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  • Open Access

    ARTICLE

    Bone Tissue Formation under Ideal Conditions in a Scaffold Generated by a Reaction-Diffusion System

    Marco A.Velasco, Diego A. Garzón-Alvarado

    Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 137-157, 2013, DOI:10.3970/mcb.2013.010.137

    Abstract The design of porous scaffolds for tissue engineering requires methods to generate geometries in order to control the stiffness and the permeability of the implant among others characteristics. This article studied the potential of the reaction-diffusion systems to design porous scaffolds for bone regeneration. We simulate the degradation of the scaffold material and the formation of new bone tissue over canal-like, spherical and ellipsoid structures obtained by this approach. The simulations show that the degradation and growth rates are affected by the form of porous structures. The results have indicated that the proposed method has More >

  • Open Access

    ARTICLE

    A New Mathematical Modeling of Maxwell Equations: Complex Linear Operator and Complex Field

    Chein-Shan Liu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.38, No.1, pp. 25-38, 2008, DOI:10.3970/cmes.2008.038.025

    Abstract In this paper a complex matrix operator and a complex field are used to express the Maxwell equations, of which the complex field embraces all field variables and the matrix operator embraces the time and space differential operators. By left applying the operator on the complex field one can get all the four Maxwell equations, which are usually expressed by the vector form. The new formulation matches the Lorenz gauge condition, and its mathematical advantage is that it can incorporate the Maxwell equations into a single equation. The introduction of four-potential is possible only under the More >

  • Open Access

    ARTICLE

    Optimization of Industrial Fluid Catalytic Cracking Unit having Five Lump Kinetic Scheme using Genetic Algorithm

    Shishir Sinha1, Praveen Ch.

    CMES-Computer Modeling in Engineering & Sciences, Vol.32, No.2, pp. 85-102, 2008, DOI:10.3970/cmes.2008.032.085

    Abstract Fluid catalytic cracking (FCC) unit plays most important role in the economy of a modern refinery that it is use for value addition to the refinery products. Because of the importance of FCC unit in refining, considerable effort has been done on the modeling of this unit for better understanding and improved productivity. The process is characterized by complex interactions among feed quality, catalyst properties, unit hardware parameters and process conditions. \newline The traditional and global approach of cracking kinetics is lumping. In the present paper, five lump kinetic scheme is considered, where gas oil… More >

  • Open Access

    ARTICLE

    Sensitivity of the Acoustic Scattering Problem in Prolate Spheroidal Geometry with Respect to Wavenumber and Shape

    D. Kourounis1, L.N. Gergidis1, A. Charalambopoulos1

    CMES-Computer Modeling in Engineering & Sciences, Vol.28, No.3, pp. 185-202, 2008, DOI:10.3970/cmes.2008.028.185

    Abstract The sensitivity of analytical solutions of the direct acoustic scattering problem in prolate spheroidal geometry on the wavenumber and shape, is extensively investigated in this work. Using the well known Vekua transformation and the complete set of radiating "outwards'' eigensolutions of the Helmholtz equation, introduced in our previous work ([Charalambopoulos and Dassios(2002)], [Gergidis, Kourounis, Mavratzas, and Charalambopoulos (2007)]), the scattered field is expanded in terms of it, detouring so the standard spheroidal wave functions along with their inherent numerical deficiencies. An approach is employed for the determination of the expansion coefficients, which is optimal in… More >

  • Open Access

    ARTICLE

    Acoustic Scattering in Prolate Spheroidal Geometry via Vekua Tranformation -- Theory and Numerical Results

    L.N. Gergidis, D. Kourounis, S. Mavratzas, A. Charalambopoulos1

    CMES-Computer Modeling in Engineering & Sciences, Vol.21, No.2, pp. 157-176, 2007, DOI:10.3970/cmes.2007.021.157

    Abstract A new complete set of scattering eigensolutions of Helmholtz equation in spheroidal geometry is constructed in this paper. It is based on the extension to exterior boundary value problems of the well known Vekua transformation pair, which connects the kernels of Laplace and Helmholtz operators. The derivation of this set is purely analytic. It avoids the implication of the spheroidal wave functions along with their accompanying numerical deficiencies. Using this novel set of eigensolutions, we solve the acoustic scattering problem from a soft acoustic spheroidal scatterer, by expanding the scattered field in terms of it. More >

  • Open Access

    ARTICLE

    Oxygen Transport in Tissue Engineering Systems: Cartilage and Myocardium

    B. Obradovic1, M. Radisic2, G. Vunjak-Novakovic3

    FDMP-Fluid Dynamics & Materials Processing, Vol.3, No.3, pp. 189-202, 2007, DOI:10.3970/fdmp.2007.003.189

