kaan Yıldız¹, Ufuk Bozkurt², Tolga Karakan¹

Canadian Journal of Urology, Vol.32, No.2, pp. 111-118, 2025, DOI:10.32604/cju.2025.063970 - 30 April 2025

Abstract Introduction: Surgeons typically prefer 270 µm and 272 µm laser probes in retrograde intrarenal surgery (RIRS) due to the reduced deflection capacity of flexible ureterorenoscopes when using larger probe diameters. This study aims to investigate the effects of 272 and 365 µm holmium laser probes on operative time, clinical efficacy, and complication rates in RIRS. Materials and Methods: A total of 285 patients with proximal ureteral or kidney stones who met the inclusion criteria were enrolled in the study. Patients were divided into two groups based on laser probe thickness: 272 µm and 365 µm. Stone-free… More >

Mihály Murányi^1,*, András Domoszlai¹, Attila Csaba Nagy², Tibor Flaskó¹

Canadian Journal of Urology, Vol.32, No.2, pp. 119-127, 2025, DOI:10.32604/cju.2025.063821 - 30 April 2025

Abstract Introduction: We aimed to compare the oncological and functional outcomes of glansectomy and split-thickness skin graft reconstruction (GR) with those of glansectomy alone (GA) and penile amputation (PA). Materials and Methods: This retrospective study included patients with penile carcinoma or penile intraepithelial neoplasia diagnosed between 2017 and 2022. Surgical outcomes, complications, and oncological outcomes were assessed through a chart review, and functional outcomes were assessed using a questionnaire administered to patients who underwent GR (group A), GA (group B), or PA (group C). Results: Six, eight, and seven patients were enrolled in groups A, B, and… More >

Mark Shilling¹, Lauren S. Faber², Hoi Doan², Merry Peckham², Timothy R. Petersen^1,3, Reza Ehsanian¹, Frances Alba^2,*

Canadian Journal of Urology, Vol.32, No.2, pp. 81-88, 2025, DOI:10.32604/cju.2025.063415 - 30 April 2025

Abstract Introduction: Existing literature has highlighted disparities in acute pain management across racial and sex groups in both emergency department and pre-hospital settings. This study aimed to evaluate prescribing patterns among physicians and advanced practice providers for patients with upper tract urolithiasis in an academic emergency department. Materials and Methods: Retrospective chart review of patients diagnosed with upper tract urolithiasis was performed to evaluate age, sex, race, ethnicity, stone size and location, presence of hydronephrosis, admission status, history of prior nephrolithiasis, medications administered in the emergency department (ED), requests for urology consult or referral, and discharge medications. More >

Haohan Zhao¹, Xingchen Zhu², Wencan Li^3,*, Xin Lin^4,*

International Journal of Mental Health Promotion, Vol.27, No.4, pp. 517-540, 2025, DOI:10.32604/ijmhp.2025.062739 - 30 April 2025

Abstract Background: Despite increasing attention to parental educational anxiety in China’s educational system, the underlying mechanisms through which this anxiety affects adolescent academic performance remain unclear. This study aims to investigate how parental educational anxiety influences academic outcomes through depression and self-efficacy while considering the role of problematic social media use in today’s digital age. Methods: Data analysis was conducted using stratified random cluster sampling techniques. Participants for this study were recruited from middle and high schools in China. The sample comprised 2579 traditional two-parent families, each consisting of a pair of parents and one child.… More >

Gege Liu^#, Houfang Zhang^#, Yunhui Peng^*

BIOCELL, Vol.49, No.4, pp. 519-538, 2025, DOI:10.32604/biocell.2025.061470 - 30 April 2025

Abstract Nucleosomes play a vital role in chromatin organization and gene regulation, acting as key hubs that interact with various chromatin-associated factors through diverse binding mechanisms. Recent research has highlighted the prevalence of mutations in linker histones across different types of cancer, emphasizing their critical involvement in cancer progression. These cancer-associated mutations in linker histones have been shown to disrupt nucleosome stacking and the formation of higher-order chromatin structures, which in turn significantly affect epigenetic regulatory processes. In this review, we provide a comprehensive analysis of how cancer-associated linker histone mutations alter their physicochemical properties, influencing More >

Qing Wang, Luyao Cai, Shouyi Tang, Dan Pan, Zhen Wang, Qianming Chen, Yu Zhou^*, Yingqiang Shen^*

