Kristina A. Kritskaya, Evgeniya I. Fedotova, Alexander D. Nadeev^*, Alexey V. Berezhnov^*

BIOCELL, Vol.49, No.3, pp. 451-464, 2025, DOI:10.32604/biocell.2025.061624 - 31 March 2025

Abstract Objective: Activation of mitophagy is a promising option to overcome the mitochondrial malfunction that accompanies many diseases. Herein, we investigate the mechanisms underlying the ability of sodium lactate and pyruvate to initiate mitophagy, from the perspective of action on mitochondrial network and expression levels. Methods: Fluorescent and confocal microscopy was used to assess key cell parameters characterizing the state of the mitochondrial network and the level of mitophagy in human fibroblasts carrying mutations in genes encoding LRRK2 and PINK1 after the combined application of lactate and pyruvate and after direct acidification. qRT-PCR was used to… More >

Juan Yang^1,2,#, Jiahui Zhang^3,#, Le Zhang^1,2,*, Zhenshan Yang^4,*

BIOCELL, Vol.49, No.3, pp. 399-417, 2025, DOI:10.32604/biocell.2025.059908 - 31 March 2025

Abstract With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to More >

Yi-Ze Wu, Yi-Cheng Huang^*

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 97-114, 2025, DOI:10.32604/cmc.2025.063441 - 26 March 2025

Abstract Precision steel balls are critical components in precision bearings. Surface defects on the steel balls will significantly reduce their useful life and cause linear or rotational transmission errors. Human visual inspection of precision steel balls demands significant labor work. Besides, human inspection cannot maintain consistent quality assurance. To address these limitations and reduce inspection time, a convolutional neural network (CNN) based optical inspection system has been developed that automatically detects steel ball defects using a novel designated vertical mechanism. During image detection processing, two key challenges were addressed and resolved. They are the reflection caused… More >

Nizar Zaghden¹, Emad Ibrahim², Mukaram Safaldin^2,*, Mahmoud Mejdoub³

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1117-1147, 2025, DOI:10.32604/cmc.2025.061948 - 26 March 2025

Abstract The increasing elderly population has heightened the need for accurate and reliable fall detection systems, as falls can lead to severe health complications. Existing systems often suffer from high false positive and false negative rates due to insufficient training data and suboptimal detection techniques. This study introduces an advanced fall detection model integrating YOLOv8, Faster R-CNN, and Generative Adversarial Networks (GANs) to enhance accuracy and robustness. A modified YOLOv8 architecture serves as the core, utilizing spatial attention mechanisms to improve critical image regions’ detection. Faster R-CNN is employed for fine-grained human posture analysis, while GANs… More >

Tariq Mahmood^1,2, Tanzila Saba¹, Faten S. Alamri^3,*, Alishba Tahir⁴, Noor Ayesha⁵

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1173-1193, 2025, DOI:10.32604/cmc.2025.061150 - 26 March 2025

Abstract Innovation in learning algorithms has made retinal vessel segmentation and automatic grading techniques crucial for clinical diagnosis and prevention of diabetic retinopathy. The traditional methods struggle with accuracy and reliability due to multi-scale variations in retinal blood vessels and the complex pathological relationship in fundus images associated with diabetic retinopathy. While the single-modal diabetic retinopathy grading network addresses class imbalance challenges and lesion representation in fundus image data, dual-modal diabetic retinopathy grading methods offer superior performance. However, the scarcity of dual-modal data and the lack of effective feature fusion methods limit their potential due to… More >

Xiao Feng^1,2,3,*, Xiao Liao^1,3, Xiaokang Lin^1,3, Yonggui Wang^1,3

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1307-1325, 2025, DOI:10.32604/cmc.2025.061069 - 26 March 2025

Abstract In the context of the diversity of smart terminals, the unity of the root of trust becomes complicated, which not only affects the efficiency of trust propagation, but also poses a challenge to the security of the whole system. In particular, the solidification of the root of trust in non-volatile memory (NVM) restricts the system’s dynamic updating capability, which is an obvious disadvantage in a rapidly changing security environment. To address this issue, this study proposes a novel approach to generate root security parameters using static random access memory (SRAM) physical unclonable functions (PUFs). SRAM… More >

Jia Liu¹, Hang Gu¹, Fangmei Liu¹, Hao Chen¹, Zuhe Li¹, Gang Xu², Qidong Liu², Wei Wang^2,*

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 803-822, 2025, DOI:10.32604/cmc.2025.060966 - 26 March 2025

Abstract In recent years, convolutional neural networks (CNN) and Transformer architectures have made significant progress in the field of remote sensing (RS) change detection (CD). Most of the existing methods directly stack multiple layers of Transformer blocks, which achieves considerable improvement in capturing variations, but at a rather high computational cost. We propose a channel-Efficient Change Detection Network (CE-CDNet) to address the problems of high computational cost and imbalanced detection accuracy in remote sensing building change detection. The adaptive multi-scale feature fusion module (CAMSF) and lightweight Transformer decoder (LTD) are introduced to improve the change detection More >

Jeng-Shyang Pan^1,2,3, Mengfei Zhang¹, Shu-Chuan Chu^2,*, Xingsi Xue⁴, Václav Snášel⁵

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 475-496, 2025, DOI:10.32604/cmc.2025.060170 - 26 March 2025

Abstract Data clustering is an essential technique for analyzing complex datasets and continues to be a central research topic in data analysis. Traditional clustering algorithms, such as K-means, are widely used due to their simplicity and efficiency. This paper proposes a novel Spiral Mechanism-Optimized Phasmatodea Population Evolution Algorithm (SPPE) to improve clustering performance. The SPPE algorithm introduces several enhancements to the standard Phasmatodea Population Evolution (PPE) algorithm. Firstly, a Variable Neighborhood Search (VNS) factor is incorporated to strengthen the local search capability and foster population diversity. Secondly, a position update model, incorporating a spiral mechanism, is… More >

Jianfeng Lu¹, Tao Huang¹, Yuanai Xie^2,*, Shuqin Cao¹, Bing Li³

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 619-634, 2025, DOI:10.32604/cmc.2025.060094 - 26 March 2025

Abstract The proliferation of deep learning (DL) has amplified the demand for processing large and complex datasets for tasks such as modeling, classification, and identification. However, traditional DL methods compromise client privacy by collecting sensitive data, underscoring the necessity for privacy-preserving solutions like Federated Learning (FL). FL effectively addresses escalating privacy concerns by facilitating collaborative model training without necessitating the sharing of raw data. Given that FL clients autonomously manage training data, encouraging client engagement is pivotal for successful model training. To overcome challenges like unreliable communication and budget constraints, we present ENTIRE, a contract-based dynamic… More >

Zhiyong Li, Xinlian Zhou^*

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 739-760, 2025, DOI:10.32604/cmc.2025.059807 - 26 March 2025

Abstract Brain tumor classification is crucial for personalized treatment planning. Although deep learning-based Artificial Intelligence (AI) models can automatically analyze tumor images, fine details of small tumor regions may be overlooked during global feature extraction. Therefore, we propose a brain tumor Magnetic Resonance Imaging (MRI) classification model based on a global-local parallel dual-branch structure. The global branch employs ResNet50 with a Multi-Head Self-Attention (MHSA) to capture global contextual information from whole brain images, while the local branch utilizes VGG16 to extract fine-grained features from segmented brain tumor regions. The features from both branches are processed through More >