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  • Open Access

    VIEWPOINT

    Crosslinking-mediated activation of the FcεRI: Does it need antigen for success?

    MICHAEL HUBER*, SANDRO CAPELLMANN

    BIOCELL, Vol.46, No.5, pp. 1125-1129, 2022, DOI:10.32604/biocell.2022.018513

    Abstract Mast cells (MCs), hematopoietic cells of the myeloid lineage, are well-known for their pro-inflammatory nature contributing to the development of various allergic and autoimmune diseases. One of the characteristic receptors on MCs, the high-affinity receptor for IgE (FcεRI), is activated in its IgE-bound state via binding and crosslinking by polyvalent antigen. This results in its phosphorylation by the SRC family kinase LYN, initiating differential signaling pathways, eventually triggering immunological effector functions, such as degranulation and cytokine production. Few publications have reported on FcεRI-dependent but antigen-independent MC activation by antibody-mediated crosslinking of membrane molecules (e.g., transmembrane proteins and glycosphingolipids) that are… More >

  • Open Access

    ARTICLE

    Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis

    XIAOYU WANG1,2,#,*, TAKESHI YAMAMOTO2,#, MAKOTO KADOWAKI2, YIFU YANG1

    BIOCELL, Vol.45, No.2, pp. 395-415, 2021, DOI:10.32604/biocell.2021.012280

    Abstract Mast cells are the main effector cells in IgE-associated allergic disorders, and we have reported that mucosal mast cells (MMCs) play a more important role in the development of food allergy (FA). IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway. The purpose of the present study was to identify gene signatures with IgE/antigen (dinitrophenyl-bovine serum albumin, DNP-BSA) or calcium ionophore (A23187) on the activation of MMCs. Differentially expressed genes between the two types of samples were identified with microarray analysis. Gene ontology functional and pathway enrichment analyses of differentially expressed… More >

  • Open Access

    REVIEW

    Review : Uterine mast cells: A new hypothesis to understand how we are born

    M. ISOLDE RUDOLPH1, I. GINA ROJAS2, ALICIA B. PENISSI3

    BIOCELL, Vol.28, No.1, pp. 1-11, 2004, DOI:10.32604/biocell.2004.28.001

    Abstract Birth is the result of complex, well-defined, and coordinated events, that are tightly regulated by endocrine, nervous, and immune responses, and take place primarily in the female reproductive tract. Various mechanisms and mediators involved in pregnancy, labor, and delivery, are highly conserved among different mammalian species and mast cells emerge as potential and crucial participants in these processes, as it is discussed in this review. More >

  • Open Access

    REVIEW

    Review : Role of mast cells in gastrointestinal mucosal defense

    Alicia B. Penissi*, María I. Rudolph**, Ramón S. Piezzi*

    BIOCELL, Vol.27, No.2, pp. 163-172, 2003, DOI:10.32604/biocell.2003.27.163

    Abstract The purpose of this review, based on studies from our laboratory as well as from others, is to summarize salient features of mast cell immunobiology and to describe their associations with gastrointestinal mucosal defense. Gastrointestinal mast cells are involved in many pathologic effects, such as food hypersensitivity. On the other hand, they also play a protective role in defense against parasitic and microbial infections. Thus, they have both positive and negative effects, but presently the mechanisms that control the balance of these various effects are poorly known. It has been suggested that stabilization of mast cells may be a key… More >

  • Open Access

    ARTICLE

    Estrogen receptors in mast cells from arterial walls

    S. NICOVANI , M.I. RUDOLPH

    BIOCELL, Vol.26, No.1, pp. 15-24, 2002, DOI:10.32604/biocell.2002.26.015

    Abstract We examined the presence of estrogen receptors (ER) in vascular mast cells and a possible genomic effect of estrogens on the expression of mast cell (MC) mediators such as chymase, TNFα, NOS and IL-10, which are known to affect the course of atherosclerosis. Immunocytochemical detection of mast cell tryptase and the co-localization of ERs in MCs from abdominal aortic vessels from 10 fertile woman, 10 postmenopausal women and 15 men was performed. The genomic expression of IL-10, TNFα, and NOS was analyzed by RT-PCR and chymase activity by spectrophotometry after 24 h incubation with 17-β estradiol (0.2-0.5 ng/mL) in rat… More >

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