BIOCELL, Vol.49, No.4, pp. 579-605, 2025, DOI:10.32604/biocell.2025.060045 - 30 April 2025

Abstract Cancer Stem Cells (CSCs) are cancer cells with self-renewal and tumorigenesis abilities. CSCs in tumor tissues are the leading cause of tumor progression, recurrence, and drug resistance. CSCs have distinct metabolic features that contribute to maintaining their self-renewal and stemness. Phospholipids are essential components of cell membranes and play fundamental roles in cellular activities. CSCs have abnormal phospholipid metabolism, which affects their self-renewal, differentiation, invasion, and drug resistance. Compared with non-CSCs, the phospholipid metabolism of CSCs mainly focused on significantly increased fatty acid (FAs) and phospholipids synthesis, phospholipid unsaturation, and lipolysis-fatty acid oxidation (FAO). In More > Graphic Abstract

Ridha Djebali^1,*, Bernard Pateyron², Mokhtar Ferhi¹, Mohamed Ouerhani³, Karim Khemiri¹, Montassar Najari¹, M. Ammar Abbassi⁴, Chohdi Amri⁵, Ridha Ennetta⁶, Zied Driss⁷

Frontiers in Heat and Mass Transfer, Vol.23, No.2, pp. 441-461, 2025, DOI:10.32604/fhmt.2025.063375 - 25 April 2025

Abstract This paper investigates the application of Direct Current Atmospheric Plasma Spraying (DC-APS) as a versatile thermal spray technique for the application of coatings with tailored properties to various substrates. The process uses a high-speed, high-temperature plasma jet to melt and propel the feedstock powder particles, making it particularly useful for improving the performance and durability of components in renewable energy systems such as solar cells, wind turbines, and fuel cells. The integration of nanostructured alumina (Al₂O₃) thin films into multilayer coatings is considered a promising advancement that improves mechanical strength, thermal stability, and environmental resistance. The More >

XI ZHU^1,2,#, KAI HUANG^3,#, XIAOMING KAO², ZHAOHUI TANG³, WENJIE GUO³, TIANCONG WU^4,*, QIURONG LI^1,2,*

Oncology Research, Vol.33, No.5, pp. 1149-1159, 2025, DOI:10.32604/or.2024.054930 - 18 April 2025

Abstract Background: Colorectal cancer (CRC) holds the third position in global cancer prevalence mortality. Although chemotherapy is a conventional treatment, recent investigations have shed light on the therapeutic potential of the cGAS cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway in CRC management. Despite the primary role of the death domain-associated protein (Daxx) in cellular apoptosis, its influence on the regulation of cGAS-STING activation remains elusive. Methods: The Daxx degradation and speck formation were conducted using immunofluorescence and Western blotting. The Daxx knock-down and over-expression in CRC cells were performed to detect in vivo and in vitro… More >

Shabana Ziyad Puthu Vedu^1,*, Wafaa A. Ghonaim², Naglaa M. Mostafa³, Pradeep Kumar Singh⁴

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2599-2617, 2025, DOI:10.32604/cmc.2025.062695 - 16 April 2025

Abstract Hearing and Speech impairment can be congenital or acquired. Hearing and speech-impaired students often hesitate to pursue higher education in reputable institutions due to their challenges. However, the development of automated assistive learning tools within the educational field has empowered disabled students to pursue higher education in any field of study. Assistive learning devices enable students to access institutional resources and facilities fully. The proposed assistive learning and communication tool allows hearing and speech-impaired students to interact productively with their teachers and classmates. This tool converts the audio signals into sign language videos for the… More >

Vijaya Krishna Akula^1,*, Tan Kuan Tak², Pravin Ramdas Kshirsagar³, Shrikant Vijayrao Sonekar⁴, Gopichand Ginnela⁵

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2449-2479, 2025, DOI:10.32604/cmc.2025.061486 - 16 April 2025

Abstract The rapid expansion of Internet of Things (IoT) networks has introduced challenges in network management, primarily in maintaining energy efficiency and robust connectivity across an increasing array of devices. This paper introduces the Adaptive Blended Marine Predators Algorithm (AB-MPA), a novel optimization technique designed to enhance Quality of Service (QoS) in IoT systems by dynamically optimizing network configurations for improved energy efficiency and stability. Our results represent significant improvements in network performance metrics such as energy consumption, throughput, and operational stability, indicating that AB-MPA effectively addresses the pressing needs of modern IoT environments. Nodes are More >