    Abstract Efficient transport of oxygen is one of the main requirements in tissue engineering systems in order to avoid cell death in the inner tissue regions and support uniform tissue regeneration. In this paper, we review approaches to design of tissue engineering systems with adequate oxygen delivery for cultivation of cartilage and myocardium, two distinctly different tissue types with respect to the tissue structure and oxygen requirements. Mathematical modeling was used to support experimental results and predict oxygen transport within the cultivated tissues and correlate it to the cell response and tissue properties. More >

  • Open Access

    ARTICLE

    Water quality in the basin of the Amajac river, Hidalgo, Mexico: Diagnosis and prediction

    Amado Alvarez1,2, Enrique Rubiños Panta1, Francisco Gavi Reyes1, Juan José Alarcón Cabañero2, Elizabeth Hernández Acosta3, Carlos Ramírez Ayala1, Enrique Mejía Saenz1, Francisco Pedrero Salcedo2, Emilio Nicolas Nicolas2, Enrique Salazar Sosa4

    Phyton-International Journal of Experimental Botany, Vol.75, pp. 71-83, 2006, DOI:10.32604/phyton.2006.75.071

    Abstract A water quality index as a standardized method to compare the category in an integral way, between locations and through time, of the different water, river and stream storages of the Amajac river basin was developed. In addition, it is possible to predict the degree of contamination and establish planning strategies in the management of the water resources for the river basin in issue. The used methodology was based in the quantitative expression of water quality. Three samplings were made (2005-2006) and Dissolved Oxygen, Coliform in feaces, pH, Oxygen Biochemical Demand, Nitrates, Total Phosphorus, Turbidity… More >

  • Open Access

    ARTICLE

    A Mathematical Model of Cell Reorientation in Response to Substrate Stretching

    Konstantinos A. Lazopoulos1, Dimitrije Stamenović2

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 43-48, 2006, DOI:10.3970/mcb.2006.003.043

    Abstract It is well documented that in response to substrate stretching adhering cells alter their orientation. Generally, the cells reorient away from the direction of the maximum substrate strain, depending upon the magnitude of the substrate strain and the state of cell contractility. Theoretical models from the literature can describe only some aspects of this phenomenon. In the present study, we developed a more comprehensive mathematical model of cell reorientation than the current models. Using the framework of theory of non-linear elasticity, we found that the problem of cell reorientation was a stability problem, with the More >

  • Open Access

    ARTICLE

    An Improved Mathematical Approach for Determination of Molecular Kinetics in Living Cells with FRAP

    Tanmay Lele1,1, Philmo Oh1,1, Jeffrey A. Nickerson1,1,2,2, Donald E. Ingber1,1,3,3

    Molecular & Cellular Biomechanics, Vol.1, No.3, pp. 181-190, 2004, DOI:10.3970/mcb.2004.001.181

    Abstract The estimation of binding constants and diffusion coefficients of molecules that associate with insoluble molecular scaffolds inside living cells and nuclei has been facilitated by the use of Fluorescence Recovery after Photobleaching (FRAP) in conjunction with mathematical modeling. A critical feature unique to FRAP experiments that has been overlooked by past mathematical treatments is the existence of an `equilibrium constraint': local dynamic equilibrium is not disturbed because photobleaching does not functionally destroy molecules, and hence binding-unbinding proceeds at equilibrium rates. Here we describe an improved mathematical formulation under the equilibrium constraint which provides a more… More >

  • Open Access

    ARTICLE

    Computer Modeling and Simulation of Stationary-Vane, Rolling Piston Refrigeration Compressors

    G. Prater, Jr.1

    CMES-Computer Modeling in Engineering & Sciences, Vol.3, No.3, pp. 299-312, 2002, DOI:10.3970/cmes.2002.003.299

    Abstract A vapor compressor's performance is affected by pressure and mass flow fluctuations resulting from acoustic effects in the suction and discharge manifolds. Through proper geometric design of the manifolds, these pulsations can be modified to increase efficiency and reduce noise. This paper documents the development of a computer simulation program used to tune stationary-vane refrigeration compressors. The program models the mechanical, fluid, thermodynamic, kinematic, and acoustical processes occurring in such compressors, and calculates suction and discharge chamber pressures, mass flow rates, valve displacements, and acoustic input and transfer impedances. Experimental acoustic pressure measurements from a More >

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