Peirong Jiang¹, Zhensen Chen², Daniel S. Hippe², Hiroko Watase³, Bin Sun¹, Ruolan Lin¹, Zheting Yang¹, Yunjing Xue^1,*, Xihai Zhao^4,*, Chun Yuan^2,4

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 34-35, 2019, DOI:10.32604/mcb.2019.07394

Abstract This article has no abstract. More >

Lijian Xu^1,2, Lekang Yin³, Fuyou Liang^1,2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 71-72, 2019, DOI:10.32604/mcb.2019.05741

Abstract Recent studies have revealed that aortic valve diseases are associated with the increased incidence of the aortopathy development. However, the influence of aortic valve diseases on aortic hemodynamics remains unclear. The purpose of this study was therefore to investigate the hemodynamic differences in patients with and without aortic valve disease through patient-specific simulations performed on two aorta models (BAV with severe stenosis vs. normal tricuspid aortic valve (TAV)). Realistic geometries and boundary conditions were obtained from computed tomography angiography (CTA) and phase-contrast magnetic resonance imaging (PC-MRI) measurements, respectively. In addition, 4D-MRI were performed to validate the numerical methods used to… More >

Yongqiang Li^1,#, Changxin Lai^1,#, Chengchen Zhang², Alexa Singer¹, Suhao Qiu¹, Boming Sun², Michael S. Sacks³, Yuan Feng^1,*

Molecular & Cellular Biomechanics, Vol.16, No.4, pp. 245-251, 2019, DOI:10.32604/mcb.2019.07441

Abstract Surgeries such as implantation of deep brain stimulation devices require accurate placement of devices within the brain. Because placement affects performance, image guidance and robotic assistance techniques have been widely adopted. These methods require accurate prediction of brain deformation during and following implantation. In this study, a magnetic resonance (MR) image-based finite element (FE) model was proposed by using a coupled Eulerian-Lagrangian method. Anatomical accuracy was achieved by mapping image voxels directly to the volumetric mesh space. The potential utility was demonstrated by evaluating the effect of different surgical approaches on the deformation of the corpus callosum (CC) region. The… More >

Ali. E. Dabiri^1,2,*, Richard Leigh³, Ghassan S. Kassab¹

Molecular & Cellular Biomechanics, Vol.16, No.4, pp. 225-233, 2019, DOI:10.32604/mcb.2019.07962

Abstract Stroke is a life-threatening event that is expected to more than double over the next 40 years. Approximately 85% of strokes are ischemic in nature and result from thromboembolic occlusion of a major cerebral artery or its branches. One of the diagnostic methods for detection of the cerebral ischemia is the gadolinium-enhanced MRI imaging. It is mainly used in patients to detect brain tissue damaged by an ischemic stroke and brain hemorrhage. These techniques are expensive, require sophisticated machines and are time consuming. A recent study in acute stroke patients showed gadolinium leakage into ocular structures (GLOS) during MRI imaging… More >

Dalin Tang¹, Chun Yang², Satya Atluri³

The International Conference on Computational & Experimental Engineering and Sciences, Vol.18, No.3, pp. 67-68, 2011, DOI:10.3970/icces.2011.018.067

Abstract Cardiovascular disease is the leading cause of death worldwide. Many victims of the disease died suddenly without prior symptoms. It is a great challenge for clinicians and researchers to develop screening techniques and assessment methodologies to identify those patients for early treatment and prevention of the fatal clinical event. Considerable effort has been devoted investigating mechanisms governing atherosclerotic plaque progression and rupture [Friedman, Bargeron, Deters, Hutchins and Mark (1987); Friedman and Giddens (2005); Giddens, Zarins, Glagov, S. (1993); Ku, Giddens, Zarins and Glagov (1985); Gibson et al. (1993); Liu and Tang (2010); Stone et al. (2003); Yang, Tang, Atluri et… More >

Chein-Shan Liu¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.3, No.2, pp. 57-68, 2007, DOI:10.3970/icces.2007.003.057

