A. Ferrari¹, L. Laloui^1,2, Ch. Bonnard^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.52, No.3, pp. 217-236, 2009, DOI:10.3970/cmes.2009.052.217

Abstract A coupled hydro-mechanical formulation is presented for the analysis of landslide motion during crisis episodes. The mathematical formulation is used to model a natural slope affected by a multiple slip surface failure mechanism, in which pore water pressure evolution was identified as the main cause for movement accelerations. An elasto-plastic constitutive model is adopted for the behaviour of slip surfaces. Material parameters are obtained by combining the available laboratory tests and the back analysis of some crisis episodes. After being calibrated and validated, the model is applied to improve the understanding of the physical processes More >

Sudib K. Mishra¹, J. K. Paik², S. N. Atluri¹

CMES-Computer Modeling in Engineering & Sciences, Vol.50, No.1, pp. 67-96, 2009, DOI:10.3970/cmes.2009.050.067

Abstract We present a simulation based study, by combining several models involving multiple time scales and physical processes, which govern the interfacial stress corrosion cracking (SCC) in grain boundaries, layered composites or bi-materials, and the mechanisms of inhibition using `smart' agents. The inhibiting agents described herein, automatically sense the initiation of damage, migrate to the sites and delay the corrosion kinetics involved in the process. The phenomenon of SCC is simulated using the lattice spring model (for the mechanical stresses), coupled with a finite difference model of diffusing species, causing the dissolution of the interfacial bonds.… More >

Marie-Caroline Le Bousse-Kerdilès^1,2, Marie-Claire Martyré^1,2, Michel Samson³

European Cytokine Network, Vol.19, No.2, pp. 69-80, 2008, DOI:10.1684/ecn.2008.0127

Abstract Chronic fibroproliferative diseases are an important cause of morbidity and mortality in the world. Fibrotic diseases occur in a large variety of vital organs, and the process of fibrosis seems common to all tissues. In all of fibrotic reactions, the underlying cellular and molecular mechanisms involve leukocyte infiltration, the persistence of inflammation in the tissue, and the proliferation of cells with a myofibroblast phenotype. The different cell types participating to this process sustain production of growth factors, proteolytic enzymes, angiogenic factors, and fibrogenic cytokines, which together stimulate the deposition of connective tissue elements that progressively More >

F. R. M. Romlay¹

Structural Durability & Health Monitoring, Vol.4, No.1, pp. 19-28, 2008, DOI:10.3970/sdhm.2008.004.019

Abstract This paper presents a surface contact static stress of a spur gear system combined with dynamic characteristic using transient Finite Element Method (FEM). Traditionally, the static stress analysis is done separately with dynamic properties due to limitation of complex equation and avoiding of error occurred. However, in this paper, static stress information is combined with the dynamic mechanism due to the time consuming during the design and analysis stage. A transient FEM analysis is carried out to formulate and solve large systems of algebraic equations in order to obtain a relationship between the contact parameter… More >

Romy P. Moreno¹, Mario G. Villeda², Sergio A. V. Pruneda², Zeferino D. Noriega², Pedro G. Segura²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.8, No.1, pp. 19-24, 2008, DOI:10.3970/icces.2008.008.019

Abstract Measuring the position, speed and acceleration of the moving elements of a mechanism usually involves external instrumentation that has to be attached to it, which is not always feasible. The method discussed here provides an alternative to measure these kinematics characteristics without modifying the components. To test the method in a controlled environment a four-bar mechanism was build. It was designed to be as thin as possible and to allow arbitrary changes in its lengths. Three commercial programs and a specially designed software (KIMA{\textregistered }) are used to record, analyze, measure, compute and verify the More >

Shaohua Chen^*

Molecular & Cellular Biomechanics, Vol.5, No.2, pp. 97-106, 2008, DOI:10.3970/mcb.2008.005.097