Abstract A new method is developed to solve the interior and exterior Dirichlet problems for the two-dimensional Laplace equation, namely the meshless regularized integral equation method (MRIEM), which consists of three parts: Fourier series expansion, the second kind Fredholm integral equation and an analytically regularized solution of the unknown boundary condition on an artificial circle. We find that the new method is powerful even for the problem with very complex boundary shape and with boundary noise. More >

Mohammad Behrouzian Nejad¹, Mohammad Ebrahim Shiri Ahmadabadi^{1, 2, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.119, No.1, pp. 185-205, 2019, DOI:10.32604/cmes.2019.01838

Abstract The main target of this paper is presentation of an efficient method for MRI images classification so that it can be used to diagnose patients and non-patients. Image classification is one of the prominent subset topics of machine learning and data mining that the most important image technique is the auto-categorization of images. MRI images with high resolution and appropriate accuracy allow physicians to decide on the diagnosis of various diseases and treat them. The auto categorization of MRI images toward diagnosing brain diseases has been being used to accurately diagnose hospitals, clinics, physicians and medical research centers. In this… More >

Qingyu Wang¹, Dalin Tang^1,2,*, Gador Canton³, Zheyang Wu², Thomas S. Hatsukami⁴, Kristen L. Billiar⁵, Chun Yuan⁶

Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 189-201, 2018, DOI:10.32604/mcb.2018.04572

Abstract Cardiovascular diseases are closely linked to atherosclerotic plaque development and rupture. Assessment of plaque vulnerability is of fundamental significance to cardiovascular research and disease diagnosis, prevention, treatment and management. Magnetic resonance image (MRI) data of carotid atherosclerotic plaques from 8 patients (5 male, 3 female; age: 62-83, mean=71) were acquired at the University of Washington (UW), Seattle by the Vascular Imaging Laboratory (VIL) with written informed consent obtained. Patient-specific vessel material properties were quantified using Cine MRI data for modeling use. 3D thin-layer models were used to obtain plaque stress and strain for plaque assessment. A stress-based plaque vulnerability index… More >

Dalin Tang^1,*,2, Heng Zuo^2,*, Chun Yang², Zheyang Wu², Xueying Huang³, Rahul H. Rathod⁴, Alexander Tang⁴, Kristen L. Billiar⁵, Tal Geva⁴

Molecular & Cellular Biomechanics, Vol.14, No.3, pp. 137-151, 2017, DOI:10.3970/mcb.2017.014.137

Abstract Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricle failure. Comparing TOF patients with healthy people may provide information to address this challenge. Cardiac magnetic resonance (CMR) data were obtained from 16 TOF patients (patient group, PG) and 6 healthy volunteers (healthy group, HG). At begin-of-ejection, better patient group (n=5, BPG) stress was very close to HG stress (54.7±38.4 kPa vs. 51.2±55.7 kPa, p=0.6889) while worse patient group (n=11, WPG) stress was 84% higher than HG stress (p=0.0418). Stress may be used as an indicator to differentiate BPG patients from WPG… More >

Xueying Huang^*, Chun Yang^†, Chun Yuan^‡, Fei Liu^‡, Gador Canton^‡, Jie Zheng^§, Pamela K. Woodard^§, Gregorio A. Sicard^¶, Dalin Tang^||

Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 121-134, 2009, DOI:10.3970/mcb.2009.006.121

Abstract Image-based computational models for atherosclerotic plaques have been developed to perform mechanical analysis to quantify critical flow and stress/strain conditions related to plaque rupture which often leads directly to heart attack or stroke. An important modeling issue is how to determine zero stress state from in vivo plaque geometries. This paper presents a method to quantify human carotid artery axial and inner circumferential shrinkages by using patient-specific ex vivo and in vivo MRI images. A shrink-stretch process based on patient-specific in vivo plaque morphology and shrinkage data was introduced to shrink the in vivo geometry first to find the zero-stress… More >