Abstract Recently, contact mechanics has been widely used to get some understanding of the biological adhesion mechanisms, such as cell-cell adhesion, insects' adhesion and locomotion. JKR theory is usually adopted as a basis, in which the interaction of molecules is considered in contrast to the classical Hertz solution. In this paper, two problems are summarized, which may give some insights to cells or bio-molecules sensitivity to environmental signals: (1) cell reorientation on a stretched substrate; (2) spontaneous detachment between cells or bio-molecules under the variation of environmental signals. The intention here is only to illustrate the… More >

Shuwang Li¹, Xiangrong Li¹, John Lowengrub^1,2, Martin Glicksman³

FDMP-Fluid Dynamics & Materials Processing, Vol.4, No.1, pp. 27-42, 2008, DOI:10.3970/fdmp.2008.004.027

Abstract In this paper, we suggest a deterministic mechanism for the generation and development of side-branches in dendritic growth. The present authors investigated recently [Glicksman, Lowengrub, and Li (2006)] the existence of such a deterministic branching mechanism induced through the Gibbs-Thomson-Herring (GTH [Herring (1951)]) anisotropic capillary boundary condition. In this paper, we focus our study on an anisotropic kinetic boundary condition. We develop and apply accurate boundary integral methods in 2D and 3D, in which a time and space rescaling scheme is implemented, that are capable of separating the dynamics of growth from those of morphology More >

Jacqueline Mohler¹, Pierre Moine¹, Esther Azoulay-Dupuis¹, Dominique Henin², Bruno Fantin¹

European Cytokine Network, Vol.18, No.1, pp. 23-30, 2007, DOI:10.1684/ecn.2007.0082

Abstract We used a Balb/c mouse model of pneumococcal pneumonia to investigate the protection mechanisms induced by immunization with a polyvalent 23 epitope polysaccharide pneumonia vaccine. Groups of mice were injected x 4 times s.c. within one month, with this vaccine preparation. Mice were subsequently challenged at day 45, with a lethal, intratracheal inoculum of two strains of Streptococcus pneumoniae – either a highly virulent and strongly immunogenic serotype 3 strain (P4241), or a less virulent and weakly immunogenic serotype 19F strain (P15986). The intratracheal S. pneumoniae challenge-induced lethality, antibody response, bacterial clearance, and cytokine secretions were monitored… More >

J. Mohler¹, P. Moine¹, E. Azoulay-Dupuis¹, D. Henin², B. Fantin¹

European Cytokine Network, Vol.18, No.1, pp. 18-25, 2007, DOI:10.1684/ecn.2007.0082

Abstract We used a Balb/c mouse model of pneumococcal pneumonia to investigate the protection mechanisms induced by immunization with a polyvalent 23 epitope polysaccharide pneumonia vaccine. Groups of mice were injected x 4 times s.c. within one month, with this vaccine preparation. Mice were subsequently challenged at day 45, with a lethal, intratracheal inoculum of two strains of Streptococcus pneumoniae – either a highly virulent and strongly immunogenic serotype 3 strain (P4241), or a less virulent and weakly immunogenic serotype 19F strain (P15986). The intratracheal S. pneumoniae challenge-induced lethality, antibody response, bacterial clearance, and cytokine secretions were monitored… More >

J. Mohler¹, P. Moine¹, E. Azoulay-Dupuis¹, D. Henin², B. Fantin¹

European Cytokine Network, Vol.18, No.1, pp. 1-8, 2007, DOI:10.1684/ecn.2007.0082

Abstract We used a Balb/c mouse model of pneumococcal pneumonia to investigate the protection mechanisms induced by immunization with a polyvalent 23 epitope polysaccharide pneumonia vaccine. Groups of mice were injected x 4 times s.c. within one month, with this vaccine preparation. Mice were subsequently challenged at day 45, with a lethal, intratracheal inoculum of two strains of Streptococcus pneumoniae – either a highly virulent and strongly immunogenic serotype 3 strain (P4241), or a less virulent and weakly immunogenic serotype 19F strain (P15986). The intratracheal S. pneumoniae challenge-induced lethality, antibody response, bacterial clearance, and cytokine secretions were monitored… More >